Concentrated Growth Factors (CGF) Combined with Melatonin in Guided Bone Regeneration (GBR): A Case Report

Leonida, A; Favero, Gaia; Caccianiga, Paolo; Ceraulo, Saverio; Rodella, Luigi Fabrizio; Caccianiga, Gianluigi

doi:10.3390/diagnostics12051257

Cited by 8 publications

(7 citation statements)

References 40 publications

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“…in a clinical case showed combined use of concentrated growth factors and melatonin in guided bone regeneration treatment of bony defect may have essential roles in healing bone defect, improving implant osteointegration and preventing postoperative complications. [ 40 ] According to Gonde et al . the use of 1% melatonin gel as an adjunct to nonsurgical periodontal therapy in treatment of intrabony defect in Stage III periodontitis is more beneficial in achieving better clinical and radiographic outcome at 6 months, which are consistent with our study.…”

Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of the effect of melatonin gel on bone regeneration in rat model

Golpasandhagh,

Samie,

Sabiza

et al. 2023

Journal of Indian Society of Periodontology

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Background: The purpose of this research was to investigate the effects of different doses of topical melatonin gel on bone regeneration in rat calvarial defects using histological analysis. Materials and Methods: Fifteen adult female Wistar rats weighing approximately 200 g were used and 8 mm in diameter defects were created in their calvaria. The rats were divided into three groups: 1.2% melatonin gel, 5% melatonin gel, and the control group. The animals were sacrificed after 4 weeks. Hematoxylin and eosin staining were used to prepare histological sections. Statistical analysis was performed using the Analysis of variance and Tukey’s post-hoc test. P < 0.05 was considered significant. Results: The results showed a significant difference in rate of ossification (P < 0.001), area of new capillaries (P = 0.002), and mean degree of inflammation (P < 0.001) between the three groups. Comparing groups pairwise, degree of inflammation (P = 0.003) and area of new capillaries (P = 0.019) were significantly lower in the 5% melatonin gel group than the 1.2% melatonin gel group (P = 0.003). The percentage of ossification was substantially greater in the 5% melatonin gel group than in the control and 1.2% melatonin gel groups (P < 0.001). Conclusion: Within the limitations of this animal study, our findings revealed that melatonin gel can be used as a stimulant of bone formation. Outcomes in this study show increased percentage of ossification in the melatonin groups when compared with the control, in a dose-dependent manner, as 5% melatonin gel has a greater effect on ossification.

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Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of the effect of melatonin gel on bone regeneration in rat model

Golpasandhagh,

Samie,

Sabiza

et al. 2023

Journal of Indian Society of Periodontology

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“…Melatonin’s (ML) involvement in hard tissues has gotten a lot of attention [ 163 , 164 ]. The indoleamine ML (N-acetyl-5-metoxy-tryptamine) is produced and released by the pineal gland in a circadian rhythm [ 165 ].…”

Section: Examples Of Repositioned Hormones For Bone and Periodontal T...mentioning

confidence: 99%

Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review

et al. 2022

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Bone and periodontium are tissues that have a unique capacity to repair from harm. However, replacing or regrowing missing tissues is not always effective, and it becomes more difficult as the defect grows larger. Because of aging and the increased prevalence of debilitating disorders such as diabetes, there is a considerable increase in demand for orthopedic and periodontal surgical operations, and successful techniques for tissue regeneration are still required. Even with significant limitations, such as quantity and the need for a donor area, autogenous bone grafts remain the best solution. Topical administration methods integrate osteoconductive biomaterial and osteoinductive chemicals as hormones as alternative options. This is a promising method for removing the need for autogenous bone transplantation. Furthermore, despite enormous investigation, there is currently no single approach that can reproduce all the physiologic activities of autogenous bone transplants. The localized bioengineering technique uses biomaterials to administer different hormones to capitalize on the host’s regeneration capacity and capability, as well as resemble intrinsic therapy. The current study adds to the comprehension of the principle of hormone redirection and its local administration in both bone and periodontal tissue engineering.

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“…Osseous regeneration, the process of growing new bone tissue to fill in areas of bone loss, relies on the migration of osteogenic cells to the defect region (Figure c). , This can be achieved through the use of various techniques and materials including the usage of growth factors . Growth factors are substances that promote the growth and differentiation of cells such as bone cells.…”

Section: Introductionmentioning

confidence: 99%

“… 8 , 9 This can be achieved through the use of various techniques and materials including the usage of growth factors. 10 Growth factors are substances that promote the growth and differentiation of cells such as bone cells. They can be derived from various sources, including human or animal tissue, or artificially created.…”

Section: Introductionmentioning

confidence: 99%

Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations

et al. 2023

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Lack of horizontal and vertical bone at the site of an implant can lead to significant clinical problems that need to be addressed before implant treatment can take place. Guided bone regeneration (GBR) is a commonly used surgical procedure that employs a barrier membrane to encourage the growth of new bone tissue in areas where bone has been lost due to injury or disease. It is a promising approach to achieve desired repair in bone tissue and is widely accepted and used in approximately 40% of patients with bone defects. In this Review, we provide a comprehensive examination of recent advances in resorbable membranes for GBR including natural materials such as chitosan, collagen, silk fibroin, along with synthetic materials such as polyglycolic acid (PGA), polycaprolactone (PCL), polyethylene glycol (PEG), and their copolymers. In addition, the properties of these materials including foreign body reaction, mechanical stability, antibacterial property, and growth factor delivery performance will be compared and discussed. Finally, future directions for resorbable membrane development and potential clinical applications will be highlighted.

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Concentrated Growth Factors (CGF) Combined with Melatonin in Guided Bone Regeneration (GBR): A Case Report

Cited by 8 publications

References 40 publications

Histopathological evaluation of the effect of melatonin gel on bone regeneration in rat model

Histopathological evaluation of the effect of melatonin gel on bone regeneration in rat model

Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review

Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations

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