Computertomographische Vorhersagbarkeit Lokaler Rezidive nach primär operativer Resektion von Oropharynxkarzinomen

Abstract

After primary surgery, oropharyngeal carcinomas with midline crossing have an increased risk of local recurrence, whereas the tumor volume only has a minor impact on the recurrence rate. This is in contrast to laryngeal or hypopharyngeal carcinomas.

CT-based volumetric tumor growth velocity: A novel imaging prognostic indicator in oropharyngeal cancer patients receiving radiotherapy

“…Many investigators have examined the prognostic impact of pretreatment CT tumor volume as compared to tumor stage in oropharyngeal cancer, and found no significant association between tumor volume and local control in patients treated with radiotherapy 5,8 or surgery 7 , although some did find a significant association between T stage and local control. Hermans et al found a significant correlation between tumor volume and local recurrence, but only for T1 tumors.…”

“…Tumor volume calculations performed according to our methodology are generally believed to be within 10–20% of true tumor volume as previously demonstrated in several prior publications. 2,7,21,22 Recently, Caldas-Magalhaes et al demonstrated that GTVs delineated on CT for laryngeal and hypopharyngeal cancer were 1.7 times larger than the tumor measured on the Hematoxylin-eosin stained pathological sections of the same tumor after surgical resection and registration the respective CT delineations. 23 Also, the first scan utilized could be acquired at an outside hospital with different scanner and different slice thickness than the second scan, which was always done at MD Anderson.…”

Volumetric stratification of cT4 stage head and neck cancer

“…Most published volumetric focused outcome analyses were based on dichotomizing the GTV (i.e., using just one cut-off), ( Tab. 3 , [ 4 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]). Four [ 17 , 18 , 20 , 25 ] of the 31 listed reports were based on two or three cut-off values, our own system included.…”