Computed tomography, ultrasound, and scintigraphy of the liver in patients with colon or breast carcinoma: a prospective comparison.

Alderson, Philip O.; Adams, D F; McNeil, Barbara J.; Sanders, R C; Siegelman, Stanley S.; Finberg, Harris J.; Hessel, Samuel J.; Hl, Abrams

doi:10.1148/radiology.149.1.6611929

Cited by 130 publications

(23 citation statements)

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“…These results are quite similar except for the higher sensitivity shown in this study . Most of the previous studies reported accuracy rate of 76 % -96 % which is quite comparable to the value of 96 % in this series (13)(14)(15) In evaluating lymph node involvement , Zaunbauer (11) reported an accuracy of 100 % ,…”

Section: Discussionsupporting

confidence: 83%

CT evaluation of colon carcinoma: Emphasis on distant lymph node invasion and liver metastases

Chung¹,

Cho²,

Lee³

et al. 1993

J Korean Radiol Soc

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-AbstractEven thou gh the value of computed tomography (CT) used to detect the colon carcinoma with minim al invasion is limited , its usefulness in the evaluation of the extent of disease such as hepatic metastasis or distant lymph node invasion has been emphasized. To examine the role of CT in the evaluation of colon carcinom a , CT scans obtained during the past 2 years in 56 patients with surgically proven colon carcinoma were reviewed and the findin gs correlated with pathologic results. The sensitivity and accuracy of CT for p er i c이 ic fat infiltration were 86 , 58 and 80% respectively. Those of regional node we re 60 , 83 and 75% and distant node 67 , 100 and 95 %. Liver metastases showed sensitivity, specificity and accuracy of 83 , 98 , 96% a nd peritoneal metastases 67 , 94 and 89% respectively.CT detected local invasion with fair d egree of accuracy but the true value of CT lie in the d etection of distant invasions such as liver and distant lymph node metastases thereby leading to preclusion of unnecessary procedures a nd implementation of appropria te procedures.

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Section: Discussionsupporting

confidence: 83%

CT evaluation of colon carcinoma: Emphasis on distant lymph node invasion and liver metastases

Chung¹,

Cho²,

Lee³

et al. 1993

J Korean Radiol Soc

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“…To this purpose, both tests proved to be highly specific [5,15,16]. In particular, the specificity of diagnosis of liver metastases 1 cm or more in size by ultrasonography has been reported to range from 71 to 100% [17][18][19]. Nevertheless, some imaging findings can be present which are subject to equivocal interpretation [16,20].…”

Section: Discussionmentioning

confidence: 99%

Utility of a Serum Tumour Marker Panel in the Post-Operative Follow-Up of Breast Cancer Patients with Equivocal Conventional Radiological Examinations

Nicolini¹,

Carpi²,

Pieri³

2003

Tumor Biol

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Objective: To assess the value of the serum carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and breast cancer-associated antigen CA15.3 (CEA-TPA-CA15.3) tumour marker panel in selecting from a group of patients with equivocal bone scintigraphy, chest X-ray or liver echography, those with skeletal, thoracic or liver metastases. Clinical data of 427 breast cancer patients submitted to an intensive follow-up after mastectomy between January 1986 and December 2000 were retrospectively reviewed. Methods: Among the 427 patients operated on for breast cancer, 221 patients with a total of 332 equivocal instrumental examinations (bone scintigraphy, n = 286; chest X-ray, n = 29; liver echography, n = 17) were reviewed. All 221 patients were followed up clinically, biochemically and instrumentally until there was a clear definition of their condition, metastatic or not, for an average time of 35 months. Positive and negative predictive values of the tumour marker panel in patients with equivocal bone scintigraphy, chest X-ray and liver echography were evaluated; concomitant clinical symptoms were also taken into consideration. Results: Among the 221 patients with equivocal bone scintigraphy, chest X-ray and liver echography, tumour markers showed a positive predictive value of 69, 93 and 83% and a negative predictive value of 98, 86 and 91%, respectively, for the indication of the metastatic or benign origin of the equivocal instrumental imaging. Clinical symptoms were not helpful in predicting metastatic disease (sensitivity, specificity and accuracy of 60, 53 and 54%, respectively). Conclusions: These data suggest that a short monitoring with the CEA-TPA-CA15.3 tumour marker panel is an important tool to confirm or exclude metastatic disease in those patients who are suspected to have metastases following common instrumental investigations, and it is particularly important to avoid false positive diagnoses.

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“…18 • 19 More recent studies, with faster total body scan times of 18 seconds and less roentgenogram diffraction by using narrower window widths, have shown CT to be equal, or superior, to US and RN scans in evaluating hepatic neoplasms. [7][8][9][10] Cancer patients receiving hepatic resection or transplantation are an ideal population in which to study the accuracy of hepatic-imaging techniques. The imaging procedure in this setting is usually done shortly before the operative procedure.…”

Section: Discussionmentioning

confidence: 99%

“…CT is presently considered to be the single best examination to determine both the presence and the extent of space-occupying lesions within the liver. [8][9][10] CT scanning. therefore, has become an accepted method for defining tumor response to treatment.…”

mentioning

confidence: 99%

Accuracy of computerized tomography in determining hepatic tumor size in patients receiving liver transplantation or resection.

Mittal¹,

Kowal²,

Starzl³

et al. 1984

JCO

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Computerized tomography (CT) of liver is used in oncologic practice for staging tumors, evaluating response to treatment, and screening patients for hepatic resection. Because of the impact of CT liver scan on major treatment decisions, it is important to assess its accuracy. Patients undergoing liver transplantation or resection provide a unique opportunity to test the accuracy of hepatic-imaging techniques by comparison of findings of preoperative CT scan with those at gross pathologic examination of resected specimens. Forty-one patients who had partial hepatic resection (34 patients) or liver transplantation (eight patients) for malignant (30 patients) or benign (11 patients) tumors were evaluable. Eight (47%) of 17 patients with primary malignant liver tumors, four (31%) of 13 patients with metastatic liver tumors, and two (20%) of 10 patients with benign liver tumors had tumor nodules in resected specimens that were not apparent on preoperative CT studies. These nodules varied in size from 0.1 to 1.6 cm. While 11 of 14 of these nodules were less than 1.0 cm, three of 14 were greater than 1.0 cm. These results suggest that conventional CT alone may be insufficient to accurately determine the presence or absence of liver metastases, extent of liver involvement, or response of hepatic metastases to treatment.

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Computed tomography, ultrasound, and scintigraphy of the liver in patients with colon or breast carcinoma: a prospective comparison.

Cited by 130 publications

References 0 publications

CT evaluation of colon carcinoma: Emphasis on distant lymph node invasion and liver metastases

CT evaluation of colon carcinoma: Emphasis on distant lymph node invasion and liver metastases

Utility of a Serum Tumour Marker Panel in the Post-Operative Follow-Up of Breast Cancer Patients with Equivocal Conventional Radiological Examinations

Accuracy of computerized tomography in determining hepatic tumor size in patients receiving liver transplantation or resection.

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