Concentraciones séricas de selenio en recién nacidos

Gimenez, Fernanda; Beriain, R.M.a Pérez; Moisés, Víctor Rebage; Comet, Ángel García de Jalón; López, José Luis Olivares; Vázquez, Antonio Baldellou

doi:10.1016/s1695-4033(03)78739-6

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Therefore, it remains unclear whether Se concentrations at birth or soon after birth are associated with respiratory outcomes. Although Giménez et al reported that LBWIs had lower serum Se concentrations [11], their study was published in Spanish, which limited dissemination of their results. Nevertheless, their study revealed a possible relationship between Se and birth weight in neonates.…”

Section: Discussionmentioning

confidence: 91%

Associations of Maternal and Neonatal Serum Trace Element Concentrations with Neonatal Birth Weight

et al. 2013

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BackgroundTrace elements play important nutritional roles in neonates. Our objective was to examine whether there are differences in maternal/neonatal serum trace element concentrations between mature infants and premature infants.MethodsDuring 2012, 44 infants born at National Center for Global Health and Medicine, Tokyo, Japan, were enrolled. Serum samples were collected to measure serum iron, zinc, copper, and selenium concentrations 5 days after birth. Maternal serum samples were obtained before delivery and cord blood was taken at delivery to measure the same trace elements. We compared the results between term group whose birth weight were ≥2500 g and gestational age were ≥37 weeks and premature group whose birth weight were <2500 g or gestational age were <37 weeks. Variables significantly different between two groups were included in linear regression models to identify significant predictors of birth weight. Values of P<0.05 were considered statistically significant.ResultsSerum selenium concentrations were lower in premature group than in term group (43.3±7.0 µg/L vs. 52.0±8.9 µg/L, P = 0.001). Maternal serum selenium concentrations were also significantly lower in the mothers of premature group than in the mothers of term group (79.3±19.3 µg/L vs. 94.1±18.1 µg/L, P = 0.032). There were no significant differences in neonatal or maternal iron, zinc, or copper concentrations between two groups. Multivariate linear regression analysis showed that, except for gestational age, only maternal serum selenium was significantly associated with birth weight (P = 0.015).ConclusionsSerum selenium concentrations were lower in premature group and their mothers compared with the term group. The maternal serum selenium concentration was positively correlated with birth weight. These results suggest that maternal serum selenium concentration may influence neonatal birth weight.

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Section: Discussionmentioning

confidence: 91%

Associations of Maternal and Neonatal Serum Trace Element Concentrations with Neonatal Birth Weight

et al. 2013

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“…It is also widely acknowledged that PIH influences fetal development. There are some studies evaluating selenium levels in neonates, and mostly in preterm, in close relation to maternal selenium levels as a basis for optimization of selenium supplementation ( 20 , 27 – 30 ). However, little is known about selenium levels in term neonates in concomitant relation to maternal PIH, gestational age, and birthweight.…”

Section: Introductionmentioning

confidence: 99%

Selenium status in term neonates, according to birth weight and gestational age, in relation to maternal hypertensive pathology

et al. 2023

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BackgroundPregnancy represents a state of increased oxidative stress and antioxidants, in which selenium (Se) plays a pivotal role, contribute to maintain the oxidative balance. If antioxidant defenses are depleted, placental function is disrupted, resulting in pregnancy complications, including pregnancy-induced hypertension (PIH). Little is known about fetal selenium status in concomitant relation to maternal PIH, gestational age (GA) and birthweight (BW).MethodsWe examined over a 3-year period the serum (SeS) and urine selenium (SeU) status in term neonates from normotensive (nonPIH) and hypertensive (PIH) mothers as clinical markers of oxidative stress. In this retrospective observational study, 72 neonates with maternal PIH were matched for GA and BW to 72 neonates of normotensive mothers. Four groups were obtained, based on maternal PIH and BW relative to GA (appropriate-for-gestational-age—AGA, small-for-gestational-age—SGA): nonPIH-AGA (control group), nonPIH-SGA, PIH-AGA, and PIH-SGA.ResultsThe results showed significant differences (p < 0.001) in selenium levels among the study groups: SeS - 44.85 ± 7.56 μg/L in nonPIH-AGA, 39.62 ± 11.42 μg/L in nonPIH-SGA, 40.01 ± 10.07 μg/L in PIH-AGA, and 25.39 ± 8.99 μg/L in PIH-SGA; SeU - 27.98 ± 7.99 μg/L in nonPIH-AGA, 22.85 ± 9.48 μg/L in nonPIH-SGA, 23.44 ± 6.73 μg/L in PIH-AGA, and 13.05 ± 5.86 μg/L in PIH-SGA. Selenium depletion was more common in neonates born from hypertensive mothers and those born small for gestational age. Though moderate in intensity, selenium levels were positively correlated with BW (0.319 for SeS, 0.397 for SeU) and negatively correlated with maternal systolic blood pressure (−0.313 for SeS, −0.324 for SeU). The main independent effects on SeS and SeU of each maternal blood pressure and birth weight turned out statistically significant. In interaction, a more pronounced effect was reached in PIH-SGA neonates.ConclusionSelenium status seemed to reflect the negative impact that PIH exerts in neonates during intrauterine development. Clinical markers of selenium status could thus be of great value for tracking responses of individuals to selenium supplementation as part of health improvement and harm mitigation approaches.

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Medición del contenido de selenio en especímenes biológicos: aplicación en el laboratorio clínico

Ruiz¹,

Bru²,

Ballesteros

et al. 2019

Revista del Laboratorio Clínico

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Concentraciones séricas de selenio en recién nacidos

Cited by 3 publications

References 21 publications

Associations of Maternal and Neonatal Serum Trace Element Concentrations with Neonatal Birth Weight

Associations of Maternal and Neonatal Serum Trace Element Concentrations with Neonatal Birth Weight

Selenium status in term neonates, according to birth weight and gestational age, in relation to maternal hypertensive pathology

Medición del contenido de selenio en especímenes biológicos: aplicación en el laboratorio clínico

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