Computed Tomographic Scan Hemispheric Asymmetries in Right- and Left-handed Male and Female Subjects

Koff, Elissa; Naeser, Margaret A.; Pieniadz, Jean; Foundas, Anne L.; Levine, Harvey L.

doi:10.1001/archneur.1986.00520050059023

Cited by 84 publications

(26 citation statements)

References 22 publications

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“…A similar effect can be also seen in the 152-subject averaged anatomical image provided as a sample image with the FSL software package. These observations also agree with previous morphological studies (Charles et al, 1994;Kertesz et al, 1986;Koff et al, 1986;Lemay, 1977). …”

Section: Resultssupporting

confidence: 93%

“…The results obtained in this study suggest that the low statistical significance of signals in the right side of the visual cortex are at least partly due to the larger distance between this part of the brain and the surface of the head. Previous morphological studies have found the left occipital lobe to be wider and longer than the right lobe (Charles et al, 1994;Kertesz et al, 1986;Koff et al, 1986;Lemay, 1977). It is notable that a similar left-sided lateralization of hemodynamic responses was noticed by Seiyama et al in their study of human visual cortex activation by NIR topography (Seiyama et al, 2004).…”

Section: Discussionsupporting

confidence: 61%

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A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex

2007

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Functional near infrared spectro-imaging (fNIRSI) is potentially a very useful technique for obtaining information about the underlying physiology of the blood oxygenation level dependent (BOLD) signal used in functional magnetic resonance imaging (fMRI). In this paper the temporal and spatial statistical characteristics of fNIRSI data are compared to those of simultaneously acquired fMRI data in the human visual cortex during a variable-frequency reversing checkerboard activation paradigm. Changes in the size of activated volume caused by changes in checkerboard reversal frequency allowed a comparison of the behavior of the spatial responses measured by the two imaging methods. fNIRSI and fMRI data were each analyzed using standard correlation and fixed-effect group analyses of variance pathways. The statistical significance of fNIRSI data was found to be much lower than that of the fMRI data, due mainly to the low signal-to-noise of the measurements. Reconstructed images also showed that, while the time-course of changes in the oxy-, deoxy-, and total hemoglobin concentrations all exhibit high correlation with that of the BOLD response, the changes in the volume of tissue measured as "activated" by the BOLD response demonstrate a closer similarity to the corresponding changes in the oxy-and total hemoglobin concentrations than to that of the deoxyhemoglobin.

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Section: Resultssupporting

confidence: 93%

Section: Discussionsupporting

confidence: 61%

A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex

2007

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“…The patterns of shape asymmetries were similar across sex and diagnosis and were not significantly influenced by handedness, sex or by diagnostic group interactions with hand preference, as determined by permutation testing. Hemispheric shape asymmetries demonstrated features of cerebral torque that are consistent with the well-described patterns of right-frontal and left-occipital hemispheric protrusions documented in earlier imaging and postmortem studies (LeMay, 1976;Chui and Damasio, 1980;Bear et al, 1986;Koff et al, 1986;Zilles et al, 1996). Specifically, radial distance measures were larger in right compared to left hemisphere frontal regions, and larger in left compared to right occipital regions, in line with CT observations that frontal aspects of the right hemispheres are typically wider and longer than the left, and that parietal-occipital regions are wider and longer in the left hemisphere (LeMay, 1976;Chui and Damasio, 1980;Koff et al, 1986).…”

Section: Discussionsupporting

confidence: 78%

“…Hemispheric shape asymmetries demonstrated features of cerebral torque that are consistent with the well-described patterns of right-frontal and left-occipital hemispheric protrusions documented in earlier imaging and postmortem studies (LeMay, 1976;Chui and Damasio, 1980;Bear et al, 1986;Koff et al, 1986;Zilles et al, 1996). Specifically, radial distance measures were larger in right compared to left hemisphere frontal regions, and larger in left compared to right occipital regions, in line with CT observations that frontal aspects of the right hemispheres are typically wider and longer than the left, and that parietal-occipital regions are wider and longer in the left hemisphere (LeMay, 1976;Chui and Damasio, 1980;Koff et al, 1986). CT studies using visual categorizations and/or linear measurements from arbitrary brain slices to estimate cerebral torque, however, frequently report that right-biased frontal asymmetries are less frequent and distinct as compared to left-biased occipital asymmetries (LeMay, 1976;Chui and Damasio, 1980;Bear et al, 1986;Koff et al, 1986).…”

