Computer-Based Cognitive Training for Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors

Bail, Jennifer R.; Meneses, Karen

doi:10.1188/16.cjon.504-509

Cited by 13 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the same time, there are many adverse reactions, which brings great pain to patients [ 3 ]. Studies have shown that chemotherapy will cause not only leukocytosis, nausea, vomiting, loss of appetite, bone marrow suppression, hair loss, and so on, but also severe cognitive decline [ 4 ]. Chemotherapy-related cognitive impairment [ 5 ] (chemotherapy-related cognitive impairment, CRCI), also known as chemotherapy brain (chemobrain) or chemotherapy fog (chemofog), is refered to the memory of patients with malignant tumors during or after chemotherapy and the decline of cognitive functions such as power, executive ability, language ability, reasoning ability, and visual space ability [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Changes and Influencing Factors of Cognitive Impairment in Patients with Breast Cancer

Cui

Shi

Song

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. To investigate the changes in cognitive function and its influencing factors in patients with breast cancer after chemotherapy, to provide a scientific basis for further cognitive correction therapy. Methods. In this study, general information on age, marital status, and chemotherapy regimen was collected from 172 breast cancer chemotherapy patients. 172 patients with breast cancer undergoing chemotherapy were investigated by convenience sampling method, and the subjects were tested one-on-one using the Chinese version of the MATRICS Consensus Cognitive Battery (MCCB) computer system. Results. The mean value of standardized t-value of cognitive function and its abnormal dimensions in breast cancer patients undergoing chemotherapy were MCCB total cognition (66.3%, 36.99 ± 13.06, abnormal), working memory (73.3%, 36.84 ± 10.25), attention and alertness (70.3%, 37.20 ± 12.50), social cognition (65.1%, 39.54 ± 10.17), and visual memory (61.6%, 42.19 ± 9.38). A comparison of cognitive function among breast cancer chemotherapy patients with different demographic characteristics showed that differences in place of residence, educational level, monthly income, timing of chemotherapy, chemotherapy regimen, and chemotherapy times may be associated with abnormal cognitive function. Further multiple linear regression analysis was performed and the results showed that there was a linear regression between literacy, number of chemotherapy sessions, monthly personal income, and cognitive function. Conclusion. Cognitive impairment is common in patients with breast cancer after chemotherapy. Nurses should pay attention to the cognitive function changes and intervention of patients with breast cancer after chemotherapy, to prevent the changes of cognitive function and promote the rehabilitation of patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Changes and Influencing Factors of Cognitive Impairment in Patients with Breast Cancer

Cui

Shi

Song

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Accumulating data from the ACTIVE Study indicate that cognitive training, specifically SOP training, helps older adults to age better cognitively, even 10 years after receipt of training [ 7 ]. Since this intervention works well in older adults [ 8 ], such targeted cognitive training may be of value for older breast cancer survivors (BCS) [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Breast cancer survivors (BCS) have a high incidence of impairment on neurocognitive tests of SOP [ 10 , 11 ]. Even subtle SOP deficits can disrupt other cognitive domains such as memory and attention, thus impeding everyday functioning at work and home [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Speed of processing training in middle-aged and older breast cancer survivors (SOAR): results of a randomized controlled pilot

Meneses

Benz

Bail

et al. 2017

Breast Cancer Res Treat

Self Cite

View full text Add to dashboard Cite

PurposeCognitive changes are common among breast cancer survivors. There is limited evidence to guide management of cognitive changes. This randomized controlled pilot evaluated the preliminary efficacy of a speed of processing (SOP) training among middle-aged and older breast cancer survivors.MethodsSixty breast cancer survivors with self-reported cognitive changes were recruited to the SOAR study. Participants were randomized to either a home-based SOP training (n = 30) or no-contact control group (n = 30). Primary outcomes were SOP (Useful Field of View Test®), and executive function (NIH Toolbox Cognition Battery). Neuropsychological assessments were completed at baseline, 6 weeks, and 6 months post study entry. Data were analyzed using repeated measures t tests, analysis of covariance, and sensitivity analyses.ResultsSOP training resulted in improvement in objective measures of SOP and executive function. Immediate (6 week) posttest and 6-month follow-up demonstrated large SOP training effects over time. Large representation of African American women (51.2%) and 96% retention in the SOAR study add to study strengths.ConclusionHome-based SOP training shows promise for remediating cognitive changes following breast cancer treatment, particularly improved SOP, and executive function.

show abstract

“…However, a relationship has been observed between emotional well-being (anxiety and depression) and the severity of cognitive alterations in these patients. Therefore, a transdiagnostic intervention can be useful to improve their emotional state and cognitive performance [8][9][10][11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

“…Several types of interventions, from pharmacological treatment to physical activity, have been developed to reduce cognitive impairment in cancer patients [3]. Among psychological interventions, cognitive behavioral therapy and cognitive training have shown positive results, although studies on these interventions have been carried out with limited samples of patients or without a control group [8][9][10][11][12]. However, since both anxiety and depression are related to cognitive impairment in cancer patients, a transdiagnostic intervention such as the Unified Protocol (UP) may be effective in reducing the presence of symptoms of cognitive impairment in these patients [13][14][15][16].…”

Section: Background and Rationale {6a}mentioning

confidence: 99%

Effectiveness of the Unified Barlow Protocol (UP) and neuropsychological treatment in cancer survivors for cognitive impairments: study protocol for a randomized controlled trial

García-Torres

Tejero-Perea

Gómez-Solís

et al. 2022

Trials

View full text Add to dashboard Cite

Background Cancer survivors frequently develop cognitive impairment, which negatively affects their quality of life and emotional well-being. This study compares the effectiveness of a well-established treatment (neuropsychological treatment) with the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) to reduce these cognitive deficits and evaluate the effect of both treatments on anxiety-depressive symptoms and the quality of life of cancer survivors. Methods A three-arm, randomized superiority clinical trial with a pre-post and repeated follow-up measures intergroup design using a 1:1:1 allocation ratio will be performed. One hundred and twenty-three cancer survivors with mild to moderate cognitive impairment will be randomly assigned to one of the study interventions: a cognitive rehabilitation intervention group, an intervention group with UP intervention, or a control group on the waiting list. The primary outcome is to observe a significant improvement in cognitive function in both intervention groups and a significant decrease in emotional impairments in comparison with the waitlist group. Improvements in anxiety, depression, and quality of life are also expected as secondary outcomes. These results will be maintained at 6 months of follow-up. Discussion The aim of this trial is to test the efficacy of the UP intervention in reducing cognitive deficits in breast cancer survivors. The results of this trial may be useful in reducing the presence of cognitive problems in cancer survivors and improving their emotional state and quality of life. Trial registration ClinicalTrials.gov NCT05289258. Registered 12 March 2022, v01.

show abstract

Computer-Based Cognitive Training for Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors

Cited by 13 publications

References 40 publications

Changes and Influencing Factors of Cognitive Impairment in Patients with Breast Cancer

Changes and Influencing Factors of Cognitive Impairment in Patients with Breast Cancer

Speed of processing training in middle-aged and older breast cancer survivors (SOAR): results of a randomized controlled pilot

Effectiveness of the Unified Barlow Protocol (UP) and neuropsychological treatment in cancer survivors for cognitive impairments: study protocol for a randomized controlled trial

Contact Info

Product

Resources

About