Concentration‐dependent effect of (−) epicatechin in hypertensive patients

Kumar, Navneet; Kant, Ruchi; Maurya, Pawan Kumar

doi:10.1002/ptr.3119

Cited by 21 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, only few clinical studies have reported effects of green tea supplementation in antioxidant markers. Existing clinical data show increased glutathione activity following ex vivo treatment of erythrocytes with green tea polyphenols [18], or dietary supplementation of polyphenol-mixture containing green tea [19]. Recently, total antioxidant status (TAS) was shown to be significantly increased in obese patients with insulin resistance and hypertension, following green tea extracts supplementation, but the study did not measure any enzymatic or non-enzymatic antioxidants [31].…”

Section: Discussionmentioning

confidence: 99%

“…Green tea has also been shown to up-regulate the activities of endogenous antioxidant enzymes, such as catalase, superoxide dismutase and/or glutathione antioxidant enzyme systems in animal models of chemical-induced oxidative stress [11, 16–17]. Limited clinical trials provide evidence on the effects of green tea, either alone or in combination with other polyphenols, in increasing glutathione levels in patients with hypertension and type 2 diabetes [18–19]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome

et al. 2013

View full text Add to dashboard Cite

Green tea, a popular polyphenol-containing beverage, has been shown to alleviate clinical features of the metabolic syndrome. However, its effects in endogenous antioxidant biomarkers are not clearly understood. Thus, we tested the hypothesis that green tea supplementation will up-regulate antioxidant parameters (enzymatic and non-enzymatic) in adults with the metabolic syndrome. Thirty-five obese participants with the metabolic syndrome were randomly assigned to receive one of the following for 8 weeks: green tea (4 cups/day), control (4 cups water/day), or green tea extract (2 capsules and 4 cups water/day). Blood samples and dietary information were collected at baseline (0 week) and 8 weeks of the study. Circulating carotenoids (alpha-, beta-carotene, lycopene) and tocopherols (alpha-, gamma-tocopherols), and trace elements were measured using high performance liquid chromatography (HPLC) and inductively-coupled plasma mass spectroscopy (ICP-MS), respectively. Serum antioxidant enzymes (glutathione peroxidase, glutathione, catalase) and plasma antioxidant capacity were measured spectrophotometrically. Green tea beverage and green tea extract significantly increased plasma antioxidant capacity (1.5μmol/L to 2.3μmol/L and 1.2μmol/L to 2.5μmol/L respectively, p<0.05) and whole blood glutathione [1783 μg/g hemoglobin (Hb) to 2395 μg/g Hb and 1905 μg/g Hb to 2751 μg/g Hb, respectively, p<0.05] versus controls at 8 weeks. No effects were noted in serum levels of carotenoids and tocopherols and glutathione peroxidase and catalase activities. Green tea extract significantly reduced plasma iron versus baseline (128μg/dL to 92μg/dL, p<0.02), while copper, zinc, and selenium were not affected. These results support the hypothesis that green tea may provide antioxidant protection in the metabolic syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Recently we reported the role of tea catechins in aging and other age related diseases (Maurya and Prakash, 2011;Kumar et al, 2010). Tea catechins have been shown to protect erythrocytes from oxidative stress induced by tert-butyl hydroperoxide (t-BHP) by decreasing MDA levels and preventing oxidation of membrane -SH groups.…”

Section: Agingmentioning

confidence: 99%

Role of tea catechins in prevention of aging and age-related disorders

Khanna¹,

Maurya²

2012

TANG [HUMANITAS MEDICINE]

Self Cite

View full text Add to dashboard Cite

Tea polyphenols especially catechins have long been studied for their antioxidant and radical scavenging properties. Scientists throughout the world have investigated the usefulness of the regular green tea consumption in several disease conditions. In-vitro and in-vivo experiments on catechins especially epigallocatechingallate have revealed a significant role in many ways. Reactive oxygen species have been increasingly implicated in the pathogenesis of many diseases and important biological processes. Toxic effects of these oxidants, commonly referred to as oxidative stress, can cause cellular damage by oxidizing nucleic acids, proteins, and membrane lipids. Oxidative stress has been related to aging and age related disorders. It is found that in a wide variety of pathological processes, including cancer, atherosclerosis, neurological degeneration, Alzheimer's disease, ageing and autoimmune disorders, oxidative stress has its implications. Catechins have been reported to be useful in combating aging and age related disorders like cancer, cardiovascular disorders and neurodegenerative diseases. In this mini review we will discuss such studies done across the globe.

show abstract

“…Previous studies indicated concentration dependent effects of epicatechin on biomarkers of oxidative stress in hypertensive and normal patients. The mode of action involves reduction of malondi-aldehyde (MDA) and protein carbonyl content with an increase in glutathione (GSH) and membrane sulfhydryl (−SH) content [115]. Recently we also found that epicatechin is a potent inhibitor of E. coli ATP synthase.…”

Section: Inhibitory Effects Of Polyphenolsmentioning

confidence: 99%

Medicinal Chemistry of ATP Synthase: A Potential Drug Target of Dietary Polyphenols and Amphibian Antimicrobial Peptides

Ahmad¹,

Laughlin²

2010

CMC

View full text Add to dashboard Cite

In this review we discuss the inhibitory effects of dietary polyphenols and amphibian antimicrobial/antitumor peptides on ATP synthase. In the beginning general structural features highlighting catalytic and motor functions of ATP synthase will be described. Some details on the presence of ATP synthase on the surface of several animal cell types, where it is associated with multiple cellular processes making it an interesting drug target with respect to dietary polyphenols and amphibian antimicrobial peptides will also be reviewed. ATP synthase is known to have distinct polyphenol and peptide binding sites at the interface of α/β subunits. Molecular interaction of polyphenols and peptides with ATP synthase at their respective binding sites will be discussed. Binding and inhibition of other proteins or enzymes will also be covered so as to understand the therapeutic roles of both types of molecules. Lastly, the effects of polyphenols and peptides on the inhibition of Escherichia coli cell growth through their action on ATP synthase will also be presented.

show abstract

Concentration‐dependent effect of (−) epicatechin in hypertensive patients

Cited by 21 publications

References 23 publications

Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome

Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome

Role of tea catechins in prevention of aging and age-related disorders

Medicinal Chemistry of ATP Synthase: A Potential Drug Target of Dietary Polyphenols and Amphibian Antimicrobial Peptides

Contact Info

Product

Resources

About