Computed Tomography Follow-Up Assessment of Patients with Low-Grade Appendiceal Mucinous Neoplasms: Evaluation of Risk for Pseudomyxoma Peritonei

Tiselius, Catarina; Kindler, Csaba; Shetye, Jayant; Letocha, Henry; Smedh, Kenneth

doi:10.1245/s10434-016-5623-3

Cited by 42 publications

(20 citation statements)

References 22 publications

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“…The reoccurrence of LAMN is very rare with intact removal of a mucocele. However, the potential to develop a malignant condition is increased in patients with positive margin; appendiceal rupture; mucin, cells, or both outside the appendix; or pseudomyxoma peritonei (PMP) [3][4][5][6]. PMP is the most malignant condition in these situations with a high relapse rate [1].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients

Xiao

Liu

2020

Journal of Investigative Surgery

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Introduction: Low-grade appendiceal mucinous neoplasm (LAMN) is a rare disorder. There is no consensus on the prognosis and management of LAMN. Materials and methods: We reviewed 51 consecutive patients with LAMN from 2013 to 2018. We divided our patients into two groups. The first is patients with an intact appendix. The second group comprises patients with the potential to develop a malignant condition. Comparisons of serum tumor markers between two groups were performed. Survival curves were estimated. Univariate and multivariate Cox proportional hazards were computed for 46 patients with median follow-up of 2.7 years. Results: Comparison of patients in two groups revealed significant differences in the mean level and abnormal ratio of CA125 (p < 0.001, p < 0.001), CA19-9 (p ¼ 0.04, p ¼ 0.04), and CEA (p ¼ 0.001, p ¼ 0.02). Eight patients had relapsed by the last follow-up in the second group. Patients with normal CEA had significantly longer disease-free survival (DFS) time than those with abnormal CEA (p ¼ 0.04). CA19-9 exhibited a significant association with DFS (HR ¼ 5.72, p ¼ 0.02) in the Univariate Cox proportional hazards. Discussion: The prognosis of LAMN is related to serum tumor markers, the surgical procedure and the pathology.

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Section: Introductionmentioning

confidence: 99%

“…To perform better surveillance of patients with LAMN with the potential to develop a malignant condition, many investigations have been performed. Relapse rates are evaluated in patients [3][4][5][6]. It also raises our interest in focusing on these patients.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients

Xiao

Liu

2020

Journal of Investigative Surgery

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“…Surveillance of patients with LAMN incorporates radiographic imaging every six months post appendectomy for two years for adequate monitoring of tumor recurrence and complications associated with PMP [10]. Accurate pathological assessment and classification of LAMN are important to assess for malignancy risk, seeding, recurrence, and patient prognosis [1].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Low-grade Appendiceal Mucinous Neoplasm: A Case Report

González¹,

Herard²,

Mijares³

2019

Cureus

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Low-grade appendiceal mucinous neoplasm (LAMN) is a rare malignancy with symptoms varying depending on the clinical manifestations. The most worrisome complication of this particular neoplasm is seeding of mucin into the adjacent peritoneum leading to pseudomyxoma peritonei (PMP). There is a lack of standardized treatment approach; however, an appendectomy-only approach is currently being used for the resection of non-metastatic disease. We present an unusual case of a 67-year-old male found to have LAMN status post elective appendectomy, six months after being treated for an appendiceal abscess.

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“…The involvement of the appendectomy margin by either neoplastic epithelium or acellular mucin is not associated with disease recurrence or peritoneal dissemination [ 32 ]. Surveillance of patients with LAMN incorporates radiographic imaging every six months for two years after appendectomy for adequate monitoring of tumor recurrence and complications associated with PMP [ 33 ]. While other articles suggested, follow-up should continue for five to 10 years with physical exams, annual CT, and monitoring of tumor markers.…”

Section: Discussionmentioning

confidence: 99%

A Unique Case of Low-Grade Mucinous Neoplasm in Stump Appendectomy

Al‐Tarakji

Ali

Shah

et al. 2020

Case Reports in Surgery

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Background. We describe a case of a young male with a history of appendectomy one year ago, who developed symptoms of stump appendicitis, and after removing this stump, histopathology showed low grade neoplasm. Summary. Stump appendicitis is an uncommon complication after appendectomy and may lead to serious complications. Management of low-grade appendiceal mucinous neoplasm (LAMN) is controversial, and we discuss the importance of the case. Conclusion. The case of young male post stump appendectomy with histopathology showing LAMN in the stump of the appendix, which to our knowledge, is the first in the medical literature and, discuss the stump appendicitis and incomplete appendectomy concerning malignancy, mucinous neoplasm, and adenocarcinoma.

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Computed Tomography Follow-Up Assessment of Patients with Low-Grade Appendiceal Mucinous Neoplasms: Evaluation of Risk for Pseudomyxoma Peritonei

Cited by 42 publications

References 22 publications

Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients

Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients

A Rare Case of Low-grade Appendiceal Mucinous Neoplasm: A Case Report

A Unique Case of Low-Grade Mucinous Neoplasm in Stump Appendectomy

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