Computer modeling of interaction between the antiviral drug riamilovir and HSP90

The aim of this study was to asses hepatoxicity of riamilovir with repeated administration on the animal model. Materials and methods. Twenty non-linear guinea pigs were randomized into 4 groups: control and three experimental, receiving 64 days of daily riamilovir orally in doses of 48, 96, 144 mg/kg. Biochemical profile: ALT, AST, GGT, total protein, total and direct bilirubins, albumin, cholesterol, triglycerides: on 0, 33 and 65 days from the start of the experiment. Results. A significant decrease of serum albumin and cholesterol levels was found only in group 2 and there were no statistically significant changes of other indicators. Conclusion. The data obtained indicate afunctional liver synthetic function changes without signs of hepatobiliary and hepatocellular damage.

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Assessment of Hepatotoxicity of Multiple Antiviral Riamilovir Preparation Administration in Non-Linear Guinea Pigs Model

Fedulova

Izmozherova

Petrov

et al. 2021

Journal of Volgograd State Medical University

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Computer modeling of interaction between the antiviral drug riamilovir and HSP90

Cited by 1 publication

References 6 publications

Assessment of Hepatotoxicity of Multiple Antiviral Riamilovir Preparation Administration in Non-Linear Guinea Pigs Model

Assessment of Hepatotoxicity of Multiple Antiviral Riamilovir Preparation Administration in Non-Linear Guinea Pigs Model

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