Computed tomography (CT) of cervical lymph nodes in patients with oral cancer: comparison of low-attenuation areas in lymph nodes on CT images with pathological findings

Fukunari, Fumiko; Okamura, Kazuhiko; Kagawa, Toyohiro; Zeze, Ryousuke; Yuasa, Kenji

doi:10.1007/s11282-008-0070-x

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…It is estimated that approximately 25% of tumourpositive elective neck dissections of clinically N0 necks contain micrometastasis smaller than 3mm, therefore virtually undetectable by today's imaging technologies [43]. The range for negative predictive value of staging CT scans is between 56 and 78% [44][45][46][47], indicating that in some instances almost half of patients diagnosed with an N0 neck ended up having occult neck metastasis on pathological evaluation. Furthermore, some metastatic nodes contain tumour cells that remain undetected even on histological slides prepared with conventional haematoxylin and eosin staining, and may only be detected by immunohistochemically and molecular analysis [48].…”

Section: Advanced Imaging Techniquesmentioning

confidence: 99%

The N0 Neck in Oral Squamous Cell Carcinoma A Comprehensive Review and Update on Diagnosis and Management

Patel¹

2020

GJO

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Oral cavity cancer represents one of the most devastating diseases worldwide, as the morbidity and mortality associated with it can be quite significant. Spread to cervical lymph nodes represents a major contributor to patient prognosis, however, despite many technological advances, accurate and consistent identification of involvement of the neck in early stage oral squamous cell carcinoma remains a major challenge. With increasingly sensitive and specific imaging modalities, cytological analysis, as well as sentinel node biopsy, identification of regional cervical metastasis continuously improves. The spread of this disease to regional lymph nodes of the neck often results in dramatic changes in treatment and prognosis, and thus management of the neck in early oral cancer is of paramount importance. A consensus on the ideal treatment modality for the clinically node-negative neck still eludes us, with elective neck dissection at the time of primary treatment being the current gold standard, with radiation and chemotherapy having adjunctive roles. The "wait and see" philosophy also has its advocates, as well as its critics. Advances in genetic analysis of tumours may represent the future in patient-specific intervention. This article represents a review of past, present, as well as future advances in the diagnosis and management of the N0 neck in oral cancer, highlighting the most recent research, techniques, and practices worldwide.

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Section: Advanced Imaging Techniquesmentioning

confidence: 99%

The N0 Neck in Oral Squamous Cell Carcinoma A Comprehensive Review and Update on Diagnosis and Management

Patel¹

2020

GJO

View full text Add to dashboard Cite

show abstract

Computed tomography (CT) of cervical lymph nodes in patients with oral cancer: comparison of low-attenuation areas in lymph nodes on CT images with pathological findings

Cited by 1 publication

References 15 publications

The N0 Neck in Oral Squamous Cell Carcinoma A Comprehensive Review and Update on Diagnosis and Management

The N0 Neck in Oral Squamous Cell Carcinoma A Comprehensive Review and Update on Diagnosis and Management

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