1984
DOI: 10.1002/bit.260260303
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Computer model for glucose‐limited growth of a single cell of Escherichia coli B/r‐A

Abstract: A computer model is described which is capable of predicting changes in cell composition, cell size, cell shape, and the timing of chromosome synthesis in response to changes in external glucose limitation. The model is constructed primarily from information on unrestricted growth in glucose minimal medium. The ability of the model to make reasonable quantitative predictions under glucose-limitation is a test of the plausibility of the basic biochemical mechanisms included in the model. Such a model should be … Show more

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Cited by 159 publications
(68 citation statements)
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“…Integration of this information to create quantitative, high-resolution, system-scale models has begun more recently and reflects the necessity of having sufficient information before construction of constrained models. Examples include models for the growth of a single bacterial cell (1,2), the regulation of genetic circuits (3,4) and the cell cycle (5,6), signal transduction (7)(8)(9), and metabolic pathways (10). A numerical model of a biological system is a complex hypothesis that can be used to compute the behavior of the system it represents (11).…”
mentioning
confidence: 99%
“…Integration of this information to create quantitative, high-resolution, system-scale models has begun more recently and reflects the necessity of having sufficient information before construction of constrained models. Examples include models for the growth of a single bacterial cell (1,2), the regulation of genetic circuits (3,4) and the cell cycle (5,6), signal transduction (7)(8)(9), and metabolic pathways (10). A numerical model of a biological system is a complex hypothesis that can be used to compute the behavior of the system it represents (11).…”
mentioning
confidence: 99%
“…It should be noted that although EFMs are defined on the basis of a steady-state analysis of the underlying reaction network, the resulting cybernetic model is fully dynamic and draws upon elementary mode analysis only to decompose the metabolic network into functional pathways. 45 and Chassagnole et al 46 to model E. coli metabolism and that of Rizzi et al 47 to model yeast. Unlike cybernetic models, these models attempt to account for regulation mechanistically by expanding the set of state variables to include known regulatory components and augmenting the kinetic rate expressions to include known regulatory interactions.…”
Section: Modelsmentioning
confidence: 98%
“…Shuler et al [187,188] developed large-scale computer models for the growth of a single cell. Other structured cell models, developed by Perretti and Bailey [189,190], take into account the perturbation of the metabolism that occurs as a result of the introduction of recombinant plasmids.…”
Section: Mathematical Modelsmentioning
confidence: 99%