Computed Tomographic Perfusion Imaging for the Therapeutic Response of Chemoembolization for Hepatocellular Carcinoma

Yang, Lin; Zhang, Xiaoming; Tan, Bang-xian; Liu, Mi; Guo-li, Dong; Zhai, Zhao-Hua

doi:10.1097/rct.0b013e318245c23c

Cited by 35 publications

(14 citation statements)

References 15 publications

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“…It mostly occurs in patients with chronic hepatitis and cirrhosis. The outcome of patients with untreated HCC is very poor (3). One of the important features in staging is tumor vascularity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hepatocellular carcinoma with computed tomography perfusion imaging

Bayraktutan¹,

Kantarcı²,

Oğul³

et al. 2014

Turk J Med Sci

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The productivity of winter oilseed rape cultivars is limited by various pests and diseases. The aim of this study was to determine the differences in the susceptibility of Lithuanian-grown winter rape cultivars to main fungal diseases, their yield performance, and their response to the fungicide application. A 2-factorial field experiment was carried out at the Institute of Agriculture of the Lithuanian Research Centre for Agriculture and Forestry over 3 growing seasons (2007/08, 2008/09, and 2009/10). The influence of fungicide application and cultivar (15 cultivars during the first and second seasons, and 6 cultivars during the third season) on the incidence and severity of phoma stem canker, alternaria black spot, and sclerotinia stem rot, as well as on the seed yield and thousand-seed weight, was evaluated. Experimental findings indicated that the incidence and severity of fungal diseases varied considerably among the growing seasons. The incidence of basal phoma stem canker was significantly influenced by the cultivar during all 3 growing seasons; however, significant effect of the cultivar on the mean severity of basal canker was obtained only in 2009. Fungicide spray applications significantly decreased the incidence and severity of fungal diseases and significantly increased the seed yield of winter rape. Significant and positive yield response to the fungicide application was obtained for almost all tested cultivars during the first 2 seasons. Cultivars that were higher yielding without treatment (Insider, Sunday, Monalisa, Rally, and Titan) showed lower response to the fungicide application. The use of fungicides demonstrated the highest economic return from the cultivars Lirajet, Casino, Siska, Liprima, and Valesca.

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Section: Discussionmentioning

confidence: 99%

Evaluation of hepatocellular carcinoma with computed tomography perfusion imaging

Bayraktutan¹,

Kantarcı²,

Oğul³

et al. 2014

Turk J Med Sci

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“…The accurate evaluation of TACE treatment response is conducive to the next step of developing personalized treatment programs. However, assessment of anatomic response in the early post-treatment period has been controversial because the absence of a reduction in tumor size does not mean an absence of response [6] [7] [8]. Magnetic resonance diffusion weighted imaging (DWI) can detect the free diffusion motion of water molecules in living tissue.…”

Section: Introductionmentioning

confidence: 99%

Intravoxel Incoherent Motion Diffusion Weighted Imaging for the Therapeutic Response of Transarterial Chemoembolization for Hepatocellular Carcinoma

Peng¹,

Yang²,

Zheng³

et al. 2019

JCT

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Background: Intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) can not only observe the diffusion of tissue water molecules but also reflect the blood perfusion information of tissue microcirculation. IVIM-DWI has been applied in many clinical areas. However, few studies have addressed the use of IVIM-DWI for the evaluation of transarterial chemoembolization (TACE) response in hepatocellular carcinoma (HCC) patients. Objectives: The purpose of the present study was to explore the role of IVIM-DWI for the therapeutic response of TACE for HCC. Materials and Methods: Twenty patients underwent IVIM-DWI scan on a 3.0T magnetic resonance imaging instrument 1-3 days before and 30 to 40 days after TACE. The values of IVIM-DWI parameters, including standard apparent diffusion coefficient (ADC), pure diffusion coefficient (Dslow), pseudo-diffusion coefficient (Dfast) and perfusion fraction (ƒ) were measured. The values of IVIM-DWI parameters before and after TACE were compared using paired t tests. The values between responsive and non-responsive groups were compared using independent-samples t test. P < 0.05 indicated statistical significance. Results: After TACE, the ADC and Dslow values in the tumors increased significantly, and the values of Dfast decreased significantly, while the values of f value did not change obviously. The ADC values in responsive group were remarkably higher than those in non-responsive group, the Dfast values in responsive group were significantly lower than those in non-responsive group, but the values of Dslow and f between the two groups were not different significantly.

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“…Yang et al . [ 56 ] reported that the values of hepatic arterial perfusion, total liver perfusion, and hepatic arterial perfusion index in tumors significantly decreased 4 weeks after TACE in comparison to those before TACE. Previous studies reported reduction in BF or BV after 10-12 days of antiangiogenic therapy without any significant change in tumor size based on RECIST [ Figure 5 ].…”

Section: Introductionmentioning

confidence: 99%

Imaging for assessment of treatment response in hepatocellular carcinoma: Current update

Hayano

Lee

Sahani

2015

Indian Journal of Radiology and Imaging

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Morphologic methods such as the Response Evaluation Criteria in Solid Tumors (RECIST) are considered as the gold standard for response assessment in the management of cancer. However, with the increasing clinical use of antineoplastic cytostatic agents and locoregional interventional therapies in hepatocellular carcinoma (HCC), conventional morphologic methods are confronting limitations in response assessment. Thus, there is an increasing interest in new imaging methods for response assessment, which can evaluate tumor biology such as vascular physiology, fibrosis, necrosis, and metabolism. In this review, we discuss various novel imaging methods for response assessment and compare them with the conventional ones in HCC.

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Computed Tomographic Perfusion Imaging for the Therapeutic Response of Chemoembolization for Hepatocellular Carcinoma

Abstract: Computed tomographic perfusion imaging has the ability to evaluate the perfusion changes in HCC after chemoembolization, which can be used to evaluate the therapeutic response of chemoembolization for hepatocellular carcinoma.

Cited by 35 publications

References 15 publications

Evaluation of hepatocellular carcinoma with computed tomography perfusion imaging

Evaluation of hepatocellular carcinoma with computed tomography perfusion imaging

Intravoxel Incoherent Motion Diffusion Weighted Imaging for the Therapeutic Response of Transarterial Chemoembolization for Hepatocellular Carcinoma

Imaging for assessment of treatment response in hepatocellular carcinoma: Current update

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