Computer simulation of pressure welding of cylindrical workpieces through an interlayer was carried out using the DEFORM-2D software package in a two-dimensional formulation (axisymmetric deformation). Two combinations of materials to weld were considered: sample I -cylinders of heterophase nickel-based deformable superalloy EP975 in a coarsegrained state were welded through an interlayer of EP975 with a fine-grained microduplex structure; sample II -cylinders of dissimilar nickel-based alloys, one the deformable alloy EP975 in a coarse-grained state and the other an intermetallic alloy VKNA-25 with a single-crystal structure, were welded through an interlayer of EP975 alloy with a fine-grained microduplex structure. The welding process was carried out under isothermal conditions at a temperature of 1125°C and an initial strain rate of 10 −4 s −1 . The material characteristics were described by experimental curves obtained under uniaxial compression tests of alloys at the welding temperature. The Siebel friction model was used to describe the contact conditions on the surfaces to be welded. The friction coefficient was taken equal to 0.3. The distribution of equivalent, axial, radial, circumferential and shear components of stress and strain in the samples have been investigated. Analysis of the simulation results allowed one to conclude that, in comparison to welding of similar materials, during welding of dissimilar materials the values of the radial, axial and circumferential stresses increase. Radial and circumferential stresses in the material of the cylinders are tensile, while compressive stresses prevail in the material of the interlayer. Area with the maximum values of shear stresses in the region of contact between the cylinders and the interlayer also increases. In this case, axial, radial and circumferential strains decrease in a cylinder made from a material with higher strength, the overall level of shear strain does not change, and on the reciprocal contact surface of the interlayer, the region of extension of maximum shear strain extends to the entire contact zone. Such a combination of factors allows one to conclude on more favorable pressure welding conditions for welding of dissimilar alloys in comparison with similar materials.