Computed tomography features of recurrent ovarian carcinoma according to time to relapse

Sahdev, Anju; Hughes, John; Barwick, Tara; Rockall, Andrea; Gallagher, Chris; Reznek, Rodney H.

doi:10.1080/02841850701557255

Cited by 18 publications

(9 citation statements)

References 20 publications

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“…We demonstrated in the present study that ovarian cancers recur most commonly as peritoneal metastases and lymph node metastasis, supporting the evidence that common sites of ovarian cancer recurrence include the pelvic mass, peritoneal metastases and enlarged lymph nodes (14,15), the pleura, and the lung (15). Furthermore, we specified the common anatomical location of peritoneal metastases as solid nodules rather than cystic lesions.…”

Section: Discussionsupporting

confidence: 89%

Detecting recurrent ovarian cancer: revisit the values of whole-body CT and serum CA 125 levels

Wang

Huang

et al. 2019

Acta Radiol

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Background Computed tomography (CT) has served as the first-line imaging modality but its role for detecting recurrent ovarian cancer should be revisited in the era of whole-body CT. Purpose To study anatomical distributions and imaging patterns of recurrent ovarian epithelial cancer through whole-body CT and their associations with serum cancer antigen 125 (CA 125) levels. Material and Methods This retrospective study approved by the institutional review board comprised a cohort of 497 patients with ovarian cancer. The specific anatomical locations and imaging features of recurrent lesions on CT at the time of recurrence were analyzed. Results Fifty-nine patients had ovarian cancer recurrence. The median time from diagnosis to recurrence was 17 months (range = 8–51). Among the 144 recurrent lesions, the leading recurrent sites were the intraperitoneal cavity and lymph nodes. Cystic lesions were significantly more frequently located intraperitoneally (P = 0.026), in particular with locoregional recurrence (P = 0.006). Serum CA 125 levels in the patients were significantly higher in the presence of peritoneal metastases (P = 0.010), locoregional lesions at the cul-de-sac or vaginal stump (P = 0.002), and metastases to infradiaphragmatic organs (P = 0.013). Among the 18 patients with CA 125 levels ≤ 35 U/mL at recurrence, 10 patients had supradiaphragmatic lesions in the lung and brain. None of the studied patients had bony metastasis at recurrence. Conclusion In patients with suspected recurrence, extended-field CT to cover the thoracic region might be useful during follow-up of patients with ovarian cancer, regardless of CA 125 levels.

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Section: Discussionsupporting

confidence: 89%

Detecting recurrent ovarian cancer: revisit the values of whole-body CT and serum CA 125 levels

Wang

Huang

et al. 2019

Acta Radiol

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“…In our patient, the time to recurrence, 23 years after the diagnosis, was unusually long. A retrospective study including 400 patients with ovarian cancer showed that 87% of relapses occurred within 5 years following primary treatment, 8% relapsed between 5-10 years and 6% relapsed after 10 years (5). Very late relapses, after more than 20 years have only rarely been reported for invasive ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Late Recurrent Ovarian Carcinoma Metastatic to the Thoracic Wall

Testelmans

Raemdonck

Amant

et al. 2010

Acta Clinica Belgica

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Ovarian cancer is the second most common gynaecologic malignancy. Ovarian carcinomas typically metastasize to multiple sites via exfoliation, lymphatic spread or direct invasion. We present a rare case of a very late recurrence of ovarian carcinoma into the thoracic wall, heralded by thoracic pain in a patient otherwise disease-free for 23 years. This unusual and late presentation of an ovarian cancer metastasis underscores the need for continued awareness and attention to new symptoms in patients with ovarian cancer who show prolonged disease-free intervals.

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“…These studies demonstrated that, although EOC typically colonized a wide variety of organs and tissues, there was not one single metastatic site that was always involved by metastasis in all studied cases. The main site of metastasis was the peritoneum, including the parietal and visceral peritoneum and omentum, which was involved in 77% of cases on average among several reports (ranging between 53% and 99%, Table 1 ) [ 25 , 26 , 27 , 29 , 30 , 31 ]. Other commonly colonized sites identified by autopsy studies included lymph nodes (38–77% of cases), large and small intestine (44–86% of cases), liver parenchyma (45–59% of cases), and lung (33–39% of cases).…”

Section: Sites Of Eoc Metastasesmentioning

confidence: 99%

Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma

Barbolina

2018

Cancers

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Epithelial ovarian carcinoma is the most predominant type of ovarian carcinoma, the deadliest gynecologic malignancy. It is typically diagnosed late when the cancer has already metastasized. Transcoelomic metastasis is the most predominant mechanism of dissemination from epithelial ovarian carcinoma, although both hematogenously and lymphogenously spread metastases also occur. In this review, we describe molecular mechanisms known to regulate organ-specific metastasis from epithelial ovarian carcinoma. We begin by discussing the sites colonized by metastatic ovarian carcinoma and rank them in the order of prevalence. Next, we review the mechanisms regulating the transcoelomic metastasis. Within this chapter, we specifically focus on the mechanisms that were demonstrated to regulate peritoneal adhesion—one of the first steps in the transcoelomic metastatic cascade. Furthermore, we describe mechanisms of the transcoelomic metastasis known to regulate colonization of specific sites within the peritoneal cavity, including the omentum. Mechanisms underlying hematogenous and lymphogenous metastatic spread are less comprehensively studied in ovarian cancer, and we summarize mechanisms that were identified to date. Lastly, we discuss the outcomes of the clinical trials that attempted to target some of the mechanisms described in this review.

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Computed tomography features of recurrent ovarian carcinoma according to time to relapse

Abstract: Our study is the first to describe common patterns of recurrence in ovarian cancer. Most frequent site is pelvis, followed by peritoneum, serosal surfaces and nodal disease. 30% presented with disease at 'unusual' sites.

Cited by 18 publications

References 20 publications

Detecting recurrent ovarian cancer: revisit the values of whole-body CT and serum CA 125 levels

Detecting recurrent ovarian cancer: revisit the values of whole-body CT and serum CA 125 levels

Late Recurrent Ovarian Carcinoma Metastatic to the Thoracic Wall

Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma

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