Computer-assisted 3-D reconstructions of Golgi-impregnated neurons in the cortical regions of the inferior colliculus of rat

Malmierca, Manuel S.; Blackstad, Theodor W.; Osen, Kirsten K.

doi:10.1016/j.heares.2010.06.011

Cited by 56 publications

(57 citation statements)

References 84 publications

(90 reference statements)

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“…12-15), usually referred to as "fibrodendritic laminae" (cat: Morest, 1964a). This characteristic laminar organization of the CIC has been observed in all species studied (Morest, 1964a;Morest and Oliver, 1984;Oliver and Morest, 1984;Zook et al, 1985;Malmierca and Ryugo, 2012;Wallace et al, 2012) including rat (Faye-lund and Osen, 1985;Malmierca, 1991;Malmierca et al, 1993Malmierca et al, , 1995bLoftus et al, 2008), and it constitutes the structural basis for tonotopic organization (Fig. 3;Friauf, 1992;Pierson and Snyder-Keller, 1994;Malmierca et al, 2008).…”

Section: The Central Nucleusmentioning

confidence: 67%

“…In addition to small and medium-sized cells, layer 3 contains large multipolar cells especially ventromedially and rostrally. The border with the CIC is blurred ventrally and rostrally, while dorsolaterally it is indicated by a distinct shift in dendritic orientation, particularly conspicuous in transverse sections through the caudal IC (Faye-Lund and Osen, 1985;Malmierca, 1991), where three morphologically distinct neuron types (bitufted, pyramidal-like and chandelier; Fig. 19B-D) have been described (Malmierca, 1991;.…”

Section: The Lateral Cortexmentioning

confidence: 99%

“…29;Warr, 1992;Caicedo and Herbert, 1993;Saldaña, 1993;Vetter et al, 1993). In addition, the IC possesses well-developed commissural (Coleman and Clerici, 1987;Saldaña and Merchán, 1992;Malmierca et al, 1995aMalmierca et al, , 2003Malmierca et al, , 2005bMalmierca et al, , 2009a and intrinsic (Malmierca, 1991;González-Hernández et al, 1986;Saldaña and Merchán, 1992;Malmierca et al, 2009a) fiber systems (Fig. 23).…”

Section: The Inferior Colliculusmentioning

confidence: 99%

“…Three layers are defined in the LCIC (Faye-Lund and Osen, 1985;Malmierca, 1991;Loftus et al, 2008;. The deep lateral cortex is marked by a transition between the nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) rich superficial cortex and a cytochrome oxidase (CO) rich central nucleus (Loftus et al, 2008).…”

Section: The Lateral Cortexmentioning

confidence: 99%

“…The border with the CIC is blurred ventrally and rostrally, while dorsolaterally it is indicated by a distinct shift in dendritic orientation, particularly conspicuous in transverse sections through the caudal IC (Faye-Lund and Osen, 1985;Malmierca, 1991), where three morphologically distinct neuron types (bitufted, pyramidal-like and chandelier; Fig. 19B-D) have been described (Malmierca, 1991;. Computer-assisted 3-dimensional reconstructions of neurons in this region have demonstrated that their dendritic arbors are different from those of the F neurons in the CIC in several respects including their thickness and orientation .…”

Section: The Lateral Cortexmentioning

confidence: 99%

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Auditory System

Malmierca

2015

The Rat Nervous System

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Section: The Central Nucleusmentioning

confidence: 67%

Section: The Lateral Cortexmentioning

confidence: 99%

Section: The Inferior Colliculusmentioning

confidence: 99%

Section: The Lateral Cortexmentioning

confidence: 99%

Section: The Lateral Cortexmentioning

confidence: 99%

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Auditory System

Malmierca

2015

The Rat Nervous System

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Subcortical auditory structures in the mongolian gerbil: I. Golgi architecture

Mylius

Brosch

Scheich

et al. 2013

J of Comparative Neurology

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By means of the Golgi-Cox and Nissl methods we investigated the cyto- and fiberarchitecture as well as the morphology of neurons in the subcortical auditory structures of the Mongolian gerbil (Meriones unguiculatus), a frequently used animal model in auditory neuroscience. We describe the divisions and subdivisions of the auditory thalamus including the medial geniculate body, suprageniculate nucleus, and reticular thalamic nucleus, as well as of the inferior colliculi, nuclei of the lateral lemniscus, superior olivary complex, and cochlear nuclear complex. In this study, we 1) confirm previous results about the organization of the gerbil's subcortical auditory pathway using other anatomical staining methods (e.g., Budinger et al. [2000] Eur J Neurosci 12:2452-2474); 2) add substantially to the knowledge about the laminar and cellular organization of the gerbil's subcortical auditory structures, in particular about the orientation of their fibrodendritic laminae and about the morphology of their most distinctive neuron types; and 3) demonstrate that the cellular organization of these structures, as seen by the Golgi technique, corresponds generally to that of other mammalian species, in particular to that of rodents.

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Local and commissural IC neurons make axosomatic inputs on large GABAergic tectothalamic neurons

Ito

Oliver

2014

J of Comparative Neurology

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Large GABAergic (LG) neurons are a distinct type of neuron in the inferior colliculus (IC) identified by their dense VGLUT2-containing axosomatic synaptic terminals. Yet, the sources of these terminals are unknown. Since IC glutamatergic neurons express VGLUT2, and IC neurons are known to have local collaterals, we tested the hypothesis that these excitatory, glutamatergic axosomatic inputs on LG neurons come from local axonal collaterals and commissural IC neurons. We injected a recombinant viral tracer into the IC which enabled Golgi-like GFP labeling in both dendrites and axons. In all cases, we found terminals positive for both GFP and VGLUT2 (GFP+/VGLUT2+) that made axosomatic contacts on LG neurons. One to six axosomatic contacts were made on a single LG cell body by a single axonal branch. The GFP-labeled neurons giving rise to the VGLUT2+ terminals on LG neurons were close by. The density of GFP+/VGLUT2+ terminals on the LG neurons was related to the number of nearby GFP-labeled cells. On the contralateral side, a smaller number of LG neurons received axosomatic contacts from GFP+/VGLUT2+ terminals. In cases with a single GFP-labeled glutamatergic neuron, the labeled axonal plexus was flat, oriented in parallel to the fibrodendritic laminae, and contacted 9–30 LG cell bodies within the plexus. Our data demonstrated that within the IC microcircuitry, there is a convergence of inputs from local IC excitatory neurons on LG cell bodies. This suggests that LG neurons are heavily influenced by the activity of the nearby laminar glutamatergic neurons in the IC.

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Computer-assisted 3-D reconstructions of Golgi-impregnated neurons in the cortical regions of the inferior colliculus of rat

Cited by 56 publications

References 84 publications

Auditory System

Auditory System

Subcortical auditory structures in the mongolian gerbil: I. Golgi architecture

Local and commissural IC neurons make axosomatic inputs on large GABAergic tectothalamic neurons

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