Computed Tomography–Guided High-Dose-Rate Brachytherapy in Hepatocellular Carcinoma: Safety, Efficacy, and Effect on Survival

Mohnike, Konrad; Wieners, Gero; Schwartz, Franziska Angelika; Seidensticker, Max; Pech, Maciej; Ruehl, Ricarda; Wust, Peter; Lopez-Hänninen, E.; Gademann, G.; Peters, Nils; Berg, Thomas; Malfertheiner, Peter; Ricke, Jens

doi:10.1016/j.ijrobp.2009.07.1700

Cited by 108 publications

(72 citation statements)

References 46 publications

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“…The technique of CT-guided high-dose-rate brachytherapy (CT-HDRBT) of hepatic malignancies was established in 2002 and has been used since then with promising outcome, e.g., in colorectal cancer metastases or hepatocellular carcinoma [17,18]. CT-HDRBT has proven valuable especially in those lesions unfavorable for RFA because of large diameters (up to 10-13 cm), complex shape, or close relation to central bile ducts or vessels, conditions that are common in irresectable IHC [19].…”

Section: Introductionmentioning

confidence: 99%

Computed Tomography-Guided Interstitial HDR Brachytherapy (CT-HDRBT) of the Liver in Patients with Irresectable Intrahepatic Cholangiocarcinoma

Schnapauff

Denecke

Grieser

et al. 2011

Cardiovasc Intervent Radiol

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Section: Introductionmentioning

confidence: 99%

Computed Tomography-Guided Interstitial HDR Brachytherapy (CT-HDRBT) of the Liver in Patients with Irresectable Intrahepatic Cholangiocarcinoma

Schnapauff

Denecke

Grieser

et al. 2011

Cardiovasc Intervent Radiol

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“…In particular, patients with metastases of colorectal origin [83] but also those with locally restricted HCC [34,84] may benefit from this approach with a prolongation of survival. A basic prediction for the broad use of brachytherapeutic interventions is an interdisciplinary collaboration.…”

Section: Discussionmentioning

confidence: 99%

“…The mean local control rate of all groups was 34 months(according to Kaplan-Meier assessment) whereby it significantly increased -as expected -with higher dose of radiation (25.6, 31.1 and 46.6 months, respectively). Mohnikeet al [84]. Showed a significantly better survival in 83 patients with HCC who had undergone prospective BT compared (by "matched-pair" analysis) with a group of patients with no radiation.…”

Section: Brachytherapy In Intraluminal Tumor Lesionsmentioning

confidence: 99%

Value of Brachytherapy as Part of Interdisciplinary Therapeutic Concepts for Solid Tumor Lesions – Brachytherapeutic Options and Spectrum of Treatment Results at the Center of Radiology (Department of Radiotherapy - University Hospital of Magdeburg)

Hass¹

2016

Austin J Radiat Oncol & Cancer

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As in many other medical disciplines, a substantial change of paradigms in oncology and oncotherapy can be observed. In particular, for the treatment of solid tumor lesions the former rather rigid approach to differentiate between curative (no detection of distant metastases) and palliative intention (including systemic advancement of tumor disease) has been increasingly overcome. The concept of oligometastases has been getting more and more attention. Oligometastatic status can be classified if in first diagnosis or in follow-up investigation for tumor staging only a few distant metastases are found. According to the former guidelines, this might only lead to initiation of a palliative treatment, in the majority of cases to a systemic type of therapy! Interestingly, there has been substantial evidence that local ablation of the small number of filiae can favorably influence quality of life (the main intent of "palliative care" according to the definition by WHO) and prognosis. However, there are no predictive markers yet such as laboratory parameters, which allow to assess prognosis of a certain tumor stage / disease including oligometastases.Surgical resection was and is the gold standard of local ablation but only a certain percentage of patients with oligometastases can be approached with surgical intervention since several of them areunresectable from a technical or inoperable from an anesthesiological point of view. In addition to surgical ablation, there have been a number of non-or minimally invasive techniques available such as thermo-, chemo-and radioablading procedures.This review aims at Brachytherapy (BT) as radioablating method, its indications as part of curative concepts, the possible treatment spectrum shown in detail at the University Hospital of Magdeburg (Germany), and, in particular, indicating what is feasible and achievable from a qualitative and quantitative point of view. Finally, exemplary and representative cases document the potential benefit in radioablation of metastases.

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“…In addition, in two recent publications of prospective randomised trials, the method has proven to have a significant prognostic impact on advanced HCC as well as metastatic colorectal carcinoma [34,35]. MR-compatible tools needed to perform image-guided brachytherapy in MRI are limited to a puncture needle, a polyurethane sheath and a polyurethane brachytherapy catheter.…”

Section: Discussionmentioning

confidence: 99%

MR-guided liver tumor ablation employing open high-field 1.0T MRI for image-guided brachytherapy

et al. 2010

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Computed Tomography–Guided High-Dose-Rate Brachytherapy in Hepatocellular Carcinoma: Safety, Efficacy, and Effect on Survival

Cited by 108 publications

References 46 publications

Computed Tomography-Guided Interstitial HDR Brachytherapy (CT-HDRBT) of the Liver in Patients with Irresectable Intrahepatic Cholangiocarcinoma

Computed Tomography-Guided Interstitial HDR Brachytherapy (CT-HDRBT) of the Liver in Patients with Irresectable Intrahepatic Cholangiocarcinoma

Value of Brachytherapy as Part of Interdisciplinary Therapeutic Concepts for Solid Tumor Lesions – Brachytherapeutic Options and Spectrum of Treatment Results at the Center of Radiology (Department of Radiotherapy - University Hospital of Magdeburg)

MR-guided liver tumor ablation employing open high-field 1.0T MRI for image-guided brachytherapy

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