Comutagenic effects of valocordin

Дурнев, А. Д.; Даугель-Дауге, Н. О.; Жанатаев, А. К.; Lapitskaya, A. S.; Середенин, С. Б.

doi:10.17816/ecogen10353-58

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…These results are in line with the data on elevation of 8-hydroxy-2'-dioxyguanosine level in biopsy specimens from the gastric antrum in patients with gastritis associated with HP infection [2,11].…”

Section: Resultssupporting

confidence: 89%

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Clustogenesis Level in Children with Gastroduodenal Diseases

et al. 2010

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Section: Resultssupporting

confidence: 89%

“…For example, standard protocols for eradication of Helicobacter pylori (HP) include metronidazole, a potentially clustogenic drug [3,9]. Presumably, activities of potential mutagens in combined therapy with several drugs can be appreciably modifi ed, potentiated (comutagenesis) or reduced (antimutage nesis) [2,4].…”

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confidence: 99%

Clustogenesis Level in Children with Gastroduodenal Diseases

et al. 2010

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Variability of Toxic Action of Carbon Tetrachloride in Rats of Different Ages

Skupnevskiy¹,

Batagova²,

Pukhaeva³

et al. 2019

Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)

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Age-specific changes define the difference in thresholds of sensitivity to the effect of poison and drug substances. The disclosure of features of mechanisms forming the basis of an observed phenomenon will allow increasing the efficiency of health risks management under the negative influence of chemical factors. The purpose of the study was to identify the hepatotoxic action of carbon tetrachloride in rats of different ages. The Wistar rats of two different age groups -3 and 18 months divided into experiment and control were the objects of the study. The methods of study included clinicodiagnostic analysis of key biochemical indicators: bilirubin, cholesterol, alkaline phosphatase (ALP), ALAT, ASAT, hydroperoxides and malondialdehyde. The obtained results illustrate more expressed toxic xenobiotic impact on the organism of older rats. It was shown by relative (experiment/control) increase of hepatospecific enzymes activity in plasma: ALPyoung = 1.5 times, ALPelderly = 2.4 times, ALATyoung = 5.9 times, ALATelderly = 10.5; ASATyoung 3.5, ASATelderly = 4.9 (the different in other parameters was not so obvious). The regularities revealed during the study contradict literary data on age decrease of activity of human and animal cytochromes ensuring metabolic activation of chemicals, including carbon tetrachloride. Thus, the strengthening of toxic impact of carbon tetrachloride on older animals may be caused by weak hepatic blood flow, reduced oxygenation of tissues and hence, longer contact of hepatocytes with high-reactive metabolites. Keywordsage changes, mechanisms of hepatotoxic action, acute toxic hepatitis.I.

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Relevant Aspects of Drug Genetic Toxicology

Дурнев

Жанатаев

2022

Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo pr

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Genotoxic lesions are not only a cause of genetic pathologies and cancer, but also the most common and significant factor of the etiopathology of cardiovascular and neurodegenerative disorders, reproductive losses, infertility, and aging. This requires careful monitoring of the use of potential genotoxicants including medicinal products (MPs), which are a group of compounds intentionally and routinely used by humans. Genotoxicity assesment is highly essential in preclinical drug safety studies. The aim of the study was to analyse the current situation and reveal possible ways of addressing methodological and regulatory issues in genotoxicology to enable proper conduction of drug safety preclinical studies. The article summarises basic concepts of the modern genetic toxicology development and highlights the history of research aimed at identifying mutagenic, clastogenic, and aneugenic effects. The authors analyse regulatory aspects of genotoxicological studies of MPs and consider issues of improving the strategy for genotoxicity testing. The paper gives information about the genotoxicity tests approved for MPs, recommendations for interchangeability of tests in relation to particular study characteristics. The authors carried out a comparative analysis of the tests’ pros and cons with an emphasis that the study of each MP is a separate scientific task. They discuss interpretation of results and prediction of MP carcinogenic potential in genotoxicological studies. Recommendations are given for the optimisation of the MP genotoxicity assessment strategy, considering its partial integration into general toxicity studies. The article stresses the urgent need to develop registration methods for genotoxic events in germ cells, assesses the prospects of new tests, and reviews new trends in drug genotoxicology fundamental research.

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Comutagenic effects of valocordin

Cited by 3 publications

References 8 publications

Clustogenesis Level in Children with Gastroduodenal Diseases

Clustogenesis Level in Children with Gastroduodenal Diseases

Variability of Toxic Action of Carbon Tetrachloride in Rats of Different Ages

Relevant Aspects of Drug Genetic Toxicology

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