Computer Simulations of Transport Processes

Abstract

He received the BS degree from the University of Michigan and the MS and PhD degrees from Massachusetts Institute of Technology. Before joining the University of Pittsburgh, he was associated vrith A bear Inc., Cambridge, MA. During the year 1970-71, he was a visiting scholar at the University of Cambridge, Cambridge, U.K, He presently teaches courses in reaction engineering and has research interests in reaction engineering and special types of transport phenomena.Recent developments in computer technology have created a significant impact on our theoretical as well as practical understandings of the transport processes. The problems, which appeared rather impossible to comprehend previously, are now evaluated easily with the help of a computer. Thus, a computer simulation has become an intimate and important part of the study of transport phenomena.The advantages of a computer simulation are manyfold. It allows a rapid and relatively inexpensive evaluation of a complex process. It is almost essential for the identification, optimization, and control studies of a complex process. It can

Involvement of Pazopanib and Sunitinib Aldehyde Reactive Metabolites in Toxicity and Drug–Drug Interactions in Vitro and in Patient Samples

“…Shah et al indeed reported that 25−35% of clinical trial patients treated with TKI showed a low-grade elevation in alanine and/or aspartate aminotransferases, and approximately 2% of them developed high-grade increases in serum transaminases, with a wide variability among TKI. 8 Although little is known about the underlying mechanisms, it is thought that liver toxicity could be due to reactive metabolites (RM) and as well as being immune-related. RM reactivity is associated with the presence of electrophilic moieties or radicals originating from the metabolic transformation, often called bioactivation, of particular functional groups known as structural alerts or toxicophores.…”