Computer‐based virtual reality assessment of functional capacity in primary psychosis

Ventura, Joseph

doi:10.1002/wps.21024

Cited by 12 publications

(8 citation statements)

References 10 publications

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“…In spite of the repeatedly demonstrated relationship of these variables with functional outcome, we did not find gender related differences in rates of clinical remission and recovery. A possible explanation of this finding may be the fact that recovery is a complex construct (Heckers and Kendler, 2020) which is influenced by several factors, among which negative symptoms, social and non-social cognition, functional capacity and personal resources, acting in a complex relationship as predictors or mediators of outcome (Green et al, 2000;Leifker et al, 2009;Harvey and Strassnig, 2012;Galderisi et al, 2014;Rossi et al, 2017;Galderisi et al, 2018b;Galderisi et al, 2020;Lahey et al, 2021;Ventura, 2022). Among the above-listed factors, some were more severe in men in our sample, while others were not.…”

Section: Tablementioning

confidence: 61%

Sex and gender differences in clinical and functional indices in subjects with schizophrenia and healthy controls: Data from the baseline and 4-year follow-up studies of the Italian Network for Research on Psychoses

Bucci,

Giordano,

Mucci

et al. 2023

Schizophrenia Research

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Section: Tablementioning

confidence: 61%

Sex and gender differences in clinical and functional indices in subjects with schizophrenia and healthy controls: Data from the baseline and 4-year follow-up studies of the Italian Network for Research on Psychoses

Bucci,

Giordano,

Mucci

et al. 2023

Schizophrenia Research

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“…According to some studies, social cognition is even more strongly associated to functional outcome than neurocognition; it is associated to work skills and interpersonal relationships directly ( 4 , 9 ) and with everyday life skills through functional capacity ( 5 , 62 ). According to other studies, it acts as a mediator between the latter and functional outcome ( 4 – 6 , 15 , 45 – 47 , 59 , 63 – 67 ), and between specific neurocognitive domains, such as processing speed ( 65 ), sustained attention ( 65 ) and verbal memory ( 64 ) and functional outcome.…”

Section: Introductionmentioning

confidence: 99%

Negative symptoms and social cognition as mediators of the relationship between neurocognition and functional outcome in schizophrenia

Giordano,

Pezzella,

Mucci

et al. 2024

Front. Psychiatry

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IntroductionIn this study we assessed the contribution of psychopathology, including the two domains of negative symptoms (motivational deficit and expressive deficit), processing speed as an index of neurocognition, and emotion recognition, as an index of social cognition, to poor functional outcomes in people with schizophrenia.MethodsThe Positive and Negative Syndrome Scale was used to evaluate positive symptoms and disorganization and the Brief Negative Symptom Scale to assess negative symptoms. The Symbol Coding and the Trail Making Test A and B were used to rate processing speed and the Facial Emotion Identification Test to assess emotion recognition. Functional outcome was assessed with the Personal and Social Performance Scale (PSP). Regression analyses were performed to identify predictors of functional outcome. Mediation analyses was used to investigate whether social cognition and negative symptom domains fully or partially mediated the impact of processing speed on functional outcome.ResultsOne hundred and fifty subjects from 8 different European centers were recruited. Our data showed that the expressive deficit predicted global functioning and together with motivational deficit fully mediated the effects of neurocognition on it. Motivational deficit was a predictor of personal and social functioning and fully mediated neurocognitive impairment effects on the same outcome. Both motivational deficit and neurocognitive impairment predicted socially useful activities, and the emotion recognition domain of social cognition partially mediated the impact of neurocognitive deficits on this outcome.ConclusionsOur results indicate that pathways to functional outcomes are specific for different domains of real-life functioning and that negative symptoms and social cognition mediate the impact of neurocognitive deficits on different domains of functioning. Our results suggest that both negative symptoms and social cognition should be targeted by psychosocial interventions to enhance the functional impact of neurocognitive remediation.

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“…For both of these disorders, psychoeducational family interventions (PFIs) have been shown to be particularly effective [ 21 , 22 , 23 ]. In fact, when provided to patients with schizophrenia and their family members, PFIs reduce relapses [ 24 ] and hospitalizations [ 25 , 26 , 27 , 28 ], and when provided to patients with bipolar disorder and their relatives, both during the acute phase [ 29 ] and in the long term [ 30 , 31 ], PFIs prevent relapses, reduce the number of acute episodes [ 32 ], improve patients’ adherence to pharmacological treatments [ 33 , 34 ], and foster psychosocial functioning [ 35 ] as well as coping strategies in their family members [ 36 , 37 , 38 , 39 , 40 ]. Based on this evidence, several international guidelines [ 41 , 42 , 43 , 44 ] recommend the use of PFIs in the clinical management of severe mental disorders, as well as the adoption of new delivery approaches which include modern technologies [ 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Psychoeducational Family Intervention for Major Depression: Study Protocol of a Randomized Controlled Trial

Toni,

Luciano,

Arsenio

et al. 2023

Brain Sciences

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This study aims to assess the efficacy of a psychoeducational family intervention (PFI) to reduce the severity of depressive symptoms and to improve psychosocial functioning and to increase social contacts in a sample of patients with major depressive disorder (MDD). The degree to which PFI will reduce patients’ relapses, hospitalizations, and self-stigmatization and will improve their quality of life will also be assessed. Other secondary outcomes include the improvement of relatives’ coping strategies, family burden, expressed emotions and quality of life. This non-profit, unfunded, national, multicentric randomized controlled trial with blinded outcome assessments will be carried out in 24 Italian university outpatient units. Families will be assessed at baseline and at 6, 12, and 24 months post-randomization. Our working hypothesis is that the PFIs will reduce the patients’ severity of depressive symptoms, their relapses, and their hospitalizations, and that they will improve their psychosocial functioning and quality of life. We expect these results to be maintained after 12 and 24 months, albeit with a reduction in magnitude. The sample will consist of 384 patients randomized at a 1:1 ratio and stratified according to center, age, gender, and educational level.

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Computer‐based virtual reality assessment of functional capacity in primary psychosis

Cited by 12 publications

References 10 publications

Sex and gender differences in clinical and functional indices in subjects with schizophrenia and healthy controls: Data from the baseline and 4-year follow-up studies of the Italian Network for Research on Psychoses

Sex and gender differences in clinical and functional indices in subjects with schizophrenia and healthy controls: Data from the baseline and 4-year follow-up studies of the Italian Network for Research on Psychoses

Negative symptoms and social cognition as mediators of the relationship between neurocognition and functional outcome in schizophrenia

The Efficacy of Psychoeducational Family Intervention for Major Depression: Study Protocol of a Randomized Controlled Trial

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