Concealed Wolff–Parkinson–White Syndrome revealed by acute coronary syndrome

Abstract

Wolff–Parkinson–White (WPW) syndrome is a conduction disturbance in which atrial impulses are transmitted to the ventricles by an accessory pathway instead of the normal atrioventricular conduction. The WPW syndrome may either simulate myocardial infarction or mask the electrocardiographic abnormalities of an acute MI. However, concealed WPW revealed after an acute coronary syndrome is rare with few cases reported in the literature. This article reports a case of coronary artery disease with ST‐segment elevation in a 57‐year‐old man, previously asymptomatic, with an initial electrocardiogram showing no conduction abnormalities that subsequently presented with an ECG compatible with WPW.

Prenatal overgrowth and polydramnios: Would you think about Noonan syndrome?

“…This pathway leads to a ventricular pre‐excitation, causing palpitations, syncope, ventricular fibrillation, and even sudden cardiac death. 11 , 12 …”

“…WPW syndrome is characterized by the presence of an accessory atrioventricular pathway, which bypasses the normal atrioventricular conduction. This pathway leads to a ventricular pre‐excitation, causing palpitations, syncope, ventricular fibrillation, and even sudden cardiac death 11,12 …”

“…This pathway leads to a ventricular pre-excitation, causing palpitations, syncope, ventricular fibrillation, and even sudden cardiac death. 11,12 Recently, variants in the PI3K-AKT pathway have been described to be associated with overgrowth syndromes (PIK3CA-Related Overgrowth Spectrum, PROS), such as Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP, MIM # 602501) and Megalencephalypolymicrogyria-polydactyly-hydrocephalus syndrome-1 (MPPH, # MIM but also Congenital lipomatous asymmetric overgrowth, epidermal naevi, skeletal and spinal anomalies syndrome (CLOVES, # MIM 612918), as well as hemimegalencephaly and isolated macrodactyly. 13 For this reason, the analysis of a panel of genes involved in the PI3K/AKT/mTOR pathway was performed from a saliva sample of our patient and the gene panel testing came back negative.…”

Prenatal overgrowth and polydramnios: would you think about Noonan syndrome?

“…This pathway leads to a ventricular pre-excitation, causing palpitations, syncope, ventricular fibrillation and even sudden cardiac death. 11,12 Recently, variants in the PI3K-AKT pathway have been described to be associated with overgrowth syndromes (PIK3CA-Related Overgrowth Spectrum, PROS), such as Megalencephaly-capillary malformationpolymicrogyria syndrome (MCAP, MIM # 602501) and Megalencephaly-polymicrogyria-polydactylyhydrocephalus syndrome-1 (MPPH, # MIM 603387), but also Congenital lipomatous asymmetric overgrowth, epidermal naevi, skeletal and spinal anomalies syndrome (CLOVES, # MIM 612918), as well as hemimegalencephaly and isolated macrodactyly. 13 For this reason, the analysis of a panel of genes involved in the PI3K/AKT/mTOR pathway was performed from a saliva sample of our patient and the gene panel testing came back negative.…”

Volfo-Parkinsono-Vaito Sindromas Ir Fenomenas

“…VPV sindromas -įgimta širdies laidžiosios sistemos patologija, kuri lemia skilvelių preeksitaciją (skilvelių priešlaikinį sujaudinimą), komplikuotą širdies ritmo sutrikimais. VPV fenomenas -EKG metu nustatomi klinikinių simptomų nesukeliantys skilvelių preeksitacijos požymiai [2]. Nepriklausomai nuo klinikinių simptomų pasireiškimo, jauniems pacientams gali išsivystyti gyvybei pavojingos būklės (prieširdžių virpėjimas, pereinantis į skilvelių virpėjimą, staigi mirtis) [3].…”