Computed Tomographic Findings and Prognosis in Thymic Epithelial Tumor Patients

Yakushiji, Satomi; Tateishi, Ukihide; Nagai, Shunji; Matsuno, Yoshihiro; Nakagawa, Kazuo; Asamura, Hisao; Kusumoto, Masahiko

doi:10.1097/rct.0b013e31815896df

Cited by 22 publications

(16 citation statements)

References 22 publications

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“…Many studies have reported that TETs have characteristic computed tomography (CT) findings (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). To our knowledge, however, there has been few reports (17,19) assessing the relationship between tumor volume (TV) on CT and each subtype.…”

Section: Original Articlementioning

confidence: 99%

Volumetric analysis of the thymic epithelial tumors: correlation of tumor volume with the WHO classification and Masaoka staging

et al. 2018

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Background: The purpose of our study was to investigate the correlation between tumor volume (TV) and each subtype of thymic epithelial tumors (TETs) based on the World Health Organization (WHO) classification and Masaoka staging. Methods: Sixty-one consecutive patients (45 thymomas and 16 thymic carcinomas) were studied. All were classified according to Masaoka staging: 31 non-invasive TETs (stage I) and 30 invasive TETs (8 stage II, 11 stage III, 3 stage IVa, and 8 stage IVb). TV on computed tomography (CT) were semi-automatically calculated using our software. The correlation of TV with each WHO subtype and Masaoka staging was analyzed using Mann-Whitney U and Scheffe's F test. Results: Thymic carcinoma (mean ± SD, 117.5±143.6 cm 3) was significantly larger than thymoma (53.4±78.4 cm 3) (P=0.0016). Stage IVb tumor (190.8±156.8 cm 3) was significantly larger than stage I (33.1±42.6 cm 3) (P<0.05). Invasive TETs were significantly larger than non-invasive TETs (P=0.0016). TV >54.3 cm 3 indicated invasive TETs. Conclusions: TV of invasive TETs may be larger at the time of initial presentation. TV >54.3 cm 3 indicates invasive TETs.

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Section: Original Articlementioning

confidence: 99%

Volumetric analysis of the thymic epithelial tumors: correlation of tumor volume with the WHO classification and Masaoka staging

et al. 2018

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“…but it cannot accurately differentiate between different subtypes of WHO classifications (11)(12)(13)(14)(15)(16)(17)(18). The importance of CT findings to distinguish early and late clinical stages has already been described (1)(2)(3)(4)16).…”

Section: Thoracic Imaging: Diffusion-weighted Mr Imaging In Thymic Epmentioning

confidence: 99%

Diffusion-weighted MR Imaging in Thymic Epithelial Tumors: Correlation with World Health Organization Classification and Clinical Staging

Razek¹,

Khairy²,

Nada³

2014

Radiology

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“…CT has been thought to have a limited role in the detection of tumor invasiveness (36), even though there have been very few systematic studies comparing CT findings and thymoma invasiveness. The majority of studies assessing the thymus have included either thymic hyperplasia or thymic carcinoma, have not provided statistical analysis of the thymoma patient group alone, and have usually described these tumors with reference to the WHO classification system rather than the clinically used Masaoka-Koga staging system (37)(38)(39)(40)(41)(42). However, three new studies have compared Masaoka-Koga stage with CT findings.…”

Section: Imaging Evaluationmentioning

confidence: 99%

Role of Imaging in the Diagnosis, Staging, and Treatment of Thymoma

Benveniste¹,

Rosado-de-Christenson²,

Sabloff³

et al. 2011

RadioGraphics

125

129

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Thymoma is a rare mediastinal neoplasm but is the most common primary neoplasm of the anterior mediastinum. There have been only a few published reports assessing this disease. Furthermore, many of these reports are from a single institution and span several decades, which may lead to potentially misleading conclusions related to diagnosis, staging, and treatment. Computed tomography is the imaging modality of choice for evaluating thymoma and can help distinguish thymoma from other anterior mediastinal abnormalities. Tumor stage and extent of resection are the most important prognostic factors. Tumors that are encapsulated and are amenable to complete resection have a good prognosis, whereas invasive and unresectable tumors have a poor prognosis regardless of their histologic characteristics. Radiologists must be aware of the full spectrum of imaging findings of thymoma, the standard guidelines for diagnostic evaluation, and how imaging findings affect therapeutic decisions.

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Computed Tomographic Findings and Prognosis in Thymic Epithelial Tumor Patients

Abstract: Vascular obliteration and a blunt sternum-anterior mediastinum angle were predictive of thymic carcinoma. Pleural effusion and mediastinal fat infiltration were predictive of a poor prognosis.

Cited by 22 publications

References 22 publications

Volumetric analysis of the thymic epithelial tumors: correlation of tumor volume with the WHO classification and Masaoka staging

Volumetric analysis of the thymic epithelial tumors: correlation of tumor volume with the WHO classification and Masaoka staging

Diffusion-weighted MR Imaging in Thymic Epithelial Tumors: Correlation with World Health Organization Classification and Clinical Staging

Role of Imaging in the Diagnosis, Staging, and Treatment of Thymoma

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