Computed tomographic findings in 12 cases of canine multi‐centric lymphoma with splenic and hepatic involvement

Jones, Ian D.; Daniëls, Annick; Lara-García, Ana; Peters, Laureen M.; Mantis, Panagiotis

doi:10.1111/jsap.12714

Cited by 8 publications

(21 citation statements)

References 18 publications

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“…Cytological or histopathological evaluation of specific sites can be necessary for a definitive organ involvement confirmation 18. Full‐body CT scan has some limitations in the staging of multicentric lymphomas compared with thoracic radiographs and abdominal ultrasound with cytology of the liver and spleen 19. Unfortunately, liver and spleen cytology and bone marrow cytology and biopsy were not acquired in this case prior to treatment or at ‘relapse’; therefore, infiltration of these organs could not be completely ruled out.…”

Section: Discussionmentioning

confidence: 94%

Mediastinal T‐cell lymphoma with presumed secondary monostotic long bone involvement in the absence of local recurrence

Mosca

Greville-Heygate

Constantino‐Casas

et al. 2020

Vet Record Case Reports

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A 7-year-old male neutered cocker crossbreed was presented with a 1-month history of tachypnoea and exercise intolerance. Initial investigations confirmed a pleural effusion due to a mediastinal T-cell lymphoma. L-asparaginase and a 23-week lomustine, vincristine, prednisolone protocol were pursued and complete response was recorded at the end of the protocol. Ten months later, he was presented at the referring veterinary practice with a non-bearing lameness of his left forelimb, and a transcondylar screw was placed following the suspicion of a fracture of the lateral humeral epicondyle. During surgery, a sample of bone was collected and submitted for histopathology. Histopathology and immunohistochemistry were consistent with a T-cell lymphoma. Total body CT scan revealed a monostotic aggressive lesion of the distal humerus with no evidence of infiltration into bone at any other sites, and no other signs of lymphoma relapse were seen elsewhere in the body. Based on these findings, secondary bone lymphoma was hypothesised.

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Section: Discussionmentioning

confidence: 94%

Mediastinal T‐cell lymphoma with presumed secondary monostotic long bone involvement in the absence of local recurrence

Mosca

Greville-Heygate

Constantino‐Casas

et al. 2020

Vet Record Case Reports

View full text Add to dashboard Cite

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“…The observers evaluated the US images and subsequently the corresponding written report to ensure that the recorded images were a true and comprehensive representation of the reported findings. Observations about each case were recorded directly into a spreadsheet that prompted entries for a range of CT and US imaging features formulated and agreed by the authors in advance based on review of the reference literature 8,11 . Observers had to reach agreement about the description of the findings present and classification of each imaging study as normal or abnormal.…”

Section: Methodsmentioning

confidence: 99%

“…Advanced diagnostic imaging modalities are becoming more readily available, and Computed tomography (CT) is now commonly used in veterinary medicine. However, in a recent study, the CT appearance of the liver and spleen in dogs with lymphoma was normal in the majority of the cases 11 . Therefore, when using US to stage dogs with lymphoma it has been recommended in one study to perform fine needle aspiration of the spleen only if the organ appears abnormal and of the liver regardless of its appearance 9 .…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, when using US to stage dogs with lymphoma it has been recommended in one study to perform fine needle aspiration of the spleen only if the organ appears abnormal and of the liver regardless of its appearance 9 . Whereas if CT is used both organs should be sampled independently of their appearnce 11 . Regardless of the diagnostic imaging protocol chosen for staging, samples of the liver and spleen are usually performed with US guidance.…”

