COMT rs4818, pain sensitivity and duration, and alveolar bone grafting of oral clefts

Silva, E M V M; Lacerda, Rosa Helena Wanderley; Farias, I L; Cavalcante, B G N; Assis, Ionária Oliveira de; Bezamat, Mariana; Modesto, Adriana; Vieira, Alexandre R.

doi:10.1007/s10006-020-00912-0

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…Catechol-O-methyltransferase catalyses the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine, 20 and was associated with psychiatric disease and treatment response with antipsychotic medication, 21 suicide behaviour, 22 schizophrenia, 23 and pain modulation. 24 Our results are in line with previous findings.…”

Section: Discussionsupporting

confidence: 94%

COMT rs4818 less common allele is associated with psychological and psychiatric worse indicators in a cohort of individuals born with cleft lip and palate

Vieira

Barros

Soares

et al. 2022

Orthod Craniofacial Res

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Objective Individuals born with cleft lip and palate may face difficulties in speech function, nutrition, facial aesthetics, and long‐term care. These difficulties may increase the risk of psychological and psychiatric diseases. This work aimed to test if the variant allele of COMT was carried more frequently among individuals that have psychological and psychiatric outcomes within a cohort of patients born with cleft lip and palate. Method DNA extraction from saliva of two hundred and fifteen individuals born with cleft lip with and/or palate and genotyping was performed, and the frequency of COMT rs4818 alleles was determined. The domain ‘Psychological Function’ of Cleft‐Q™ was used to generate scores for analysis. The scores were computed, and differences in genotype or allele frequencies between individuals with psychological function scores 60 or above and 59 or below were compared. The history of psychiatric illness (family history of psychiatric disease or self‐reported psychiatric illness) was registered. Results Genotype and allele frequencies were compared between individuals with and without a family history of psychiatric illness. Individuals with lower Psychological Function (Cleft‐Q™) scores were more likely to be GG (P = .04) or carriers of allele G (P < .001). The reported psychiatric illness and positive family history of psychiatric illness were compared to COMT rs4818 allele and genotype frequencies of individuals without these indicators, and individuals with psychiatric illness and positive family history of psychiatric illness were more likely to carry allele G (P = .03 and P = .008, respectively). Conclusion The study confirms previously suggested role of COMT rs4818 in psychiatric and psychological outcomes in a distinct cohort of patients born with cleft lip and palate.

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Section: Discussionsupporting

confidence: 94%

COMT rs4818 less common allele is associated with psychological and psychiatric worse indicators in a cohort of individuals born with cleft lip and palate

Vieira

Barros

Soares

et al. 2022

Orthod Craniofacial Res

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“…Therefore, the association of the rs4818 SNP with disease of the tongue in the African-American group that received less anesthesia should be considered with caution as it may be linked to other disparities, as ethnic groups vary in lifestyle, socioeconomic conditions and access to dental services [ 8 , 36 ]. The rs4818 G allele (polymorphic) was reported to be protective for oral pain [ 11 ]. The same allele has been also associated with the risk of developing one of the most common diseases of the tongue, known as benign migratory glossitis, with a risk 4.7 times greater for developing the condition in individuals with the GC genotype [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Pain perception genes, asthma, and oral health: A reverse genetics study

