“…Computer-based brain tumor segmentation has remained largely experimental work, with approaches including multi-spectral analysis 50,51,55,54,29,19 , edge detection 21, 1 2 , 45, 22, 6 0 , 5 9 , 2 , neural networks 35, 3 0 , 4 4 , and knowledge-based techniques 25,42,37,13,28 . Our e orts in 34,7,6 showed that a combination of knowledge-based techniques and multi-spectral analysis could e ectively detect pathology and label normal transaxial slices.…”