Computerized assessment of cognitive late effects among adolescent brain tumor survivors

Conklin, Heather M.; Ashford, Jason M.; Pinto, Marcos Di; Vaughan, Christopher G.; Gioia, Gérard A.; Merchant, Thomas E.; Ogg, Robert J.; Santana, Víctor M.; Wu, Shengjie

doi:10.1007/s11060-013-1123-5

Cited by 31 publications

(26 citation statements)

References 32 publications

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“…Within a diverse brain tumor group treated with radiation, hydrocephalus is associated with poorer outcome (Conklin et al, 2013). In survivors of childhood medulloblastoma, all treated with surgery, radiation, and chemotherapy, shunt placement for hydrocephalus after tumor resection is associated with poorer neurocognitive outcome (Hardy et al, 2008).…”

Section: When To Assessmentioning

confidence: 99%

Functional Plasticity in Childhood Brain Disorders: When, What, How, and Whom to Assess

et al. 2014

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At every point in the lifespan, the brain balances malleable processes representing neural plasticity that promote change with homeostatic processes that promote stability. Whether a child develops typically or with brain injury, his or her neural and behavioral outcome is constructed through transactions between plastic and homeostatic processes and the environment. In clinical research with children in whom the developing brain has been malformed or injured, behavioral outcomes provide an index of the result of plasticity, homeostasis, and environmental transactions. When should we assess outcome in relation to age at brain insult, time since brain insult, and age of the child at testing? What should we measure? Functions involving reacting to the past and predicting the future, as well as social-affective skills, are important. How should we assess outcome? Information from performance variability, direct measures and informants, overt and covert measures, and laboratory and ecological measures should be considered. In whom are we assessing outcome? Assessment should be cognizant of individual differences in gene, socio-economic status (SES), parenting, nutrition, and interpersonal supports, which are moderators that interact with other factors influencing functional outcome.

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Section: When To Assessmentioning

confidence: 99%

Functional Plasticity in Childhood Brain Disorders: When, What, How, and Whom to Assess

et al. 2014

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“…These include global intellectual decline (i.e., IQ) as well as declines in specific neurocognitive domains, including attention, executive function, processing speed, working memory, memory, visual-spatial, visual-motor, and fine motor skills (Armstrong, 2006; Armstrong & Briery, 2004; Ashford et al, 2010; Buizer, de Sonneville, & Veerman, 2009; Conklin et al, 2013; Conklin, Ashford et al, 2012; Kahalley et al, 2013; Langer et al, 2002). Structural alteration of white matter tracts (e.g., damage to existing tracts, disruption of developing tracts) in the developing brain is considered a primary cause of cognitive late effects (Mulhern et al, 2004; Schatz, Kramer, Ablin, & Matthay, 2000).…”

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confidence: 99%

Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia

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et al. 2014

Journal of Clinical and Experimental Neuropsychology

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BACKGROUND Survivors of pediatric brain tumors (BT) and acute lymphoblastic leukemia (ALL) are at risk for neurocognitive late effects related to executive function. PROCEDURE Survivors of BT (48) and ALL (50) completed neurocognitive assessment. Executive function was compared to estimated IQ and population norms by diagnostic group. RESULTS Both BT and ALL demonstrated relative executive function weaknesses. As a group, BT survivors demonstrated weaker executive functioning than expected for age. Those BT survivors with deficits exhibited a profile suggestive of global executive dysfunction, while affected ALL survivors tended to demonstrate specific rapid naming deficits. CONCLUSION Findings suggest that pediatric BT and ALL survivors may exhibit different profiles of executive function late effects, which may necessitate distinct intervention plans.

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“…[14][15][16] Studies suggest that, although there may be an improvement in cognitive function two years after the moderate or severe trauma, these functions still remain impaired. 17 The QL deals with the subjective perceptions of different aspects, being of a personal and mutable nature varying according to the individual's context, interests, and values.…”

Section: Discussionmentioning

confidence: 99%

Traumatic brain injury and its implications on cognition and quality of life

et al. 2015

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Traumatic brain injury is one of the main causes of mortality in children or young adults. Patients with moderate or severe TBI can present motor, cognitive, emotional, behavioral, and social functionality sequelae, causing an adverse impact on the individual, his family, and on society. Objective: To investigate the impact that severe traumatic brain injury caused to the life of patients who suffered the injury during childhood and youth, considering cognitive, emotional, and quality of life questions, as well as, to verify whether there are differences with respect to age at the time of injury. Method: A quantitative, qualitative, cross-sectional study carried out at the Ibirapuera unit of the Rehabilitation Center of the Association for Assistance to Disabled Children (AACD). Thirteen patients with severe traumatic brain injury from São Paulo state, participated in the study between January of 2010 and March of 2014. The instruments utilized were: a sociodemographic questionnaire, the Short Form Health Survey (SF-36), the Raven's Progressive Matrices, and the Pfister Colored Pyramid Test. The data collected were evaluated in the overall sample and then divided into two groups based on their age at the time of injury, with group 1 (3 to 7 years and eleven months old) and group 2 (8 to 16 years and eleven months old). Results: On the Raven's test, 76.9% of the participants showed signs of mental impairment. All participants had a good quality of life assessment. In the emotional aspects, there was good adaptability and interaction. Upon comparison, there was no difference between groups. Conclusion: The results were consistent with studies that indicate cognitive impairment and good perception of quality of life. Arruda BP, Akamatsu PYF, Xavier AP, Costa RCV, Oliveira-Alonso GS, Madaleno IMP Traumatic brain injury and its implications on cognition and quality of life Keywords

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Computerized assessment of cognitive late effects among adolescent brain tumor survivors

Cited by 31 publications

References 32 publications

Functional Plasticity in Childhood Brain Disorders: When, What, How, and Whom to Assess

Functional Plasticity in Childhood Brain Disorders: When, What, How, and Whom to Assess

Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia

Traumatic brain injury and its implications on cognition and quality of life

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