Cardiac computed tomography (CT) is a robust technology for the noninvasive assessment of a spectrum of cardiovascular disease processes. The predominant use of cardiac CT is fi rst detection of atherosclerosis and subsequently detection of stenosis, perfusion imaging, wall motion and ultimately valve disease. Although the technology has been clinically available for more than 25 years, cardiologists and even radiologists are largely unaware of its full capabilities. This chapter reviews cardiac CT's current clinical uses and its potential for even greater utility in the near future. Advances in spatial and temporal resolution, electrocardiographic (ECG) triggering methodology, radiation dose reduction, and image reconstruction software have helped in the evaluation of coronary artery anatomy and vessel patency, providing the ability to noninvasively diagnose or rule out signifi cant epicardial CAD. Cardiac CT allows the 3-dimensional (3D) simultaneous imaging of additional cardiac structures-including the coronary veins, pulmonary veins, atria, ventricles, aorta, and thoracic arterial and venous structures-and defi nition of their spatial relationships for the comprehensive assessment of a variety of cardiovascular disease processes. This chapter details the role of cardiac CT for the assessment of cardiovascular pathology with an emphasis on the detection of coronary atherosclerosis.