Computed Tomography‐Based Assessment of Abdominal Adiposity Changes and Their Impact on Metabolic Alterations Following Bariatric Surgery

Galanakis, Christos; Daskalakis, Markos; Manios, Andreas; Xyda, A.; Karantanas, Apostolos H.; Melissas, John

doi:10.1007/s00268-014-2826-2

Cited by 31 publications

(17 citation statements)

References 48 publications

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“…Finally, favorable redistribution of body fat after RYGB was observed. These results are in line with previous findings 141,159,160 , and may potentially involve a higher lipid turn-over rate in visceral adipose tissue 161 .…”

Section: Study Specific Aspectssupporting

confidence: 93%

Body fat mass and distribution as predictors of metabolic outcome and weight loss after Roux-en-Y gastric bypass

Hogling

Rydén

Bäckdahl

et al. 2018

Surgery for Obesity and Related Diseases

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Section: Study Specific Aspectssupporting

confidence: 93%

Body fat mass and distribution as predictors of metabolic outcome and weight loss after Roux-en-Y gastric bypass

Hogling

Rydén

Bäckdahl

et al. 2018

Surgery for Obesity and Related Diseases

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“…Therefore, adipose tissue has been hypothesized to be a main source of exosomal miRNAs . The most obvious effect of bariatric surgery is the reduction in adipose tissue mass in the first year after surgery . Decreased exosomal miRNA levels after bariatric surgery support the hypothesis that adipose tissue is a main source of exosomal miRNAs.…”

Section: Discussionmentioning

confidence: 95%

Bariatric Surgery Alters microRNA Content of Circulating Exosomes in Patients with Obesity

Bae

Lee

Kim

et al. 2019

Obesity

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Objective: Exosomal microRNAs (miRNAs) are potential biomarkers for obesity, in which they regulate biological processes. Bariatric surgery has health benefits for patients with obesity; however, the mechanisms of these benefits are not clear. This study attempted to identify the exosomal miRNA signature associated with obesity and how it changed after bariatric surgery. Methods: Healthy volunteers (HVs) and nondiabetic patients with obesity were prospectively enrolled in the study. The study assessed the serum exosomal miRNA profiles of HVs and patients with obesity using RNA sequencing. To evaluate the effects of bariatric surgery, the study also analyzed exosomal miRNAs in patients 6 months after surgery. Results: RNA sequencing revealed differential expression of 72 exosomal miRNAs in patients with obesity compared with HVs and differential expression of 41 miRNAs in post-versus presurgery blood. Among the differentially expressed miRNAs, the study identified nine surgery-responsive miRNAs that were highly expressed in patients before surgery compared with HVs. Biological pathway analysis of the nine miRNAs indicated that they are likely involved in WNT, neurotrophin, and insulin signaling; the insulin receptor signaling cascade; and focal adhesion. Conclusions: Patients with obesity have a distinct exosomal miRNA expression profile compared with HVs. In addition, weight loss after surgery alters the exosomal miRNA profile of patients with obesity.

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“…This presumption is based on the pathophysiology of non-alcoholic fatty liver disease, insulin resistance [103], cardiovascular disease, and even cancers [104]. Metabolic surgery can significantly reduce white adipose tissues mass [105] and has been shown to downregulate the serum inflammatory mediators interleukin-6 and tumor necrosis factor and upregulate adiponectin. The bodily 5 0 -adenosine monophosphate-activated protein kinase (AMPK) is a critical energy sensor that senses and is activated by the lower ratio of adenosine triphosphate to adenosine monophosphate.…”

Section: Inflammatory Responsementioning

confidence: 99%

Potential mechanisms of sleeve gastrectomy for reducing weight and improving metabolism in patients with obesity

Huang

Ding

et al. 2019

Surgery for Obesity and Related Diseases

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Obesity is a severe medical problem endangering the health of individuals worldwide. Sleeve gastrectomy (SG), one of the most commonly performed bariatric procedures, has been widely applied to the treatment of such patients. Currently, the potential mechanisms underlying the significant weight loss and metabolic improvement after SG have been well studied. First, and most importantly, by removing a large volume of stomach, the SG directly or indirectly restricts food intake. Then, there are alterations in the absorption and metabolism of both macro-and micronutrients, which may benefit or worsen the patients' well-being. Another profound change is enhanced secretion of the satiety gut hormone and reduced secretion of the hunger hormone as a consequence of the operation. Additionally, adjustment of gastrointestinal motility, alteration in the gut microbial community, and an inflammatory response were found after surgery. Therefore, the purpose of the present review was focused on such hypotheses and to compile the accumulated facts on the physiologic mechanism of bariatric surgery so that these results can help improve the understanding of how SG produces substantial weight loss and a significant improvement in the metabolism of patients with metabolic syndrome.

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Computed Tomography‐Based Assessment of Abdominal Adiposity Changes and Their Impact on Metabolic Alterations Following Bariatric Surgery

Abstract: Significant changes in abdominal lipid deposition occurred in MO patients 6 and 12 months after bariatric surgery. The changes were significantly, correlated with the magnitude of BMI loss. The fat redistribution may contribute to the improvements in metabolic abnormalities.

Cited by 31 publications

References 48 publications

Body fat mass and distribution as predictors of metabolic outcome and weight loss after Roux-en-Y gastric bypass

Body fat mass and distribution as predictors of metabolic outcome and weight loss after Roux-en-Y gastric bypass

Bariatric Surgery Alters microRNA Content of Circulating Exosomes in Patients with Obesity

Potential mechanisms of sleeve gastrectomy for reducing weight and improving metabolism in patients with obesity

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