Computer Models for Metabolic Studies on Plasma Proteins

Fleck, A.

doi:10.1177/000456328502200103

Cited by 36 publications

(17 citation statements)

References 32 publications

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“…Following surgical trauma, the most significant factors contributing to the changes in serum albumin are dilution, absolute losses and redistribution (Fleck, 1985). Falling levels of plasma proteins may result from any combination of reduced synthesis, dilution, redistribution between intravascular and extravascular compartments, absolute losses (e.g.…”

Section: Discussionmentioning

confidence: 99%

Beta₂‐glycoprotein I in thrombosis: evidence for a role as a natural anticoagulant

Brighton

et al. 1996

Br J Haematol

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Although the physiological role of beta2-glycoprotein (B2GPI) is unknown, in vitro evidence indicates that B2GPI may be a natural anticoagulant. In this study we have examined whether fluctuations of plasma B2GPI occur in in vivo coagulation. Serial measurements of B2GPI and other anticoagulant proteins were performed in 51 patients with thrombotic (group 1: six patients with disseminated intravascular coagulation (DIC), group 2: venous (n = 4) or arterial (n = 170 thrombosis) and non-thrombotic disease (group 3: 24 patients undergoing elective surgery). Reductions in plasma B2GPI levels were seen in most patients which were roughly proportional to the severity of their illness. Particularly striking reductions of B2GPI, protein C (PC) and antithrombin III (AT-III) (mean +/- 95% CI: 42.7 +/- 8.6%, 42.1 +/- 14.8%, 39.1 +/- 28.4% respectively) were seen in group 1. The reductions in plasma B2GPI were significantly greater in group 1 than in the other groups. Dilutional factors explain most of the reductions in B2GPI, PC and AT-III in groups 2 and 3, but contribute little to group 1. In conclusion, although B2GPI behaves as a 'negative acute phase reactant', the magnitude of reduction of plasma B2GPI levels, accompanied by reductions in other anticoagulant proteins in patients with DIC, suggests specific consumption of B2GPI in in vivo coagulation. This study provides further evidence that B2GPI is an anticoagulant of physiological importance.

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Section: Discussionmentioning

confidence: 99%

Beta₂‐glycoprotein I in thrombosis: evidence for a role as a natural anticoagulant

Brighton

et al. 1996

Br J Haematol

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“…observations]. This compares with the normal catabolic rate of albumin of about 12 g/day, representing about 10% of the intravascular pool [23], CAPD patients maintain albumin homeostasis by decreased catabolism and increased synthesis [24] but in the face of such massive losses it seems likely that the half-life of albumin is de creased. It has been shown that when protein turnover is increased, as in hyperthyroidism, fructosamine decreases even in the absence of changes in protein concentration [25].…”

Section: Discussionmentioning

confidence: 92%

Serum Glycated Albumin and Fructosamine in Renal Dialysis Patients

Lamb

Venton²,

Cattell³

et al. 1993

Nephron

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The effect of uraemia on protein glycation was studied by measuring glycated albumin and fructosamine in 50 non-diabetic dialysis patients (31 continuous ambulatory peritoneal dialysis, CAPD, 19 haemodialysis). After correction for serum albumin concentration, glycated albumin (g/l00 g) was increased in the haemodialysis group (1.94 ± 0.40) compared with both CAPD patients (1.46 ± 0.37; p < 0.001) and controls (1.52 ± 0.29; p < 0.001), but did not differ between CAPD patients and controls (p > 0.05). Serum fructosamine, corrected for either serum albumin or total protein concentration (μmol/100 g), was raised in CAPD (828 ± 90, 386 ± 41, respectively) and haemodialysis patients (802 ± 123, 391 ± 42, respectively) compared with controls (609 ± 69, 332 ± 27, respectively; p < 0.0001 in all cases), but did not differ between the two dialysis groups (p > 0.05). A single haemodialysis cycle had no effect on the measurement of glycated albumin or fructosamine (p > 0.05). The results confirm that glycated protein levels are generally raised in dialysis patients. In CAPD patients, altered albumin metabolism resulting from large peritoneal losses is likely to have caused a decrease in the amount of albumin glycated, an effect less apparent on the concentration of fructosamine because of the additional contribution of glycated globulins.

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“…The mechanism of hypoalbuminemia in acute illness and major surgery is likely multifactorial. Impaired hepatic synthesis, acute phase protein down-regulation, increased capillary permeability, and expansion of the intravascular volume by crystalloid/colloid resuscitation are all potential mechanisms [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Comparative Quantitative Acid-Base Analysis in Coronary Artery Bypass, Severe Sepsis, and Diabetic Ketoacidosis

Omron

2005

J Intensive Care Med

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The main objective of this study was to assess the relationship of standard base excess (SBE) to delta strong ion difference effective (DeltaSIDe) in critical illness. Critical illness is characterized by variable plasma nonvolatile weak acid components (DeltaA(-)), and SBE becomes discordant with DeltaSIDe. The author hypothesized that both acid-base models are equivalent when SBE and DeltaSIDe are corrected for DeltaA(-). A retrospective chart review was performed to assess this hypothesis by looking at changes in SBE, DeltaSIDe, and DeltaA(-) in 30 coronary artery bypass graft surgery patients, 30 severe sepsis patients, and 15 diabetic ketoacidosis patients. SBE equals the sum of the DeltaSIDe and DeltaA(-). The SBE quantifies the magnitude of the metabolic acid-base derangement, the DeltaSIDe quantifies the plasma strong cation/anion imbalance, and the DeltaA(-) quantifies the magnitude of the hypoalbuminemic alkalosis. The partitioning of SBE into physicochemical components can facilitate analyses of complex acid-base disorders in critical illness.

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Computer Models for Metabolic Studies on Plasma Proteins

Cited by 36 publications

References 32 publications

Beta₂‐glycoprotein I in thrombosis: evidence for a role as a natural anticoagulant

Beta₂‐glycoprotein I in thrombosis: evidence for a role as a natural anticoagulant

Serum Glycated Albumin and Fructosamine in Renal Dialysis Patients

Comparative Quantitative Acid-Base Analysis in Coronary Artery Bypass, Severe Sepsis, and Diabetic Ketoacidosis

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Computer Models for Metabolic Studies on Plasma Proteins

Cited by 36 publications

References 32 publications

Beta2‐glycoprotein I in thrombosis: evidence for a role as a natural anticoagulant

Beta2‐glycoprotein I in thrombosis: evidence for a role as a natural anticoagulant

Serum Glycated Albumin and Fructosamine in Renal Dialysis Patients

Comparative Quantitative Acid-Base Analysis in Coronary Artery Bypass, Severe Sepsis, and Diabetic Ketoacidosis

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Product

Resources

About

Beta₂‐glycoprotein I in thrombosis: evidence for a role as a natural anticoagulant

Beta₂‐glycoprotein I in thrombosis: evidence for a role as a natural anticoagulant