Computed Tomographic Patterns of Muscles in Neuromuscular Diseases

Hawley, Rollin J.; Schellinger, Dieter; O'Doherty, Desmond S.

doi:10.1001/archneur.1984.04050160045014

Cited by 81 publications

(35 citation statements)

References 4 publications

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“…However, CT number do not usually decrease [3,4]. A decrease in the CT number is preceded by a reduction of cross-sectional area, and the CT number decreases in the final stage of disease [3,4]. In this study, both the crosssectional areas and CT number decreased, although the results differed somewhat from those reported in humans.…”

contrasting

confidence: 53%

“…In addition to electromyography and muscle biopsy, Xray computed tomography (CT) is often used to diagnose muscle disease in humans [1,2,3,5,7] because morphological changes can be observed noninvasively even in deep muscles [4,7,9,10]. However, CT has not been used to diagnose muscle disease in veterinary medicine.…”

mentioning

confidence: 99%

“…In humans, atrophy appears in the CT image as a markedly reduced muscle cross-sectional area after denervation. However, CT number do not usually decrease [3,4]. A decrease in the CT number is preceded by a reduction of cross-sectional area, and the CT number decreases in the final stage of disease [3,4].…”

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confidence: 99%

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Computed Tomographic Findings of Experimentally Induced Neurogenic Muscular Atrophy in Dogs.

Orima

Fujita

1997

The Journal of Veterinary Medical Science

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ABSTRACT. Neurogenic muscular atrophy was examined using computed tomography (CT) in dogs induced by crushing the sciatic nerve. The CT number and cross-sectional area in denervated muscles decreased in 1 to 2 weeks after denervation. Those were significant after 3 weeks. The examination with CT might be useful to diagnose canine neurogenic muscular atrophy. -KEY WORDS: canine, CT, muscle atrophy.J. Vet. Med. Sci. 59(8): 729-731, 1997 window level and width were set at 50 HU and 250 HU respectively. CT images were also evaluated under the other conditions in necessary. We observed well-defined biceps, semimembranosus, and semitendinosus, in comparison with the quadriceps innervated by the femoral nerve and the adductor innervated by the obturator nerve as controls. CT numbers were measured at three arbitrarily chosen regions for each muscle, and the mean values were regarded as the CT number for that muscle. The cross-sectional area of each muscle was measured, using an area-measurement program of CT unit by manually tracing the muscle margin on the CT image. The crosssectional area of the femoral bone was measured likewise, and the cross-sectional area of a muscle was expressed as its ratio to the cross-sectional area of the femoral bone.On day 28, the semitendinosus muscle in one dog was taken from a region which would not influence subsequent CT examination. The sample was examined histopathologically.All procedures were conducted according to the Guidelines for the Care and Use of Laboratory Animals of The Nippon Veterinary and Animal Science University. Within eight months after the end of the experiment, the dogs showed no neurologic abnormality in the affected leg.CT images showed decreases in CT number and muscle cross-sectional areas (Fig. l). Before denervation CT numbers (HU) of muscles were 58.4 ± 2.2 for the biceps, 56.0 ± 1.8 for the semimembranosus, 50.0 ± 3.2 for the semitendinosus, 57.8 ± 3.7 for the quadriceps, and 58.7 ± 2.1 for the adductor. The semitendinosus was difficult to be measured accurately because of its small cross-sectional area. In the three muscles innervated by the sciatic nerve CT numbers increased on day 1, and then tended to decrease from day 14 after surgery, continuing to decrease relatively rapidly until day 28. A slight further decrease was observed thereafter with minimum values on day 56 (Fig. 2).The cross-sectional areas of the muscles were measured on the CT images before denervation. The ratios to the cross-sectional area of the femoral bone were 6.8 ± 1.6 for the biceps, 5.5 ± 1.8 for the semimembranosus, 2.7 ± 1.6 for the semitendinosus, 6.2 ± 1.7 for the quadriceps, and 11.2 ± 3

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Computed Tomographic Findings of Experimentally Induced Neurogenic Muscular Atrophy in Dogs.

Orima

Fujita

1997

The Journal of Veterinary Medical Science

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“…Computed tomography (CT) of lower limb muscles was performed bilaterally in the mid-sections of the thigh and lower leg at computer tomographic scanner (Siemens, Somaton, Germany) with axial 5mm thick slices. Abnormal signal was classified according to Hawley et al [18]. Magnetic resonance imaging (MRI) of 20 muscles bilaterally was performed at a 1.5-tesla Siemens; Magneton Vision system using axial T1 weighted (T1W) images.…”

Section: Methodsmentioning

confidence: 99%

“…It is unclear when biceps brachii muscles are involved in patient with SPD: is it before or after an affection of the lower limb muscles? In the recent years, several studies have reported the value of CT and MRI in identifying patterns of muscle involvement in FSHD [18][19][20][21]. However, it is not clear as what are the CT and MRI findings for lower limb muscles are present in facioscapuloperoneal muscular dystrophy (FSPMD) patients.…”

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confidence: 99%

The Autosomal Dominant Facioscapuloperoneal Muscular Dystrophy with 4q35 Chromosomal Deletion in Two Russian Families

Kazakov¹

2013

Hereditary Genetics

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We give the description of the pattern of muscle affections in two autosomal dominant 4q35-linked facioscapuloperoneal muscular dystrophy (FSPMD) families in which the patients were re-examined by V.K. in 24 -28 and 35 -37 years after their first examination. The disease started with initial involvement of facial and shoulder girdle muscles and in some time later of the peroneal group (anterior tibial) of muscles became involved. However, in two probands the dystrophic process gradually extended to the thighs (posterior group of muscles, namely), pelvic girdle (gluteus maximus muscles, namely) and the upper arm (biceps brachii muscles were slightly affected) and in three their relatives with clinical facioscapuloperoneal (FSP) phenotype the severe involvement of some posterior thigh muscles during MRI study was revealed. In this connection, the term "facioscapulolimb muscular dystrophy, type 2 (FSLD2), a descending type with a "jump" with initial FSP phenotype" would be more correct instead of the name facioscapuloperoneal muscular dystrophy. The FSP phenotype constitutes merely a stage in the development of FSLD2. The CT and MRI pattern of muscle involvement does not fully correlate with clinical pattern of muscle affection. We suppose that classical AD FSPMD is an independent clinical form which is different from the classical FSHD although both of them are connected with 4q35 chromosomal deletion.

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