Section: Discussionsupporting

confidence: 78%

Asymmetries of cortical shape: Effects of handedness, sex and schizophrenia

Narr¹,

Bilder²,

Lüders³

et al. 2007

NeuroImage

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Some evidence suggests that sex, handedness and disease processes associated with schizophrenia affect the magnitude and/or direction of structural brain asymmetries. There are mixed findings, however, on how these factors influence cerebral torque, when torque is assessed with linear or volumetric measurements. We obtained MRI data from 67 healthy (30 males, 10 non-dextrals) and 84 schizophrenia subjects (60 males; 16 non-dextrals) and applied cortical pattern matching to spatially relate and compare differences in the surface morphology of the two cerebral hemispheres at high spatial resolution. Asymmetry indices, computed at thousands of matched hemispheric locations, were used to examine effects of sex, handedness and schizophrenia on hemispheric shape asymmetries while controlling for age and the other factors. Highly significant and discriminative right-frontal and left parietal-occipital surface expansions and protrusions (petalias) were mapped within groups. Although hemispheric shape asymmetries appeared less pronounced within female non-dextrals, asymmetry indices were not shown to differ significantly across sex, hand preference or diagnosis, or to reveal interactions of handedness with sex or diagnosis. Our 3D maps of spatially detailed anterior and posterior hemispheric shape asymmetries reflect subtle geometric distortions in hemispheric surface morphology that cannot be characterized with 2D or volumetric methods. Inter-individual variations in hemispheric torque appear minimally influenced by sex, dextrality or disease status. Biological factors driving language dominance or other lateralized brain functions dissociable from handedness, may more closely relate to hemispheric shape asymmetries, while the lateralization of other discrete brain

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“…The main and most consistent observations include the right frontal and left occipital petalia; marked indentations of the inner table of the skull resulting from the greater protrusion of the adjacent cerebral lobes 3,6) . The left occipital pole is frequently wider and protrudes further posterior than the right 3,7,9,11) . If the posterior region of the left hemisphere is more often larger than the right 3) , the posture of the cranium tends to tilt to the flat side.…”

Section: Discussionmentioning

confidence: 99%

What Determines the Laterality of the Chronic Subdural Hematoma?

Kim

Lee

Shim

et al. 2010

J Korean Neurosurg Soc

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Objective : Chronic subdural hematomas (CSDH) are more common on the left hemisphere than on the right. We verified this left predilection of CSDH and tried to explain the reason for this discrepancy. Methods : We investigated the laterality of CSDH in 182 patients who were treated from January 2005 to December 2009. We examined the symmetry of the cranium and the location of the lesion. Results : CSDH was more common on the left-side. The cranium was symmetric in 63 patients, asymmetric in 119 patients. The asymmetric crania were flat on the right-side in 77 patients, on the left-side in 42 patients. The density of the CSDHs was hypodense in 29 patients, isodense 132 patients, and the others in 21 patients. Bilateral hematomas were more common in the hypodense group. In the right flat crania, the hematoma was more commonly located on the opposite side of the flat side. While in the left flat crania, the hematoma was more common on the same side. Conclusion : CSDHs occurred more frequently on the left side. The anatomical asymmetry of the cranium influences the left predilection of CSDH.

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Computed Tomographic Scan Hemispheric Asymmetries in Right- and Left-handed Male and Female Subjects

Cited by 84 publications

References 22 publications

A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex

A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex

Asymmetries of cortical shape: Effects of handedness, sex and schizophrenia

What Determines the Laterality of the Chronic Subdural Hematoma?

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