Computer-aided identification of protein targets of four polyphenols in Alzheimer's disease (AD) and validation in a mouse AD model

Li, Chaoyun; Meng, Ping; Zhang, Benzheng; Kang, Hong-Yo; Wen, Hanli; Schluesener, Hermann J.; Cao, Zhiwei; Zhang, Zhiyuan

doi:10.7555/jbr.32.20180021

Cited by 9 publications

(7 citation statements)

References 41 publications

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“…Polyphenol widely exists in plants rich in hydroxyl groups and can provide a great deal of reducing power to remove free radicals, including O 2– and singlet oxygen. It also is an important components for the stress tolerance of plants by preventing from oxidative damage …”

Section: Natural Antioxidants With Anti-ad Activitymentioning

confidence: 99%

Natural Antioxidants: An Effective Strategy for the Treatment of Alzheimer’s Disease at the Early Stage

Wang,

Huang,

et al. 2024

J. Agric. Food Chem.

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The critical role of oxidative stress in Alzheimer’s disease (AD) has been recognized by researchers recently, and natural antioxidants have been demonstrated to have anti-AD activity in animal models, such as Ginkgo biloba extract, soy isoflavones, lycopene, and so on. This paper summarized these natural antioxidants and points out that natural antioxidants always have multiple advantages which are help to deal with AD, such as clearing free radicals, regulating signal transduction, protecting mitochondrial function, and synaptic plasticity. Based on the available data, we have created a relatively complete pathway map of reactive oxygen species (ROS) and AD-related targets and concluded that oxidative stress caused by ROS is the core of AD pathogenesis. In the prospect, we introduced the concept of a combined therapeutic strategy, termed “Antioxidant-Promoting Synaptic Remodeling,” highlighting the integration of antioxidant interventions with synaptic remodeling approaches as a novel avenue for therapeutic exploration.

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Section: Natural Antioxidants With Anti-ad Activitymentioning

confidence: 99%

Natural Antioxidants: An Effective Strategy for the Treatment of Alzheimer’s Disease at the Early Stage

Wang,

Huang,

et al. 2024

J. Agric. Food Chem.

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“…Polyphenols are a sort of neuroprotective compound that consist of aromatic ring and one or more phenolic rings in natural plants [ 92 , 93 ]. Algae are rich in polyphenols (especially phloroglucinol, a kind of phlorotannins which has been proved to have many biological activities) [ 94 ].…”

Section: Anti-ad Marine Natural Productsmentioning

confidence: 99%

“…An experiment was conducted to investigate the effect of brown algae polyphenols on scopolamine-induced memory impairment in mice. The results showed that phlorotannins (50 or 100 mg/kg) orally supplemented for six weeks improved scopolamine-induced memory impairment in behavioral tests [ 93 ]. Phlorotannins decreased acetylcholinesterase activity in the brain, and significantly reduce lipid peroxidation levels but increased glutathione levels and superoxide dismutase activity [ 93 ].…”

Section: Anti-ad Marine Natural Productsmentioning

confidence: 99%

“…The results showed that phlorotannins (50 or 100 mg/kg) orally supplemented for six weeks improved scopolamine-induced memory impairment in behavioral tests [ 93 ]. Phlorotannins decreased acetylcholinesterase activity in the brain, and significantly reduce lipid peroxidation levels but increased glutathione levels and superoxide dismutase activity [ 93 ]. In addition, phlorotannins upregulate the expression levels of brain-derived neurotrophic factor (BDNF), phosphorylated extracellular signal-regulated kinase (ERK), and cyclic AMP-response element-binding protein (CREB), which influence cholinergic dysfunction and memory deficit [ 95 , 96 ].…”

Section: Anti-ad Marine Natural Productsmentioning

confidence: 99%

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Application of Marine Natural Products against Alzheimer’s Disease: Past, Present and Future

Jin

Hou

et al. 2023

Marine Drugs

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Alzheimer’s disease (AD), a neurodegenerative disease, is one of the most intractable illnesses which affects the elderly. Clinically manifested as various impairments in memory, language, cognition, visuospatial skills, executive function, etc., the symptoms gradually aggravated over time. The drugs currently used clinically can slow down the deterioration of AD and relieve symptoms but cannot completely cure them. The drugs are mainly acetylcholinesterase inhibitors (AChEI) and non-competitive N-methyl-D-aspartate receptor (NDMAR) antagonists. The pathogenesis of AD is inconclusive, but it is often associated with the expression of beta-amyloid. Abnormal deposition of amyloid and hyperphosphorylation of tau protein in the brain have been key targets for past, current, and future drug development for the disease. At present, researchers are paying more and more attention to excavate natural compounds which can be effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been demonstrated to be the most prospective candidates of these compounds, and some have presented significant neuroprotection functions. Consequently, we intend to describe the potential effect of bioactive compounds derived from marine organisms, including polysaccharides, carotenoids, polyphenols, sterols and alkaloids as drug candidates, to further discover novel and efficacious drug compounds which are effective against AD.

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“…The simplified DOCK scoring function is used to estimate the ligand-protein binding energy. INVDOCK has been used for reverse docking in many studies [87][88][89][90][91][92] and it has recently been employed to analyze potential protein targets of polyphenols, as well as to evaluate their effects on Alzheimer's disease [93].…”

Section: Reverse Dockingmentioning

confidence: 99%

Recent Advances in In Silico Target Fishing

et al. 2021

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In silico target fishing, whose aim is to identify possible protein targets for a query molecule, is an emerging approach used in drug discovery due its wide variety of applications. This strategy allows the clarification of mechanism of action and biological activities of compounds whose target is still unknown. Moreover, target fishing can be employed for the identification of off targets of drug candidates, thus recognizing and preventing their possible adverse effects. For these reasons, target fishing has increasingly become a key approach for polypharmacology, drug repurposing, and the identification of new drug targets. While experimental target fishing can be lengthy and difficult to implement, due to the plethora of interactions that may occur for a single small-molecule with different protein targets, an in silico approach can be quicker, less expensive, more efficient for specific protein structures, and thus easier to employ. Moreover, the possibility to use it in combination with docking and virtual screening studies, as well as the increasing number of web-based tools that have been recently developed, make target fishing a more appealing method for drug discovery. It is especially worth underlining the increasing implementation of machine learning in this field, both as a main target fishing approach and as a further development of already applied strategies. This review reports on the main in silico target fishing strategies, belonging to both ligand-based and receptor-based approaches, developed and applied in the last years, with a particular attention to the different web tools freely accessible by the scientific community for performing target fishing studies.

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Computer-aided identification of protein targets of four polyphenols in Alzheimer's disease (AD) and validation in a mouse AD model

Cited by 9 publications

References 41 publications

Natural Antioxidants: An Effective Strategy for the Treatment of Alzheimer’s Disease at the Early Stage

Natural Antioxidants: An Effective Strategy for the Treatment of Alzheimer’s Disease at the Early Stage

Application of Marine Natural Products against Alzheimer’s Disease: Past, Present and Future

Recent Advances in In Silico Target Fishing

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