At present, software products for numerical simulation of fluid dynamics problems (ANSYS Fluent, Ansys CFX, Star CCM, Comsol, etc.) problems are widely used. These software products are mainly based on the numerical solution of the Navier–Stokes equations, the most common and computationally easy method of solving, which is Reynolds averaging (RANS), and further closing the system using semi-empirical turbulence models. Currently, there are many modeling methods and turbulence models; however, there are no generalized recommendations for setting up grid models for modeling flows, while for practical use both the correct mathematical models and the setting of the computational grid are important. In particular, there are no generalized recommendations on the choice of scale of global elements of grid models for typical single channels. This work is devoted to the development and study of relations for a priori estimation of the parameters of a grid model in relation to solving hydrodynamic problems with fluid flow in channels. The paper proposes the introduction of a generalized grid convergence criterion for single channels at high Reynolds numbers. As single channels, a channel with a sudden expansion, a channel with a sudden contraction, and diffuser channels with different opening angles are considered. Based on the results of variant calculations of typical single channels at various Reynolds numbers and various geometric parameters, generalized criterion correlations were obtained to find dimensionless linear scales of grid elements relative to the hydrodynamic characteristics of the flow in the channel. Variant calculations of the compound channel were investigated, which showed the adequacy of correlations proposed.