Measuring ‘outcome’ in rhinology has been challenging investigators for decades. With the introduction of patient-based, quality of life outcomes, investigators have developed rhinologic-specific outcomes tools for allergic rhinitis, nasal obstruction, and chronic rhinosinusitis. Outcomes research in rhinology, however, is a nascent field. This article focuses on outcomes research in the management of chronic rhinosinusitis, especially as it relates to endoscopic sinus surgery. Quality of life outcomes are addressed not only as outcomes but as measures of disease and how they relate to other commonly used measures of disease such as CT and endoscopy.