Lisboa

Sekula²,

Bezamat³

et al. 2022

PLoS ONE

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Pain is an experience of a subjective nature, interpreted in a personal way and according to an extensive palette of factors unique to each individual. Orofacial pain can be acute or chronic and it is usually the main reason for the patient to seek dental care. Pain perception varies widely among individuals. This variability is considered a mosaic of factors, which include biopsychosocial factors and genetic factors. Understanding these differences can be extremely beneficial for pain management in a personalized and more efficient way. We performed association studies to investigate phenotypes associated with genetic markers in pain-related genes in two groups of patients who received more or less anesthesia during dental treatment. The study group was comprised of 1289 individuals participating in the Dental Registry and DNA Repository Project (DRDR) of the University of Pittsburgh, with 900 participants in the group that received the most anesthesia and 389 constituting the comparison group that received less anesthesia. We tested 58 phenotypes and genotypic data of seven SNPs in genes that are associated with pain perception, pain modulation and response to drugs used in pain treatment: COMT (rs4818 and rs6269), GCH1 (rs3783641), DRD2 (rs6276), OPRM1 (rs1799971), SCN9A (rs6746030) and SCN10A (rs6795970). The analysis revealed a protective effect of rs1799971 on asthma in the total sample. rs3783641 was associated with salivary secretion disorders in females who received more anesthesia. rs1799971 was also associated with periodontitis in Whites who received less anesthesia. rs4818 was associated with disease and other tongue conditions in the group composed of Blacks who received less anesthesia. In conclusion, our study implicated variants in pain-related genes in asthma and oral phenotypes.

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“…Among carriers of the GG genotype of the rs1799971 polymorphism ( OPMR1 gene), those participants with the CG carriers of the rs4818 polymorphism ( COMT gene) showed the highest pain catastrophizing, while within those carrying the AG genotype of the rs1799971 polymorphism, GG carriers of the rs4818 reported the highest pain catastrophizing. Interestingly, a recent article found a protective effect of G allele of rs4818 for postoperative pain sensibility and duration [ 41 ]. An inspiring study has suggested that opioid and serotonergic mechanisms (i.e.…”

Section: Discussionmentioning

confidence: 99%

Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project

et al. 2021

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Objectives It is widely acknowledged that the experience of pain is promoted by both genetic susceptibility and environmental factors such as engaging in physical activity (PA) and that pain-related cognitions are also important. Thus, the purpose of the present study was to test the association of 64 polymorphisms (34 candidate-genes) and the gene-gene, gene-PA, and gene-sedentary behaviour interactions with pain and pain-related cognitions in women with fibromyalgia. Methods Saliva samples from 274 women with fibromyalgia (aged 51.7 ± 7.7 years) were collected for extracting DNA. We measured PA and sedentary behaviour by accelerometers for a week, pain with algometry and questionnaires, and pain-related cognitions with questionnaires. To assess the robustness of the results, a meta-analysis was also performed. Results The rs6311 and rs6313 polymorphisms (HTR2A) were individually related to algometer scores. The interaction of rs4818 (COMT) and rs1799971 (OPRM1) was related to pain catastrophizing. Five gene-behaviour interactions were significant: the interactions of sedentary behaviour with rs1383914 (ADR1A), rs6860 (CHMP1A), rs4680 (COMT), rs165599 (COMT) and rs12994338 (SCN9A) on bodily pain subscale of the SF-36. Furthermore, the meta-analysis showed an association between rs4680 (COMT) and severity of fibromyalgia symptoms (codominant model, p-value: 0.032). Conclusion The HTR2A gene (individually), COMT and OPRM1 gene-gene interaction, and the interactions of sedentary behaviour with ADRA1A, CHMP1A, COMT, and SCN9A genes were associated with pain-related outcomes. Collectively, findings from the present study indicate a modest contribution of genetics and gene-sedentary behaviour interaction to pain and pain catastrophizing in women with fibromyalgia. Future research should examine whether reducing sedentary behaviour is particularly beneficial for reducing pain in women with genetic susceptibility to pain.

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COMT rs4818, pain sensitivity and duration, and alveolar bone grafting of oral clefts

Cited by 6 publications

References 29 publications

COMT rs4818 less common allele is associated with psychological and psychiatric worse indicators in a cohort of individuals born with cleft lip and palate

COMT rs4818 less common allele is associated with psychological and psychiatric worse indicators in a cohort of individuals born with cleft lip and palate

Pain perception genes, asthma, and oral health: A reverse genetics study

Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project

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