Computed Tomography–Based Predictive Model for the Probability of Lymph Node Metastasis in Gastric Cancer: A Meta-analysis

Teng, Fei; Fu, Yu‐Fei; Wu, Aihua; Xian, Yu-Tao; Lin, Jia Wei; Huang, Rui; Yin, Yong-Fang

doi:10.1097/rct.0000000000001530

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Moreover, measurement errors cannot be entirely avoided when manually de ning lesion boundaries, and factors such as edema, hemorrhage, necrosis, and degeneration can contribute to such errors. Third, radiomics strategies are often limited in their reproducibility and amenability to standardization, potentially restricting their utility [23].…”

Section: Discussionmentioning

confidence: 99%

A MRI radiomics-based model for prediction of pelvic lymph node metastasis in cervical cancer

Wang,

Li,

et al. 2023

Preprint

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Background Cervical cancer (CC) is a common malignancy of the female reproductive tract, and preoperative prediction of lymph node metastasis (LNM) is essential. This study aim to design and validate a magnetic resonance imaging (MRI) radiomics-based predictive model capable of detecting LNM in patients diagnosed with CC. Methods This retrospective analysis incorporated 86 and 38 CC patients into the training and testing groups, respectively. Radiomics features were extracted from MRI T2WI, T2WI-SPAIR, and axial apparent diffusion coefficient (ADC) sequences. Selected features identified in the training group were then used to construct a radiomics scoring model, with relevant LNM-related risk factors having been identified through univariate and multivariate logistic regression analyses. The resultant predictive model was then validated in the testing cohort. Results In total, 16 features were selected for the construction of a radiomics scoring model. LNM-related risk factors included worse differentiation (P < 0.001), more advanced International Federation of Gynecology and Obstetrics (FIGO) stages (P = 0.03), and a higher radiomics score from the combined MRI sequences (P = 0.01). The equation for the predictive model was as follows: -0.0493-2.1410×differentiation level + 7.7203×radiomics score of combined sequences + 1.6752×FIGO stage. The respective area under the curve (AUC) values for the T2WI radiomics score, T2WI-SPAIR radiomics score, ADC radiomics score, combined sequence radiomics score, and predictive model were 0.656, 0.664, 0.658, 0.835, and 0.923 in the training cohort, while these corresponding AUC values were 0.643, 0.525, 0.513, 0.826, and 0.82 in the testing cohort. Conclusions This MRI radiomics-based model exhibited favorable accuracy when used to predict LNM in patients with CC. Relative to the use of any individual MRI sequence-based radiomics score, this predictive model yielded superior diagnostic accuracy.

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Section: Discussionmentioning

confidence: 99%

A MRI radiomics-based model for prediction of pelvic lymph node metastasis in cervical cancer

Wang,

Li,

et al. 2023

Preprint

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A MRI radiomics-based model for prediction of pelvic lymph node metastasis in cervical cancer

Wang,

Li,

et al. 2024

World J Surg Onc

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Background Cervical cancer (CC) is a common malignancy of the female reproductive tract, and preoperative prediction of lymph node metastasis (LNM) is essential. This study aims to design and validate a magnetic resonance imaging (MRI) radiomics-based predictive model capable of detecting LNM in patients diagnosed with CC. Methods This retrospective analysis incorporated 86 and 38 CC patients into the training and testing groups, respectively. Radiomics features were extracted from MRI T2WI, T2WI-SPAIR, and axial apparent diffusion coefficient (ADC) sequences. Selected features identified in the training group were then used to construct a radiomics scoring model, with relevant LNM-related risk factors having been identified through univariate and multivariate logistic regression analyses. The resultant predictive model was then validated in the testing cohort. Results In total, 16 features were selected for the construction of a radiomics scoring model. LNM-related risk factors included worse differentiation (P < 0.001), more advanced International Federation of Gynecology and Obstetrics (FIGO) stages (P = 0.03), and a higher radiomics score from the combined MRI sequences (P = 0.01). The equation for the predictive model was as follows: −0.0493–2.1410 × differentiation level + 7.7203 × radiomics score of combined sequences + 1.6752 × FIGO stage. The respective area under the curve (AUC) values for the T2WI radiomics score, T2WI-SPAIR radiomics score, ADC radiomics score, combined sequence radiomics score, and predictive model were 0.656, 0.664, 0.658, 0.835, and 0.923 in the training cohort, while these corresponding AUC values were 0.643, 0.525, 0.513, 0.826, and 0.82 in the testing cohort. Conclusions This MRI radiomics-based model exhibited favorable accuracy when used to predict LNM in patients with CC. Relative to the use of any individual MRI sequence-based radiomics score, this predictive model yielded superior diagnostic accuracy.

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Preoperative predictive model for the probability of lymph node metastasis in gastric cancer: a retrospective study

Teng,

Zhu,

Zhou

et al. 2024

Front. Oncol.

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BackgroundEffectively diagnosing lymph node (LN) metastasis (LNM) is crucial in determining the condition of patients with gastric cancer (GC). The present study was devised to develop and validate a preoperative predictive model (PPM) capable of assessing the LNM status of individuals with GC.MethodsA retrospective analysis of consecutive GC patients from two centers was conducted over the period from January 2021 to December 2023. These patients were utilized to construct a 289-patient training cohort for identifying LNM-related risk factors and developing a PPM, as well as a 90-patient testing cohort used for PPM validation.ResultsOf the GC patients included in the training cohort, 67 (23.2%) and 222 (76.8%) were respectively LNM negative and positive. Risk factors independently related to LNM status included cT3 invasion (P = 0.001), CT-reported LN (+) (P = 0.044), and CA199 value (P = 0.030). LNM risk scores were established with the following formula: score = -2.382 + 0.694×CT-reported LN status (+: 1; -: 0)+2.497×invasion depth (cT1: 0; cT2: 1; cT3: 2)+0.032×CA199 value. The area under the curve (AUC) values for PPM and CT-reported LN status were 0.753 and 0.609, respectively, with a significant difference between them (P < 0.001). When clinical data from the testing cohort was included in the PPM, the AUC values for the PPM and CT-reported LN status were 0.756 and 0.568 (P < 0.001).ConclusionsThe established PPM may be an effective technique for predicting the LNM status of patients preoperatively. This model can better diagnose LNM than CT-reported LN status alone, this model is better able to diagnose LNM.

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Computed Tomography–Based Predictive Model for the Probability of Lymph Node Metastasis in Gastric Cancer: A Meta-analysis

Cited by 3 publications

References 31 publications

A MRI radiomics-based model for prediction of pelvic lymph node metastasis in cervical cancer

A MRI radiomics-based model for prediction of pelvic lymph node metastasis in cervical cancer

A MRI radiomics-based model for prediction of pelvic lymph node metastasis in cervical cancer

Preoperative predictive model for the probability of lymph node metastasis in gastric cancer: a retrospective study

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