Computed Tomography of Ovarian Carcinoma

Kalovidouris, A.; Gouliamos, A.; Pontifex, G; Gennatas, K; Dardoufas, K.; Papavasiliou, C.

doi:10.1177/028418518402500308

Cited by 16 publications

(2 citation statements)

References 14 publications

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“…Radiology plays an important role in the accurate staging of OC, and particularly in the accurate mapping of PC, helping to plan the appropriate therapeutic strategy (3,4). CT, MRI, and positron emission tomography (PET)/CT have been used to preoperatively assess the extent of the disease and tumor resectability, to predict the likelihood of optimal cytoreduction, to identify potentially unresectable or difficult disease areas that may require surgery modifications, to suggest the need for postoperative chemotherapy in cases of suboptimal debulking, and to evaluate tumor response to chemotherapy (1)(2)(3)(4)(5)(6)(7)(20)(21)(22)(23)(24). Currently, multidetector CT (MDCT) represents the examination of choice for initial staging of OC and for assessment of the extent of the disease in suspected recurrence (3,4).…”

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confidence: 99%

Multidetector computed tomography in diagnosing peritoneal metastases in ovarian carcinoma

2020

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Multidetector computed tomography (MDCT) of the abdomen is currently the imaging examination of choice for the staging and follow-up of ovarian carcinoma (OC). Peritoneal metastases (PMs) represent the most common pathway for the metastatic spread of OC. MDCT scanners, due to several advantages—including increased volume coverage, reduced scanning time, acquisition of thin slices and creation of multiplanar reformations, and three-dimensional reconstructions—provide useful information regarding the early and accurate detection of PMs. Detailed mapping of peritoneal carcinomatosis is feasible, with improved detection of sub-centimeter peritoneal implants and thorough evaluation of curved peritoneal surfaces.

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Section: Introductionmentioning

confidence: 99%

Multidetector computed tomography in diagnosing peritoneal metastases in ovarian carcinoma

2020

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“…All these methods have been used extensively and are widely reported in the literature, with CT and MRI have accuracies ranging from 60 to 90% for diagnosis and staging of ovarian malignancy. [3][4][5][6][7][8][9][10] The overall findings indicate that MRI is superior to Doppler ultrasound and CT in determining malignancy, but there appears to be no difference in the accuracy of CT and MRI in staging the disease. 11,12 MRI is cost-effective and reliable when the results of ultrasound evaluation are not clear.…”

Section: Introductionmentioning

confidence: 99%

The accurate staging of ovarian cancer using 3T magnetic resonance imaging – a realistic option

Booth

Turnbull

Poole

et al. 2008

BJOG

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Objectives The aim of the study was to determine whether staging primary ovarian cancer using 3.0 Tesla (3T) magnetic resonance imaging (MRI) is comparable to surgical staging of the disease.Design A retrospective study consisting of a search of the pathology database to identify women with ovarian pathology from May 2004 to January 2007.Setting All women treated for suspected ovarian cancer in our cancer centre region.Sample All women suspected of ovarian pathology who underwent 3T MRI prior to primary surgical intervention between May 2004 and January 2007.Methods All women found to have ovarian pathology, both benign and malignant, were then cross checked with the magnetic resonance (MR) database to identify those who had undergone 3T MRI prior to surgery. The resulting group of women underwent comparison of the MR, surgical and histopathological findings for each individual including diagnosis of benign or malignant disease and International Federation of Gynecology and Obstetrics (FIGO) staging where appropriate.Main outcome measures Comparisons were made between the staging accuracy of 3T MRI and surgical staging compared with histopathological findings and FIGO stage using weighted kappa. Sensitivity, specificity and accuracy were calculated for diagnosing malignant ovarian disease with 3T MRI.Results A total of 191 women identified as having ovarian pathology underwent imaging with 3T MR and primary surgical intervention. In 19 of these women, the ovarian disease was an incidental finding. The group for which staging methods were compared consisted of 77 women of primary ovarian malignancy (20 of whom had borderline tumours). 3T MRI was able to detect ovarian malignancy with a sensitivity of 92% and a specificity of 76%. The overall accuracy in detecting malignancy with 3T MRI was 84%, with a positive predictive value of 80% and negative predictive value of 90%. Statistical analysis of the two methods of staging using weighted kappa, gave a K value of 0.926 (SE ±0.121) for surgical staging and 0.866 (SE ±0.119) for MR staging. A further analysis of the staging data for ovarian cancers alone, excluding borderline tumours resulted in a K value of 0.931 (SE ±0.136) for histopathological staging versus MR staging and 0.958 (±0.140) for histopathological stage versus surgical staging.Conclusion Our study has shown that MRI can achieve staging of ovarian cancer comparable with the accuracy seen with surgical staging. No previous studies comparing different modalities have used the higher field strength 3T MRI. In addition, all other studies comparing radiological assessment of ovarian cancer have grouped the stages into I, II, III and IV rather than the more clinically appropriate a, b and c subgroups.Keywords 3.0T MRI, ovarian cancer, staging.Please cite this paper as: Booth S, Turnbull L, Poole D, Richmond I. The accurate staging of ovarian cancer using 3T magnetic resonance imaging -a realistic option. BJOG 2008;115:894-901.

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Imaging of ovarian cancer

Forstner¹,

Chen

Hricak

1995

Magnetic Resonance Imaging

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Cross sectional imaging continues to play an increasingly important role in ovarian cancer diagnosis, staging, and treatment follow-up. Screening for ovarian cancer remains a controversial subject. The combined use of clinical examination, CA-125, and endovaginal ultrasound (US) are being advocated for high risk patients but consensus recommendation for screening awaits further studies. In characterization of an ovarian neoplasm US is indisputedly the primary imaging approach. Only when US is inconclusive are further studies warranted. Magnetic resonance imaging (MRI) is generally preferred to computer tomography (CT). A prospective MRI-CT clinical trial has not been performed as yet. Preoperative staging by imaging is slowly gaining its acceptance. This is mostly due to the awareness of the difficulties and inaccuracy in surgical staging when unsuspected extensive disease is present. Furthermore, in known resectable ovarian cancer, primary chemotherapeutic cytoreduction may be a better treatment option. Accuracy of CT and MRI in staging ovarian cancer is similar, CT, however, is faster, more widely available, and less expensive; these are important attributes that are decisive in this time of health reimbursement constraints.

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Computed Tomography of Ovarian Carcinoma

Cited by 16 publications

References 14 publications

Multidetector computed tomography in diagnosing peritoneal metastases in ovarian carcinoma

Multidetector computed tomography in diagnosing peritoneal metastases in ovarian carcinoma

The accurate staging of ovarian cancer using 3T magnetic resonance imaging – a realistic option

Imaging of ovarian cancer

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