The results of three years of research (2021-2023) are presented to study the effectiveness of pre-sowing treatment of seeds of grain crops (spring wheat, spring barley and oats) to regulate growth and development, increase yields and improve product quality. The research was carried out on leached chernozem of the Novosibirsk Ob region (JSC Irmen breeding plant, Ordynsky district, Novosibirsk region) and on gray forest soil (TPP “Michurintsev Garden”). The varieties of grain crops (spring wheat Licamero, spring barley Paustian and oats – Max) were studied. An increase in leaf area parameters was established against the background of the use of preparations for treating seeds with subsequent spraying of plants in the tillering phase with the following growth regulators Siliplant 0.01% (based on chelate forms), Epin-Extra 0.005%, Zircon 0.005%, Toro Combi 0.02% solution and Turmax 0.025% (chelate forms of macro and microelements). It was shown that the use of growth regulators increased the rate of growth and development, productivity and product quality. It was statistically established that the yield of grain crops depended on the elements - 38%, the crop under study - 31%, growth regulators and year conditions by 24%.