“…The finding that computerized data reduction yields superior precision to what is obtained via alternatives involving manual and/or mechanical processing is fairly typical of reports in this field (25)(26)(27). The one example referred to under item (c), where a significant deviation in the mean peak area is found, involves manual triangulation of the chlorpheniramine free base-lidocaine pair.…”
Four years ago, an agency decision was made to investigate the applicability of the on-line minicomputer in Food and Drug Administration district laboratories. Although several -
“…The finding that computerized data reduction yields superior precision to what is obtained via alternatives involving manual and/or mechanical processing is fairly typical of reports in this field (25)(26)(27). The one example referred to under item (c), where a significant deviation in the mean peak area is found, involves manual triangulation of the chlorpheniramine free base-lidocaine pair.…”
Four years ago, an agency decision was made to investigate the applicability of the on-line minicomputer in Food and Drug Administration district laboratories. Although several -
“…resoundingly self-evident (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Its role in research (2-7), in analytical service laboratories (8)(9)(10)(11)(12), in biomedical applications (13)(14)(15)(16), and in teaching (17)(18)(19)(20) is an increasingly important one.…”
“…Examples include the pen damping control on a strip chart recorder and the pH dependence of a reaction. Recent advances in computer-controlled instrumentation, as well as research on the automated development of analytical chemical methods (1)(2)(3)(4)(5)(6)(7)(8)(9)(10), have suggested a need for an efficient one-dimensional optimization strategy that can be easily automated and converges in the presence of error (11)(12)(13)(14)(15).…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.