Computer-Based Quantitative Analysis of Gallium-67 Uptake in Normal and Diseased Lungs

Bisson, Guy; Drapeau, Guy; Lamoureux, Guy; Cantin, André M.; Rola‐Pleszczynski, Marek; Bégin, Raymond

doi:10.1378/chest.84.5.513

Cited by 56 publications

(18 citation statements)

References 9 publications

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“…Digital analysis was then performed using a variation of the method described by Bisson et al (1983) and Rom et al (1987). First, the posterior gallium chest view was displayed and the diaphragm marked.…”

Section: Patientsmentioning

confidence: 99%

“…It has been shown that gallium is delivered to the site of acute inflammation bound to transferrin (Tsan 1985;Klech et al 1987) and remains there by becoming associated with neutrophils, bacteria or various proteins (Tsan 1985). In the pneumoconioses, there is evidence to support the association of gallium uptake by the lungs with macrophages (Bisson et al 1983(Bisson et al , 1987Begin et al 1986;Rom et al 1987), neutrophils (Bisson et al 1987) and, to a lesser extent, lymphocytes (Bisson et al 1987), while in idiopathic pulmonary fibrosis, abnormal gallium uptake has been reported to be associated with neutrophils Klech et al 1987;Bertorelli et al 1988;Gibson et al 1989) and macrophages Vergnon et al 1987). Studies looking at the mechanisms responsible for gallium uptake, however, have tended to include few patients with diffuse lung disease associated with connective tissue diseases, a condition which may have a different aetiology and perhaps therefore a different pathophysiology compared with other forms of interstitial lung disease.…”

Section: Introductionmentioning

confidence: 97%

“…To our knowledge, however, no large prospective studies looking at pulmonary gallium uptake and bronchoalveolar lavage in patients with non-infective bronchiolitis have been reported. Smoking has also been a complicating factor in most studies and has been reported to increase pulmonary gallium uptake (Bisson et al 1983(Bisson et al , 1987Rom et al 1987;Sfakianikas et al 1988).…”

Section: Introductionmentioning

confidence: 99%

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Quantitative pulmonary gallium scanning in interstitial lung disease

et al. 1992

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The mechanisms responsible for gallium uptake in chronic, non-infective, diffuse lung disease are not completely understood. This study attempted to clarify some of them. A lung/liver gallium index was calculated in 113 subjects, some normal and some with various interstitial lung diseases, predominantly those associated with connective tissue disease. The mean gallium index was significantly higher in the groups with active interstitial lung disease (5.7) and non-infective bronchiolitis (4.1) compared with non-smoking normals (3.0; P less than 0.05). To investigate the mechanisms responsible for gallium uptake, the gallium index was correlated with bronchoalveolar lavage findings, respiratory function tests and clinical features. Significant correlations (P less than 0.05) were found with age in non-smoking normals; lavage macrophages in smoking normals; age but no other parameter in bronchiolitis; lavage lymphocytes, lavage albumin and improvement in diffusion capacity for carbon monoxide in those with active interstitial lung disease. It is concluded that in normal smokers gallium uptake may be due to a macrophage-mediated process. Gallium uptake in active interstitial lung disease associated with connective tissue disease appears to be an immunological process in which transport and retention of gallium is associated with that of albumin.

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Section: Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Quantitative pulmonary gallium scanning in interstitial lung disease

et al. 1992

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“…The validity of this method of deriving and index of Gallium uptake was examined by Begin et al in a· sheep model of asbestosis (88)(89)(90)(91).…”

Section: Jjmentioning

confidence: 99%

The Relationship between Respiratory Impairment and Asbestos-related Pleural Abnormality in an Active Work Force

Bourbeau

Ernst²,

Chrome³

et al. 1990

Am Rev Respir Dis

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“…In normal subjects over 40 years old, there is no significant difference in 67Ga uptake between smokers and nonsmokers, but in those younger than 40 years, 67Ga uptake is significantly higher among smokers (Bisson et al 1983). All asbestos-exposed subjects in this study and the majority of controls were more than 40 years old; therefore, smoking is unlikely to have significantly influenced the GI results.…”

Section: Discussionmentioning

confidence: 92%

Computer quantitation of gallium 67 lung uptake in crocidolite (blue asbestos) workers of Western Australia

et al. 1990

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Pulmonary inflammation has been evaluated in 43 crocidolite-exposed asbestos (ASB) workers and 12 control subjects, using a quantitative index of gallium uptake (GI). The GI was compared with chest roentgenographs (CXRs) graded by the ILO classification. The ASB workers included 15 with asbestosis (CXR greater than or equal to 1/0), 19 with a normal CXR (CXR 0/0), and 9 with equivocal CXR changes (CXR 0/1). In individuals with asbestosis the GI was 3.6 +/- 0.3 (mean +/- SEM), P less than 0.01 compared with exposed patients without asbestosis. In exposed patients with equivocal CXR changes (0/1) the GI was 3.1 +/- 0.3, and in exposed patients with a normal CXR (0/0) the GI was 2.4 +/- 0.2. The GI for subjects without lung disease was 1.2 +/- 0.2, P less than 0.01 compared with exposed patients without asbestosis. The scans were scored independently by two observers, and the correlation coefficient of the two sets of GI was 0.95. These data demonstrate that subjects with crocidolite-induced asbestosis and exposed patients with equivocal CXR changes or a normal CXR have significantly increased GI.

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Computer-Based Quantitative Analysis of Gallium-67 Uptake in Normal and Diseased Lungs

Cited by 56 publications

References 9 publications

Quantitative pulmonary gallium scanning in interstitial lung disease

Quantitative pulmonary gallium scanning in interstitial lung disease

The Relationship between Respiratory Impairment and Asbestos-related Pleural Abnormality in an Active Work Force

Computer quantitation of gallium 67 lung uptake in crocidolite (blue asbestos) workers of Western Australia

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