Section: Introductionmentioning

confidence: 99%

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Comparison between computed tomographic and ultrasonographic findings of the liver and spleen in dogs with confirmed hepatic or splenic lymphoma involvement

et al. 2021

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Background Computed tomography (CT) and ultrasonography (US) may be used to assist staging in dogs with lymphoma. The imaging features of splenic and hepatic infiltration have never been directly compared in the same population of dogs. Methods The aim of this retrospective study was to describe and compare the CT and US findings of the liver and spleen in dogs with confirmed hepatic and/or splenic lymphoma and compare imaging and cytological diagnoses. Results CT and US studies of 18 dogs with multicentric lymphoma involving the liver and/or the spleen were retrospectively evaluated. US detected abnormalities more frequently than CT in the spleen with lymphoma, whereas CT detected abnormalities more frequently in the liver with lymphoma. The two diagnostic imaging modalities often disagreed in the findings, including the imaging classification of the organ as normal or abnormal. Conclusion US and CT often disagree in the imaging findings present in hepatic and splenic lymphoma. The results of this study suggest that cytologic evaluation of both the liver and spleen is advisable regardless of their US or CT appearance for detection of lymphoma.

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“…Ultrasound-guided fine-needle sample collection for cytology is used as a primary assessment of liver disease in human and veterinary patients because of its simplicity, speed, and low risk for complications [13][14][15][16] and remains the most commonly used staging technique for metastatic lymphoma [17]. Aspiration of the liver is recommended for the detection of lymphoma r egardless of its ultrasonographic appearance [18]. The fine-needle non-aspiration technique was found to be superior to the aspiration technique [19,20].…”

Section: Introductionmentioning

confidence: 99%

Comparison of fine-needle cytologic diagnosis between the left and right liver lobes of dogs and cats with diffuse liver disease

et al. 2021

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Background and Aim: Ultrasound-guided fine-needle sample collection for cytology with manual restraint is frequently used for the primary assessment of diffuse liver disease in veterinary patients in Thailand. For better diagnosis, repeated collection of samples ensures the collection of adequate, representative samples, which increase diagnostic accuracy. However, in those that are unable to receive general anesthesia, it is difficult to collect the samples from several liver locations in manually restrained dogs and cats. The study aimed to compare the cytologic diagnosis of the ultrasound-guided fine-needle non-aspiration technique between the left and right liver lobes in dogs and cats with neoplastic and non-neoplastic diffuse liver disease. Materials and Methods: This prospective study included 25 client-owned dogs and cats with diffuse liver diseases. Two liver samples were randomly collected from the left and right liver lobes under ultrasound guidance for cytologic examination. All slides were subsequently examined blindly by experienced pathologists for cytologic analysis with cytologic agreement scores (CASs). Results: Among all 50 samples obtained from ultrasound-guided fine-needle sample collection of the left and right liver, 78% were diagnostic and 22% were non-diagnostic. In the diagnostic group, 73.3% of fine-needle samples had concordant results between the left and right liver, which exhibited 100% cytologic agreement in lymphoma and 63.6% in non-neoplastic groups. Samples collected from the left liver had slightly higher CAS and higher cytologic quality than had those from the right liver lobe (p=0.053). Conclusion: The location and number of sample collections did not have a significant difference in the cytologic diagnosis of diffuse liver disease, especially in patients with lymphoma. For manually restrained patients, one time ultrasound-guided non-aspiration cytology procedure from the left liver lobe not only decreased restraint duration and minimized tissue trauma but also allowed for an adequate cytologic diagnosis in diffuse liver disease compared to multiple collections.

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Computed tomographic findings in 12 cases of canine multi‐centric lymphoma with splenic and hepatic involvement

Abstract: The CT appearance of the spleen and liver was normal in the majority of dogs with multi-centric lymphoma. Fine needle aspiration of the spleen and liver is recommended when using CT to stage dogs with multi-centric lymphoma.

Cited by 8 publications

References 18 publications

Mediastinal T‐cell lymphoma with presumed secondary monostotic long bone involvement in the absence of local recurrence

Mediastinal T‐cell lymphoma with presumed secondary monostotic long bone involvement in the absence of local recurrence

Comparison between computed tomographic and ultrasonographic findings of the liver and spleen in dogs with confirmed hepatic or splenic lymphoma involvement

Comparison of fine-needle cytologic diagnosis between the left and right liver lobes of dogs and cats with diffuse liver disease

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