Computer modeling of the degradation behavior of polyester-based tissue engineering scaffolds

Samami, Hassan

doi:10.1016/b978-1-78242-087-3.00003-1

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Blending these materials in different proportions produces scaffolds with degradation varying from weeks to years [83]. Other sources of flexibility in degradation behavior are scaffold structural properties such as thickness, geometry, and surface area to volume ratio [84]. PLA and PGA degrade by hydrolysis, with the final products of lactic and glycolic acids either directly eliminated via the kidney or respiratory system or entering the Krebs cycle and being metabolized to carbon dioxide and water.…”

Section: Synthetic Polymersmentioning

confidence: 99%

Frontiers in urethra regeneration: current state and future perspective

Vasyutin¹,

Butnaru²,

Lyundup³

et al. 2021

Biomed. Mater.

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Despite the positive achievements attained, the treatment of male urethral strictures and hypospadiases still remains a challenge, particularly in cases of severe urethral defects. Complications and the need for additional interventions in such cases are common. Also, shortage of autologous tissue for graft harvesting and significant morbidity in the location of harvesting present problems and often lead to staged treatment. Tissue engineering provides a promising alternative to the current sources of grafts for urethroplasty. Since the first experiments in urethral substitution with tissue engineered grafts, this topic in regenerative medicine has grown remarkably, as many different types of tissue-engineered grafts and approaches in graft design have been suggested and tested in vivo. However, there have been only a few clinical trials of tissue-engineered grafts in urethral substitution, involving hardly more than a hundred patients overall. This indicates that the topic is still in its inception, and the search for the best graft design is continuing. The current review focuses on the state of the art in urethral regeneration with tissue engineering technology. It gives a comprehensive overview of the components of the tissue-engineered graft and an overview of the steps in graft development. Different cell sources, types of scaffolds, assembling approaches, options for vascularization enhancement and preclinical models are considered.

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Section: Synthetic Polymersmentioning

confidence: 99%

Frontiers in urethra regeneration: current state and future perspective

Vasyutin¹,

Butnaru²,

Lyundup³

et al. 2021

Biomed. Mater.

View full text Add to dashboard Cite

show abstract

A review on the use of computational methods to characterize, design, and optimize tissue engineering scaffolds, with a potential in 3D printing fabrication

et al. 2018

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The design and fabrication of tissue engineering scaffolds is a highly complex process. In order to provide a proper architecture for cells to grow, proliferate, and differentiate to form tissues, scaffolds have to be made with suitable properties. However, the limited structural designs and conventional fabrication techniques severely cripple the improvement of scaffold properties. To overcome these limitations, many researchers have recently adopted computational methods combined with 3D printing techniques as a new approach for scaffold design and fabrication. This approach allows scaffolds to be designed and fabricated with highly complex microstructures and good control and accuracy. Previous works have also shown this approach to be a very useful tool to predict the scaffold properties and to optimize the scaffold designs with a great reduction of experimental iterations. As this approach combining computational methods and 3D printing techniques for scaffold design and fabrication has many advantages over the conventional trial‐and‐error based approach, it is imperative to provide a state‐of‐the‐art review on the topic. To this end, this article reviews the various applications of computational methods in scaffold design and simulation; it also briefly reviews the application of 3D printing techniques to fabricate the computationally designed scaffolds. Finally, the limitations and future trends of this approach are discussed. Overall, this review will enable readers to understand the benefits of using computational methods coupled with 3D printing to design and fabricate scaffolds, and thus help researchers to improve and optimize the scaffold properties for future tissue engineering research. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1329–1351, 2019.

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Computer modeling of the degradation behavior of polyester-based tissue engineering scaffolds

Cited by 2 publications

References 31 publications

Frontiers in urethra regeneration: current state and future perspective

Frontiers in urethra regeneration: current state and future perspective

A review on the use of computational methods to characterize, design, and optimize tissue engineering scaffolds, with a potential in 3D printing fabrication

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