Computer-assisted alignment and tracking of acne lesions indicate that most inflammatory lesions arise from comedones and de novo

Thy, Thy; Zarkhin, Semyon; Orringer, Jeffrey S.; S, Nemeth; Hamilton, Ted A.; Sachs, Dana L.; Voorhees, John J.; Kang, Sewon

doi:10.1016/j.jaad.2007.12.024

Cited by 56 publications

(44 citation statements)

References 26 publications

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“…Biopsy specimens from the normal-looking skin of acne patients that show no evidence of microcomedones or ductal hyperproliferation whatsoever have a significant inflammatory cell infiltrate around the follicle (particularly CD3+ and CD4+ cells and macrophages), which suggests that inflammatory events are involved in acne lesion initiation and may respond to antimicrobial agents [9]. These observations indicate that one effect of current topical prescription drugs may be the shortening of time-to-healing of ongoing lesions, a fact that has not, actually, been well demonstrated so far [10]. …”

Section: The Lifetime Of Acne Lesionsmentioning

confidence: 99%

Strategic Targets in Acne: The Comedone Switch in Question

Saurat¹

2015

Dermatology

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The sequence of events and mechanisms leading to the development of the primary acne lesion, the comedone, is revisited. Recent knowledge obtained both from lineage tracing experiments in the mouse and the pilosebaceous response to xenobiotics in humans provides robust models for further understanding key biological events at the cellular roots of comedogenesis. The focus is set on the LRIG1+ sebaceous stem cells in the isthmus of the pilosebaceous duct. The master switch that transforms a normally functioning sebaceous gland into a microcomedone and the hierarchy of factors involved in this process are reviewed. The key strategic target in acne care appears to be the naïve pilosebaceous follicle that is not involved yet in the acne cycle. The prevention of the comedone switch implies that the key switching factors are adequately controlled in the long term.

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Section: The Lifetime Of Acne Lesionsmentioning

confidence: 99%

Strategic Targets in Acne: The Comedone Switch in Question

Saurat¹

2015

Dermatology

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“…The anchor between the distal arrector pili and the extracellular matrix includes both α5β1 integrin and fibronectin. 49 However, quite a few cases (28%) appear to arise from normal skin, although some microcomedones may be difficult to visualize. 24 In a small proportion, it produces considerable disfigurement.…”

Section: The Normal Hair Folliclementioning

confidence: 99%

“…12,13 Attention has turned recently to the hair follicle immune system and its possible role in the causation of alopecia areata and the follicu-mild affliction which improves spontaneously after adolescence. 49 Acne affects the face and, less frequently, the upper part of the trunk. Severity can impact on the quality of life of the affected individual.…”

Section: The Normal Hair Folliclementioning

confidence: 99%

Diseases of cutaneous appendages

Weedon

2010

Weedon's Skin Pathology

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“…A high incidence of acne is found in girls aged 14-17 and in boys aged [16][17][18][19] [2]. The pathogenesis of acne is regulated by sebum hypersecretion in deformed follicles, which leads to microcomedones, and the follicular hyperproliferation of microcomedones causes inflammation [3], and comedones [4] in both open and closed types (black and white comedones) appearing in papules, pustules, nodules and cysts [5]. The resulting skin condition with sebum enrichment is prone to the anaerobic growth of Propionibacterium acnes, which is the main causative microorganism in acne.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic agents and herbs in topical application for acne treatment

Kanlayavattanakul

Lourith

2011

Intern J of Cosmetic Sci

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SynopsisAcne vulgaris suppresses an individual's self-confidence by causing distress with regard to physical appearance, which affects a significant number of individuals during puberty and is delineated by adolescence. Several treatments have been introduced to decrease the aesthetic and psychological problems caused by acne. The topical application of therapeutic agents has been found to be more feasible than hormonal treatment and laser therapy. The ingredients in topical acne treatments, particularly herbs and naturally derived compounds, have received considerable interest as they have fewer adverse effects than synthetic agents. Ré suméL'acné vulgaire touche à l'assurance d'un individu en causant une détresse face à son apparence physique. Elle affecte un nombre important d'individus pendant la puberté et est associée à l'adolescence. Plusieurs traitements ont été proposés pour diminuer les problèmes esthétiques et psychologiques causés par l'acné. L'application topique d'agents thérapeutiques a été estimée plus aisée qu'un traitement hormonal et une thérapie laser. Les ingrédients des traitements topiques de l'acné, particulièrement les plantes et les composés naturels dérivés ont suscité un intérêt considérable par leurs moindres effets indésirables que les ingrédients synthé-tiques.

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Computer-assisted alignment and tracking of acne lesions indicate that most inflammatory lesions arise from comedones and de novo

Cited by 56 publications

References 26 publications

Strategic Targets in Acne: The Comedone Switch in Question

Strategic Targets in Acne: The Comedone Switch in Question

Diseases of cutaneous appendages

Therapeutic agents and herbs in topical application for acne treatment

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