Computer Aided Design of Molecular Imprinted Polymer for Selective Recognition of Capsaicin

Tahir, Inayatullah; Wijaya, Karna; Islam, A.K.M. Shafiqul; Ahmad, Mardiana Idayu

doi:10.22146/ijc.21272

Cited by 2 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…where, Ci and Ce are initial and equilibrium concentrations (mmol/L), respectively, V is the volume of sample solution (L) and m is the mass of Sorbent (g) [25]. The adsorption data were fitted into Langmuir, Freundlich and Langmuir-Freundlich Isotherm models [26].…”

Section: Adsorption Isothermmentioning

confidence: 99%

A Novel Molecular Imprint Polymer Synthesis for Solid Phase Extraction of Andrographolide

et al. 2019

Self Cite

View full text Add to dashboard Cite

The use of molecularly imprinted polymers for Solid phase micro-extraction (SPME) of bioactive compounds are getting popularity. The interest on efficient extraction process of andrographolide from the plant is increasing due to their vast therapeutic applications. In this study, andrographolide imprinted MIP was prepared by precipitation polymerization method using the non-covalent technique to use as sorbent materials for solid phase extraction of the bioactive compound. HyperChem 8.0.10 software was used to investigate and optimize the template and functional monomer ratio in the pre-polymerization system to synthesize the imprinted polymers. Molecular modeling gives information about molecular interactions and the Gibbs free energies of the pre-polymerization complex. Based on the computational study, andrographolide, methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) were used as the template, functional monomer, and cross-linker, respectively at the 1:3:20 ratios. The MIPs were characterized by kinetic study and imprinting factor. The binding parameters for the recognition of andrographolide were studied using Langmuir, Freundlich and Langmuir-Freundlich adsorption isotherm models. Andrographolide MIP contains the maximum number of binding sites with the adsorption capacity of 149.59 μg/g. The SPME experimental data best fit with Langmuir-Freundlich isotherm model with the R2 value of 0.997. This research shows that the MIPs prepared by precipitation polymerization gives a good extraction capability using SPME method.

show abstract

Section: Adsorption Isothermmentioning

confidence: 99%

A Novel Molecular Imprint Polymer Synthesis for Solid Phase Extraction of Andrographolide

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Computational Design of Molecularly Imprinted Polymers in Drug Delivery Systems: A Comprehensive Review

Singh

Chawla

Faruk

et al. 2023

CDD

View full text Add to dashboard Cite

Background: Nowadays, biomedical research has been focusing on the design and development of new drug delivery systems that provide efficient drug targeting. The molecularly imprinted polymers (MIPs) have attracted wide interest and play an indispensable role as a drug carrier. Drug delivery systems based on MIPs have been frequently cited in the literature. They are cross-linked polymers that contain binding sites according to the complementary structure of the template molecules. They possess distinctive features of structure predictability and site recognition specificity. Versatile applications of MIPs include purification, biosensing, bioseparation, artificial antibodies, and drug delivery. An ideal MIPs should include features such as biocompatibility, biodegradability, and stability. Objective: In this article, we elaborate the historic growth, synthesis, and preparation of different MIPs and present an updated summary of recent advances in the development of new drug delivery system which are based on this technique. Their potential to deliver drugs in a controlled and targeted manner will also be discussed. Conclusion: MIPs possess unique advantages, such as lower toxicity, and fewer side effects, and good therapeutic potential. They offer administration of drugs by different routes, i.e., oral, ocular or transdermal. Despite several advantages, biomedical companies are hesitant to invest in MIPs based drug delivery system due to the limited availability of chemical compounds.

show abstract

Computer Aided Design of Molecular Imprinted Polymer for Selective Recognition of Capsaicin

Abstract: ABSTRACT

Cited by 2 publications

References 28 publications

A Novel Molecular Imprint Polymer Synthesis for Solid Phase Extraction of Andrographolide

A Novel Molecular Imprint Polymer Synthesis for Solid Phase Extraction of Andrographolide

Computational Design of Molecularly Imprinted Polymers in Drug Delivery Systems: A Comprehensive Review

Contact Info

Product

Resources

About