Computed tomography for preoperative evaluations of lung cancer

Nakata, Hajime; Ishimaru, Hirofumi; Nakayama, C; Yoshimatsu, Hiroshi

doi:10.1016/0149-936x(86)90067-6

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…In nine studies lymph node size was measured in the short axis with CT, in one in the long axis with CT and four studies did not mention whether the short or long axis was measured. Using these different methods of size measurement, the prevalence of malignant involvement ranged from 9% to 42% for lymph nodes measuring 10-15 mm [15,16], 19-75% for lymph nodes measuring 16-20 mm [9,16] and 27-100% for lymph nodes measuring >20 mm [11,15].…”

Section: Resultsmentioning

confidence: 99%

“…Crossreferencing yielded another 23 potentially eligible studies. After full-text analysis, 14 were included [7][8][9][10][11][12][13][14][15][16][17][18][19][20], all of which had been identified with the initial Medline search. In nine studies lymph node size was measured in the short axis with CT, in one in the long axis with CT and four studies did not mention whether the short or long axis was measured.…”

Section: Resultsmentioning

confidence: 99%

“…We found 14 studies [7][8][9][10][11][12][13][14][15][16][17][18][19][20] that assessed the prevalence of metastatic involvement of enlarged lymph nodes of different size categories in patients with NSCLC. Although reports have been published that show no increase in prevalence of metastasis with increasing lymph node size or an increase at larger lymph node size (e.g.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The size of mediastinal lymph nodes and its relation with metastatic involvement: a meta-analysis

Langen

Raijmakers

Riphagen

et al. 2006

European Journal of Cardio-Thoracic Surgery

173

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Positron emission tomography with 18-fluorodeoxyglucose (FDG-PET) seems to be superior to computed tomography (CT) in staging the mediastinum in patients with non-small-cell lung cancer (NSCLC). However, recent results suggest that FDG-PET performance characteristics are conditional for nodal size as shown by CT: FDG-PET is more sensitive but less specific with lymph node enlargement on CT. The association between size and the probability of malignancy needs to be known to predict the post-test probabilities after PET, and finally, stratify patients for mediastinoscopy or thoracotomy depending on the PET and CT results. Therefore, we performed a meta-analysis of available studies reporting on the prevalence of metastatic involvement for different size categories of enlarged lymph nodes in patients with NSCLC and were able to include 14 studies. The prevalence of metastatic involvement and conditional test performance of CT and FDG-PET were calculated for lymph nodes measuring 10-15 mm, 16-20 mm and >20 mm. We found a post-test probability for N2 disease of 5% for lymph nodes measuring 10-15 mm on CT in patients with a negative FDG-PET result, suggesting that these patients should be planned for thoracotomy because the yield of mediastinoscopy will be extremely low. For patients with lymph nodes measuring > or =16 mm on CT and a negative FDG-PET result a post-test probability for N2 disease of 21% was found, suggesting that these patients should be planned for mediastinoscopy prior to possible thoracotomy to prevent too many unnecessary thoracotomies in this subset.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The size of mediastinal lymph nodes and its relation with metastatic involvement: a meta-analysis

Langen

Raijmakers

Riphagen

et al. 2006

European Journal of Cardio-Thoracic Surgery

173

View full text Add to dashboard Cite

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Sensitivity and specificity of computed tomography for the detection of adrenal metastatic lesions among 91 autopsied lung cancer patients

Allard

Yankaskas

Fletcher

et al. 1990

Cancer

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The ability of computed tomography (CT) to detect metastatic lesions in adrenal glands was evaluated on 91 autopsied lung cancer patients who died in 11 hospitals in the eastern United States and Canada from January 1983 to February 1988. Abdominal CT scans within 90 days of death were reviewed twice by two radiologists blinded to the autopsy diagnosis. The likelihood of metastatic spread in each adrenal gland was scored on a five-level scale. Histopathologic findings at autopsy were used to establish the presence or absence of metastases. The sensitivity of CT was low. Among 53 adrenal glands with proven metastatic lesions, the proportion with positive CT scans varied from 20.0% to 41.1%, according to the positivity threshold. In contrast, the specificity of CT was high, even at relaxed positivity thresholds, from 84.5% to 99.4%. The relatively low sensitivity of CT to detect adrenal metastatic lesions is explained to a large extent by the lack of substantial structural changes in many adrenal glands found to have metastases at autopsy. With a strongly positive CT scan, the probability of an adrenal metastatic lesion is high, and confirmatory adrenal biopsy may not be needed in patients with adenocarcinoma and large cell carcinoma.

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The diagnosis and treatment of lung cancer presented as ground-glass nodule

Chen

2019

Gen Thorac Cardiovasc Surg

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Computed tomography for preoperative evaluations of lung cancer

Cited by 4 publications

References 13 publications

The size of mediastinal lymph nodes and its relation with metastatic involvement: a meta-analysis

The size of mediastinal lymph nodes and its relation with metastatic involvement: a meta-analysis

Sensitivity and specificity of computed tomography for the detection of adrenal metastatic lesions among 91 autopsied lung cancer patients

The diagnosis and treatment of lung cancer presented as ground-glass nodule

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