COMT Val108/158Met genotype modulates human sensory gating

Majić, Tomislav; Rentzsch, Johannes; Gudlowski, Yehonala; Ehrlich, Stefan; Juckel, Georg; Sander, Thomas; Lang, Undine E.; Winterer, Georg; Gallinat, Jürgen

doi:10.1016/j.neuroimage.2010.12.031

Cited by 24 publications

(17 citation statements)

References 84 publications

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“…Studies involving healthy controls have also reported weaker P50 gating ability with increased age (Patterson et al, 2008;Turetsky et al, 2008). The mean age of the participants in the three other COMT/sensory gating studies were 43.5, 42.3 and 41.3 (Lu et al, 2007;Majic et al, 2011;Shaikh et al, 2011), reaching as high as 65 years, whereas the mean age in the present study was approximately 22.4 years. Furthermore, none of these studies controlled for smoker (vs. nonsmoker) status as a potential confounding variable, which has also been shown to moderate P50 inhibition (Crawford et al, 2002;Croft et al, 2004).…”

Section: Comparison With Previous Findingscontrasting

confidence: 50%

“…Shaikh et al (2011) found no association between Val158Met and P50 gating in SZ patients, first-degree relatives, and controls. Majic et al (2011) also reported that P50 gating was not affected by COMT genotype in healthy controls. Cao et al (2012) showed that nicotine increased P20 (P50 mouse analog) amplitude and latency in COMT-Val transgenic mice.…”

Section: Introductionmentioning

confidence: 93%

“…The other two studies involving P50 sensory gating and the COMT Val158Met polymorphism found no association in both a large sample consisting of SZ patients (n=138), first-degree relatives (n=109) and healthy subjects (n=204) (Shaikh et al, 2011) and a sample of healthy controls (n=282) (Majic et al, 2011). However, the methodology of these studies varied greatly with regard to the study sample, P50 paradigm and recording, as well as ERP processing.…”

Section: Comparison With Previous Findingsmentioning

confidence: 99%

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Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors

et al. 2013

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Elevated smoking rates seen in schizophrenia populations may be an attempt to correct neuropathologies associated with deficient nicotinic acetylcholine receptors and/or dopaminergic systems using exogenous nicotine. However, nicotine's effects on cognitive processing and sensory gating have been shown to be baseline-dependent. Evidence of a restorative effect on sensory gating deficits by nicotine-like agonists has been demonstrated, however, its underlying mechanisms in the context of dopamine dysregulation are unclear. Catechol-O-methyltransferase (COMT), a key dopamine regulator in the brain, contains a co-dominant allele in which a valineto-methionine substitution causes variations in enzymatic activity leading to reduced synaptic dopamine levels in the Val/Val genotype. Using a randomized, double-blind, placebo-controlled design with 57 non-smokers, this study examined the effects of COMT genotype on sensory gating and its modulation by nicotine in low vs. high suppressors. The results were consistent with the hypothesis that increased dopamine resulting from nicotine stimulation or Met allelic activity would benefit gating in low suppressors and impair gating in high suppressors, and that this gating improvement with nicotine would be more evident in Val carriers who were low suppressors, while the gating impairment would be more evident in Met carriers who were high suppressors. These findings reaffirm the importance of baseline-dependency and suggest a subtle relationship between COMT genotype and baseline-stratified levels of sensory gating, which may help to explain the variability of cognitive abilities in schizophrenia populations.

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Section: Comparison With Previous Findingscontrasting

confidence: 50%

Section: Introductionmentioning

confidence: 93%

Section: Comparison With Previous Findingsmentioning

confidence: 99%

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Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors

et al. 2013

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“…The COMT polymorphisms also affect sensory processing. An EEG experiment showed that high prefrontal efficiency as suggested by the COMT Met/Met genotype is associated with poor sensory gating of auditory stimuli [43].…”

Section: Discussion (A) Distributed Sites and Distinct Networkmentioning

confidence: 99%

Functional brain networks underlying perceptual switching: auditory streaming and verbal transformations

Kashino

Kondo²

2012

Phil. Trans. R. Soc. B

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Recent studies have shown that auditory scene analysis involves distributed neural sites below, in, and beyond the auditory cortex (AC). However, it remains unclear what role each site plays and how they interact in the formation and selection of auditory percepts. We addressed this issue through perceptual multistability phenomena, namely, spontaneous perceptual switching in auditory streaming (AS) for a sequence of repeated triplet tones, and perceptual changes for a repeated word, known as verbal transformations (VTs). An event-related fMRI analysis revealed brain activity timelocked to perceptual switching in the cerebellum for AS, in frontal areas for VT, and the AC and thalamus for both. The results suggest that motor-based prediction, produced by neural networks outside the auditory system, plays essential roles in the segmentation of acoustic sequences both in AS and VT. The frequency of perceptual switching was determined by a balance between the activation of two sites, which are proposed to be involved in exploring novel perceptual organization and stabilizing current perceptual organization. The effect of the gene polymorphism of catechol- O -methyltransferase (COMT) on individual variations in switching frequency suggests that the balance of exploration and stabilization is modulated by catecholamines such as dopamine and noradrenalin. These mechanisms would support the noteworthy flexibility of auditory scene analysis.

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“…Moreover, associations between sustained attention and variants of a dopamine receptor gene have been observed in ADHD (Bellgrove et al 2005). However, it is well known that an intact dopaminergic neurotransmitter system is not only important for higher cognitive functions, but also for aspects of human perception, such as olfaction (Hsia et al 1999;Cave and Baker 2009), audition (Majic et al 2011;Kashino and Kondo 2012;Li et al 2013), or vision (Müller and Huston 2007). The relevance of dopamine for human perception on the one hand, and the dysfunctional dopaminergic system in ADHD on the other hand, stimulates the assumption of altered perceptual functions in individuals with ADHD.…”

Section: Introductionmentioning

confidence: 99%

Perception in attention deficit hyperactivity disorder

Fuermaier

Hüpen

Vries

et al. 2017

ADHD Atten Def Hyp Disord

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A large body of research demonstrated that individuals with attention deficit hyperactivity disorder (ADHD) suffer from various neuropsychological deficits. In contrast, less is known and only divergent evidence exists on perceptual functions of individuals with ADHD. This is problematic as neuropsychological and perceptual functions are closely interrelated and are often difficult to disentangle in behavioral assessments. This study presents the conduct and results of a systematic literature review on perceptual functions in children and adults with ADHD. This review considers studies using psychophysical methods (objective measurements) and self-and informant reports (subjective measurements). Results indicate that individuals with ADHD have altered perceptual functions in various domains as compared to typically developing individuals. Increased perceptual functions in individuals with ADHD were found with regard to olfactory detection thresholds, whereas reduced perceptual functions were evident for aspects of visual and speech perception. Moreover, individuals with ADHD were found to experience discomfort to sensory stimuli at a lower level than typically developing individuals. Alterations of perceptual functions in individuals with ADHD were shown to be moderated by various factors, such as pharmacological treatment, cognitive functions, and symptom severity. We conclude by giving implications for daily life functioning and clinical practice.

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COMT Val108/158Met genotype modulates human sensory gating

Cited by 24 publications

References 84 publications

Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors

Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors

Functional brain networks underlying perceptual switching: auditory streaming and verbal transformations

Perception in attention deficit hyperactivity disorder

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