Concentration characteristics of bovine β‐defensin 1 and 2 in fresh bovine milk and infant formula

Wang, Xiaofang; Cao, Rui-Ming; Li, Jing; Wu, Shaofeng; Chen, Tongxin

doi:10.1111/1471-0307.12214

Cited by 3 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Veldhuizen et al [ 21 ] shown that infection with Salmonella typhimurium did not alter the expression of β-defensin-1 and β-defensin-2 in the intestines of pigs. Wang et al [ 22 ] found that the concentration of BNBD-1 in colostrum on the day following calving was higher than on the 5th day.…”

Section: Resultsmentioning

confidence: 99%

Investigation of serum beta-defensin-1 level in calves with coccidiosis

Koçhan

2021

J Adv Vet Anim Res

View full text Add to dashboard Cite

Objective: Coccidiosis is a protozoan infection that can result in hemorrhagic diarrhea, depression, weakness, weight loss, and even mortality in young animals. β-defensin-1 is an antimicrobial peptide produced largely by epithelial cells in the skin and mucosa. It possesses antifungal, antibacterial, antiparasitic, and antiviral properties. The goal of this study was to evaluate how β-defensin-1 levels changed in coccidiosis-infected calves. Materials and Methods: The sample included 10 coccidiosis-positive calves and 7 healthy calves, for a total of 17 calves of diverse breeds and older than 15 days. To assess the level of β-defensin-1, blood samples were obtained from the vena jugularis of the animals. The concentrations of β-defensin-1 in the serum were measured using a commercial ELISA kit. Results: Although the serum β-defensin-1 level decreased in infected animals, the drop was not statistically significant when compared to the control group. Conclusion: According to the study’s findings, there was no significant change in the serum β-defensin-1 level in coccidiosis-infected calves. We believe that it will be advantageous to conduct additional studies with a larger sample size in order to acquire more precise results.

show abstract

Section: Resultsmentioning

confidence: 99%

Investigation of serum beta-defensin-1 level in calves with coccidiosis

Koçhan

2021

J Adv Vet Anim Res

View full text Add to dashboard Cite

show abstract

“…Veldhuizen et al [32] reported that the intestinal expression of β-defensin-1 and β-defensin-2 did not alter in pigs infected with Salmonella Typhimurium. Wang et al [19] determined high levels of BNBD-1 and BNBD-2 in fresh bovine colostrum, with 0.45-9.36 µg/mL and 45.97-458.82 µg/mL, respectively, on postpartum day 2 and 0.49-7.19 µg/mL and 37.06-465.90 µg/mL, respectively, on postpartum day 5. Van Damme et al [21] indicated that the gene expression of β-defensin-1 was high in dogs with atopic dermatitis.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to their antimicrobial effects, beta-defensins (β-defensins) are reported to mediate angiogenesis and play a role in epithelial growth and differentiation during wound healing [16]. β-defensins, which are secreted from several tissues in cattle, are also referred to as bovine neutrophil beta-defensins (BNBD) [19]. Studies have reported that following the development of skin infection, the level of antimicrobial peptides found in the skin increases because of neutrophil degranulation [20], and the production of β-defensin plays an important role in skin defense [21].…”

Section: Introductionmentioning

confidence: 99%

Investigation of serum beta-defensin-1 levels in bovine trichophytosis cases

Şimşek

2021

Vet World

View full text Add to dashboard Cite

Background and Aim: Antimicrobial peptides are polypeptides that are a component of innate immunity and exhibit antifungal activity. This study aimed to investigate serum beta-defensin-1 levels in cattle diagnosed with trichophytosis, which is a zoonotic skin disease that affects several animal species. Materials and Methods: A total of 23 young cattle, aged 2-4 months, of different breeds and sexes were selected. Of these, 16 cattle were clinically diagnosed with trichophytosis and seven were healthy. Results: The mean serum beta-defensin-1 levels of the infected animals were lower than those of control animals, yet the difference between the two groups was not significant (p>0.05). Conclusion: No significant alterations occurred in serum beta-defensin-1 levels of cattle with trichophytosis.

show abstract