Computer-aided docking studies of phytochemicals from plants Salix subserrata and Onion as inhibitors of glycoprotein G of rabies virus

Dhorajiwala, Tehseen M; Halder, Sumit T; Samant, Lalit R.

doi:10.4103/bbrj.bbrj_124_19

Cited by 7 publications

(2 citation statements)

References 23 publications

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“…This property could be as a result of the onion. Again, studies have shown that onion phytochemicals show an anti-rabies activity mainly because of the presence of (+) catechins [ 45 ]. A kind of fructan was isolated from green onion as an anti-influenza virus substance ( Allium fistulosum L.).…”

Section: Discussionmentioning

confidence: 99%

The Activity of Plant-Derived Ren’s Oligopeptides-1 against the Pseudorabies Virus

Xiao

Cai

et al. 2022

Animals

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Newly synthesized Ren’s oligopeptides-1 was found to have an antiviral effect in clinical trials, and the purpose of this study was to further demonstrate the antiviral activity of Ren’s oligopeptides-1 against the PRV 152-GFP strain. We used the real-time cell analysis system (RTCA) to detect the cytotoxicity of different concentrations of Ren’s oligopeptides-1. We then applied high content screening (HCS) to detect the antiviral activity of Ren’s oligopeptides-1 against PRV. Meanwhile, the fluorescence signal of the virus was collected in real time and the expression levels of the related genes in the PK15 cells infected with PRV were detected using real-time PCR. At the mRNA level, we discovered that, at a concentration of 6 mg/mL, Ren’s oligopeptides-1 reduced the expression of pseudorabies virus (PRV) genes such as IE180, UL18, UL54, and UL21 at a concentration of 6 mg/mL. We then determined that Ren’s oligopeptides-1 has an EC50 value of 6 mg/mL, and at this level, no cytotoxicity was observed.

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Section: Discussionmentioning

confidence: 99%

The Activity of Plant-Derived Ren’s Oligopeptides-1 against the Pseudorabies Virus

Xiao

Cai

et al. 2022

Animals

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“…It is the online server based on the EADock DSS engine with the CHARMM22 force field that uses multiple scoring functions [7]. The 3D structure of the docked complex was visualized using the Pymol software [8]. The protein-ligand interaction profiler (PLIP) is an online server which is used for detecting and analyzing the non-covalent interaction between such as hydrogen bonds, salt bridges, hydrophobic and π-cation interactions between the ligand and the receptor.…”

Section: Molecular Docking Of Mkk4 With Kinase Inhibitorsmentioning

confidence: 99%

"Identification of Potential Kinase Inhibitors to Specifically Target Mkk4 for Skin Tumorigenesis"

Mohan

2023

BJSTR

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BJSTR. MS.ID.007627.MKK4, a Ser/Thr protein kinase, is one of the critical activators of MAP kinases in response to various mitogenic stimuli. MKK4 induces skin tumorigenesis through oncogenic activation of the ras gene. The MKK4 acts as the main component of JNK activation which directly induces the RAS signaling pathway. Overexpression of MKK4 is associated with the aggressiveness of various tumors including non-small cell lung, breast, prostate, stomach, and colon adenocarcinomas. Downstream signaling of MKK4 is important for the formation of tumors and hence acts as a potential drug target for cancer therapy. Interestingly, in the present study, it was found that Nilotinib and Dacomitinib bind to the catalytic pocket of MKK4 with the affinity of -9.47 and -9.00 kcal/mol respectively. It was observed that Nilotinib interacts with active site residues of MKK4 namely, Arg110, Lys187, Asp247, Ile108, and Leu236. In addition, it was also found that Dacomitinib interacts with active sites namely, Met181,

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Virtual screening, ADME prediction, drug-likeness, and molecular docking analysis of Fagonia indica chemical constituents against antidiabetic targets

Riaz,

Parveen,

Shafiq

et al. 2024

Mol Divers

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Computer-aided docking studies of phytochemicals from plants Salix subserrata and Onion as inhibitors of glycoprotein G of rabies virus

Cited by 7 publications

References 23 publications

The Activity of Plant-Derived Ren’s Oligopeptides-1 against the Pseudorabies Virus

The Activity of Plant-Derived Ren’s Oligopeptides-1 against the Pseudorabies Virus

"Identification of Potential Kinase Inhibitors to Specifically Target Mkk4 for Skin Tumorigenesis"

Virtual screening, ADME prediction, drug-likeness, and molecular docking analysis of Fagonia indica chemical constituents against antidiabetic targets

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