Let E be an elliptic curve without complex multiplication defined over the rationals. The purpose of this article is to define a positive integer A(E), that we call the Serre's constant associated to E, that gives necessary conditions to conclude that ρE,m, the mod m Galois representation associated to E, is non-surjective. In particular, if there exists a prime factor p of m satisfying valp(m) ≥ valp(A(E)) > 0 then ρE,m is non-surjective. Conditionally under Serre's Uniformity Conjecture, we determine all the Serre's constants of elliptic curves without complex multiplication over the rationals that occur infinitely often. Moreover, we give all the possible combination of mod p Galois representations that occur for infinitely many non-isomorphic classes of non-CM elliptic curves over Q, and the known cases that appear only finitely. We obtain similar results for the possible combination of maximal non-surjective subgroups of GL2(Zp). Finally, we conjecture all the possibilities of these combinations and in particular all the possibilities of these Serre's constants.Serre's Uniformity Question. If E/Q is a non-CM elliptic curve, then must it be that ρ E,p is surjective for any prime p ≥ 41?Nowadays, an affirmative answer to the above question has received the name of Serre's Uniformity Conjecture (or sometimes just Uniformity Conjecture) despite the fact that Serre himself never conjectured it to be true.