Computerised Analysis of Fetal Behaviour

Vindla, Srinivas; Sahota, Daljit Singh; Coppens, Marc; James, David

doi:10.1159/000264497

Cited by 9 publications

(18 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The evaluation of fetal brain function should allow the characterisation of normal functional neurodevelopment and its disturbance in various pathologies. Until recently, the only methods available to assess fetal brain function in utero have been the indirect study of fetal heart rate responses [Vindla et al, 1997] and magnetoencephalography (MEG) [Blum et al, 1985;Eswaran et al, 2002]. Functional magnetic resonance imaging (fMRI) has become a well-established method for determining the patterns of brain activation following stimulus presentation in the adult.…”

Section: Introductionmentioning

confidence: 99%

Fetal brain activity in response to a visual stimulus

Fulford

Vadeyar

Dodampahala

et al. 2003

Human Brain Mapping

Self Cite

103

View full text Add to dashboard Cite

Previous studies have demonstrated the use of functional magnetic resonance imaging (fMRI) to assess fetal brain activity. To extend these studies, a fetal fMRI experiment using a visual stimulus has been performed at 0.5 T. This used a block fMRI paradigm with a bright, constant-intensity light source being shone at the maternal abdomen for 8 sec followed by 16 sec of darkness. This was repeated typically 40 times on nine subjects all of whom were greater than 36 weeks gestational age. Of these, one could not be analysed due to motion, three did not show significant activation, and five showed significant activation (P < 0.0085). In all cases, activation was localised within the frontal cortex. Exact localisation was difficult but this may correspond to the frontal eye fields and dorsolateral prefontal cortex. In no cases was significant activation present within the occipital region as would have been expected and was observed in 2/8 adult subjects. Hum. Brain Mapping 20:239-245, 2003.

show abstract

Section: Introductionmentioning

confidence: 99%

Fetal brain activity in response to a visual stimulus

Fulford

Vadeyar

Dodampahala

et al. 2003

Human Brain Mapping

Self Cite

103

View full text Add to dashboard Cite

show abstract

“…For this study the threshold was set at the 40% level. This was determined as the optimum setting by initial validation of the TEAM fetal activity detector in comparison with the conventional method of determining fetal activity using simultaneous observation with real‐time ultrasound for one‐hour recordings in 20 women with normal term pregnancies 5 . Receiver–operator characteristic curves were constructed, comparing observed fetal activity (body and limb movements) using real‐time ultrasound with that detected using the Doppler transducer of the TEAM monitor at different threshold levels of the low‐pass filter output.…”

Section: Methodsmentioning

confidence: 99%

“…At a setting of 40%, the presence of a Doppler‐generated signal from the TEAM monitor was likely to be associated with observed fetal movement on ultrasound within a three‐second window (SD 1.5s) with a sensitivity of 76% and a specificity of 75%. Further details on the validation are described by Vindla et al 5 . and can be obtained from the authors on request.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A comparison of fetal behaviour in term fetuses exposed to anticonvulsant medication with unexposed controls

Kean

Gargari

Suwanrath

et al. 2001

BJOG: An Internal Journal of Obs Gyn

View full text Add to dashboard Cite

Objective To compare behaviour in term fetuses exposed to anticonvulsants with unexposed controls. Design An observational study.Setting Pregnancy Assessment Centre, University Hospital, Nottingham, UK. Sample Seventeen fetuses whose mothers were taking anticonvulsants and 94 fetuses whose mothers were on no medication between 28 and 41 weeks. Methods Behaviour (fetal heart rate and activity) was recorded with the use of Doppler ultrasound. The duration of recording was 60 minutes or more in all but four recordings (minimum 49 minutes). Main outcome measures Behavioural criteria studied were: 1. the relative percentage time spent in low and high variation fetal heart rate patterns; 2. the duration and recurrence of fetal activity; 3. the number of accelerations in low and high fetal heart rate variation; and 4. the number of fetal behavioural state transitions. Results The two groups were comparable in terms of maternal age, parity, birthweight, Apgar scores and absence of neonatal problems. There was less fetal activity in the anticonvulsant group, but this was only statistically significant at 33-36 weeks in fetal heart rate pattern B (equivalent to state 2F). Conclusions This study showed that fetuses exposed to anticonvulsant medication exhibited a trend of being less active. There were no other significant differences in behaviour. The data do not support the hypothesis of substantial differences in behaviour in fetuses exposed to anticonvulsants.

show abstract

“…At a setting of 40% the presence of a Doppler-generated positive signal from the TEAM monitor was likely to be associated with an observed fetal movement observed on ultrasound within a 3-second window with a sensitivity of 76% and a specificity of 75%. A fuller description of the validation can be found in Vindla et al [19].…”

Section: Signal Acquisitionmentioning

confidence: 99%

Comparison of Unstimulated and Stimulated Behaviour in Human Fetuses with Congenital Abnormalities

Vindla¹,

James²,

Sahota³

1999

Fetal Diagn Ther

Self Cite

View full text Add to dashboard Cite

Unstimulated (passive) and stimulated behaviour [fetal heart rate (FHR) and movements (FA)] was studied in 32 normal fetuses and 10 fetuses with congenital abnormalities (CA). FHR and FA were recorded using a single 1.5-MHz ultrasound transducer and analysed by computer. A 5-second vibroacoustic stimulus (VAS) (‘electronic artificial larynx’) was used for the stimulation studies. Thus, passive and stimulated behaviour could be studied in a group of fetuses with known pathologies. One hour was used as the recording time for the passive studies and 20 min for the stimulation studies (10 min pre- and 10 min post-VAS). All CA fetuses had abnormalities of FHR and/or FA on recording passive behaviour compared to normal fetuses. However, 4 of the 10 fetuses with CA had responses to VAS that were within the normal range for both FHR and FA. We do not feel that computerised assessment of stimulated behaviour in fetuses with CA confers any advantage over analysis of passive behaviour.

show abstract

Computerised Analysis of Fetal Behaviour

Cited by 9 publications

References 10 publications

Fetal brain activity in response to a visual stimulus

Fetal brain activity in response to a visual stimulus

A comparison of fetal behaviour in term fetuses exposed to anticonvulsant medication with unexposed controls

Comparison of Unstimulated and Stimulated Behaviour in Human Fetuses with Congenital Abnormalities

Contact Info

Product

Resources

About