Computers in Medicine: Past, Present, and Potential*

Talbott, G. Douglas

doi:10.1111/j.1532-5415.1966.tb02921.x

Cited by 2 publications

(2 citation statements)

References 42 publications

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“…Since that time many authors have also commented on the frequency of coronary and peripheral arterial disease in gout. Despite these findings Talbott & Lilienfeld (1959) surprisingly state that the general mortality rate of gouty patients is not worse than that of the general population. Over the last ten to fifteen years there has been an increasing interest in the role which lipids play in the pathogenesis of atherosclerosis, especially with regard to elevated blood levels and the presence of lipids in the arterial lesions of both man and experimental animals.…”

Section: Lipid Metabolism In Goutmentioning

confidence: 87%

Lipid Metabolism in Gout

1966

Proceedings of the Royal Society of Medicine

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The distribution is gaussian with a positive skew in all races and with a suggestion of bimodality. The main peak occurs at 4 5 to 6 mg/l00 ml in males with a small secondary peak at 6 to 8 3 mg/100 ml in different races. In females the main peak is 1 mg/100 ml lower and the secondary peak less evident.First-degree relatives of gouty and hyperuricemic persons in north-west England had a similar distribution of serum uric acid levels to members of the Pacific races and had significantly more hyperuricemia than the local populations as a whole. Their spouses showed more serum uric acid levels above 5'5 mg/100 ml than the rest of the population but had less hyperuricwmia than the relatives.Obesity was more frequent than expected in gouty probands and their male relatives but not in non-gouty hyperuriczmics or their relatives.A combination of multiple genetic and environmental factors is postulated as determining the occurrence of hyperuricemia.

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Section: Lipid Metabolism In Goutmentioning

confidence: 87%

Lipid Metabolism in Gout

1966

Proceedings of the Royal Society of Medicine

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“…Although there was an increased lymph flow and lipid and protein output, mainly in the first hour after ethanol administration (intragastric or intraduodenal route), no hypedipemia occurred under these conditions. These findings seem curious, because it is well known that ingestion of ethanol with a high fat meal enhances the usual postprandial lipemia in man (13)(14)(15) and in animals (16,17). Moreover, a gastric retention of fats and proteins has been observed after ethanol ingestion (4) which might explain the prolonged postprandial lipemia.…”

Section: Introductionmentioning

confidence: 99%

Effect of acute ethanol ingestion on fat absorption

Boquillon¹

1976

Lipids

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A test meal (300 mg casein, 600 mg sucrose, 100 mg corn oil, tracer dose of 9.10(3)H oleic acid) was given to fasting adult rats with intestinal lymph fistulas. One group received an acute oral dose of ethanol (3.2 g/kg body weight) simultaneously with the test meal. Controls received 2.5 ml of water instead of ethanol. Ingestion of ethanol temporarily delayed the removal of lipid radioactivity from the stomachs. More than 25% of radioactivity fed remained 8 hr after feeding whereas with control rats less than 10% of lipid radioactivity fed remained 6 hr after feeding. In controls and ethanol-treated rats, the amounts of exogenous lipids in the intestinal lumen and mucosa were low and similar enough. Quantities of endogenous and exogenous lipids found in the lymph collected during 24 hr after feeding were similar in the two groups, but the fat absorption peak was found after 6 hr in alcoholic rats and before 6 hr in controls. This delay was probably due to the retention of lipids in the stomach. More of the exogenous lipid was always transported by small particles moving in the region of alpha1 globulins in cellulose acetate electrophoresis than by larger particles remaining at the origin. This proportion was enhanced in the ethanol-treated animals. The larger fat particles were richer in endogenous fatty acids in alcohol-treated rats than in controls.

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Computers in Medicine: Past, Present, and Potential*

Cited by 2 publications

References 42 publications

Lipid Metabolism in Gout

Lipid Metabolism in Gout

Effect of acute ethanol ingestion on fat absorption

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