Computerized cognitive remediation improves verbal learning and processing speed in schizophrenia

Sartory, Gudrun; Zorn, C.; Groetzinger, Gerd; Windgassen, Klaus

doi:10.1016/j.schres.2004.10.004

Cited by 135 publications

(76 citation statements)

References 23 publications

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“…The results of this study are in line with most other studies (16,17), particularly the study by Prouteau et al, 2005 (12). We provided a relatively short course of remediation that would be more practical and less costly, especially in less developed or resourceful settings.…”

Section: Discussionsupporting

confidence: 93%

The Effect of a Computer-Assisted Cognitive Remediation on Improving Cognitive Functions in Patients with Schizophrenia: A Before-After Study

Sharifi

Sedighnia

Ataie

et al. 2016

Iran J Psychiatry Behav Sci

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Background: Cognitive impairment is a chronic and disabling manifestation of schizophrenia. Objectives: This before-after study was conducted to examine the effect of a short course computer-assisted cognitive remediation on improving cognitive functions of patients with schizophrenia. Materials and Methods: Twenty patients with schizophrenia were enrolled into the study. The intervention consisted of 10 onehour sessions held 2-3 times a week, using the Cogpack software that includes tasks to improve attention, memory, and executive function. The patients' cognitive functioning was assessed before and after the remediation, using tests in the CANTAB battery, including stop signal task (SST) and choice reaction time (CRT) to assess attention levels, pattern recognition memory (PRM) and Paired associate learning (PAL) to examine memory, and stocking of Cambridge (SOC) and intra-extra dimensional task (IED) to evaluate executive function. Results: IED and SOC revealed a statistically significant improvement in executive function after the intervention. PAL revealed a significant improvement in memory functioning in most aspects after the intervention, while PRM did not. CRT showed a significant improvement in some aspects of attention and concentration after the intervention, while SST did not. Conclusions: This before-after study revealed that a relatively short course of a computer-assisted cognitive remediation can be applied to improve several aspects of cognitive functioning in patients with schizophrenia. A randomized controlled trial is required to establish the effectiveness of the intervention.

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Section: Discussionsupporting

confidence: 93%

The Effect of a Computer-Assisted Cognitive Remediation on Improving Cognitive Functions in Patients with Schizophrenia: A Before-After Study

Sharifi

Sedighnia

Ataie

et al. 2016

Iran J Psychiatry Behav Sci

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“…There was a tendency for stable deficit in the majority of cognitive deficits, with the exception of verbal learning and two measures of processing speed, which have a marked poorer trajectory. However, these cognitive impairments in psychosis are malleable as cognitive remediation has improved performance in first episode psychosis and schizophrenia (Østergaard Christensen et al, 2014;Sartory et al, 2005). Speed of processing performance may moderate deficits in additional cognitive domains in psychosis and negative symptoms four years after a psychotic episode appeared to be partially predicted by performance on reasoning and problem solving and social cognition at illness onset.…”

Section: Resultsmentioning

confidence: 99%

Cognitive course in first-episode psychosis and clinical correlates: A 4 year longitudinal study using the MATRICS Consensus Cognitive Battery

Kenney

Anderson‐Schmidt

Scanlon

et al. 2015

Schizophrenia Research

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While cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of specific cognitive domains after illness onset. This study investigates the longitudinal course of cognitive deficits four years after a first-episode of psychosis and the relationship of performance with clinical course and response to treatment.Twenty three individuals with psychotic illness, matched with 21 healthy volunteers, were assessed using the MATRICS Consensus Cognitive Battery at illness onset and 4 years later. We also investigated the relationship between cognitive deficits and quality of life and clinical indices.Verbal learning and two measures of processing speed had marked poorer trajectory over four years compared to the remaining cognitive domains. Processing speed performance was found to contribute to the cognitive deficits in psychosis. Poorer clinical outcome was associated with greater deficits at illness onset in reasoning and problem solving and social cognition. Cognitive deficits did not predict quality of life at follow-up, nor did diagnosis subtype differentiate cognitive performance.In conclusion, an initial psychotic episode may be associated with an additional cost on verbal learning and two measures of processing speed over a time spanning at least four years. Moreover, processing speed, which has been manipulated through intervention in previous studies, may represent a viable therapeutic target. Finally, cognition at illness onset may have a predictive capability of illness course.

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“…Patients performed tasks designed to train attention and memory from the battery available within a computerized software package (CogPack Marker Software). This training protocol has been shown to improve memory and executive functioning in patients with schizophrenia (Sartory et al, 2005) and tasks chosen were designed to produce improved working memory and attention capacity in the treated group. In addition, patients in the REM group trained on the word N-back one to two times a week and on N-back tasks using a variety of other stimuli (such as faces) one to two times a week to support the generalization of working memory improvements.…”

Section: Methodsmentioning

confidence: 99%

Prefrontal Cortical Changes Following Cognitive Training in Patients with Chronic Schizophrenia: Effects of Practice, Generalization, and Specificity

Haut

Lim

MacDonald

2010

Neuropsychopharmacol

153

120

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Cognitive training is increasingly used in the treatment of schizophrenia, but it remains unknown how this training affects functional neuroanatomy. Practice on specific cognitive tasks generally leads to automaticity and decreased prefrontal cortical activity, yet broadbased cognitive training programs may avoid automaticity and increase prefrontal cortex (PFC) activity. This study used quasirandomized, placebo-control design and pre/post neuroimaging to examine functional plasticity associated with attention and working memory-focused cognitive training in patients with schizophrenia. Twenty-one participants with schizophrenia or schizoaffective disorder split into two demographically and performance matched groups (nine scanned per group) and nine control participants were tested 6-8 weeks apart. Compared with both patient controls and healthy controls, patients receiving cognitive training increased activation significantly more in attention and working memory networks, including dorsolateral prefrontal cortex, anterior cingulate and frontopolar cortex. The extent to which activity increased in a subset of these regions predicted performance improvements. Although this study was not designed to speak to the efficacy of cognitive training as a treatment, it is the first study to show that such training can increase the ability of patients to activate the PFC regions subserving attention and working memory.

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Computerized cognitive remediation improves verbal learning and processing speed in schizophrenia

Cited by 135 publications

References 23 publications

The Effect of a Computer-Assisted Cognitive Remediation on Improving Cognitive Functions in Patients with Schizophrenia: A Before-After Study

The Effect of a Computer-Assisted Cognitive Remediation on Improving Cognitive Functions in Patients with Schizophrenia: A Before-After Study

Cognitive course in first-episode psychosis and clinical correlates: A 4 year longitudinal study using the MATRICS Consensus Cognitive Battery

Prefrontal Cortical Changes Following Cognitive Training in Patients with Chronic Schizophrenia: Effects of Practice, Generalization, and Specificity

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