Concentration-dependent fabrication of short-peptide-based different self-assembled nanostructures with various morphologies and intracellular delivery property

Abstract

A newly synthesized short peptide PS1 at different concentrations self-assemble into different nanostructures with various morphologies. The spherical units formed at lower concentration, considered as a potential candidate for intracellular delivery.

Constitutionally Isomeric Aromatic Tripeptides: Self‐Assembly and Metal‐Ion‐Modulated Transformations

“…Hence it can be easily controlled by applying different experimental conditions such as solvent, surface, temperature, pH and concentrations, etc . Among the several key parameters that can control the self‐assembling process of the designed monomer unit, concentration plays an important role and directing the aggregation of peptides as a key factor . Das and co‐workers investigated that a protected phenylalanine rich tripeptide self‐assembled into nanospheres at lower concentrations which upon increase in concentration get rearranged and form necklace like assembly by connecting nanospheres and nanotubes …”

“…The presence of aromatic moieties at higher concentrations due to aromatic stacking act as adhesive among the hydrogen bonded cross‐linked arrangement that promotes the formation of nano‐porous sheet like structures. Monomeric building blocks athigher concentrations, realized increased intermolecular nonspecific interactions which also leads to adequate free energy of association …”

Structural Characterization of a New Collagen Biomimetic Octapeptide with Nanoscale Self‐Assembly Potential: Experimental and Theoretical Approaches

“…The pentapeptides EEEEE, RRRRR and FFFFF were purchased from Selleck Chemical LLC (via Diagnostics GmbH, Munchen, Germany). Fmoc-FF-OMe was obtained by liquid phase synthesis strategy and purified according to Sivagnanam et al [56] FAD sodium salt was from Carl Roth (Karlsruhe, Germany) and disodium phosphate was purchased from Merck (Steinheim, Germany).…”

“…The amidated peptide, NH 2 -1 FRSAPFIE 8 -CO-NH 2 , was manually synthesized by solid-phase synthesis (SPPS) and Fmoc/tBu strategy according to the previously reported data. [56] Particularly, a Fmoc Rink amide resin (4-methyl-benzyyidryl-amine type or MBHA; 50-90 mesh, 0.51 mmol g À 1 ) was used as a solid support. The resin was packed and swelled for 30 min in a 5 mL polypropylene reactor equipped with a frit (Carl Roth, Karlsruhe, Germany).…”

Light-induced reversible self-assembly of multi-compartment patchy micelles

“…Self-assembly is an autonomous, high-efficiency method to render complex architectures with the desired functions, especially at the nanoscale. 1 Hierarchical self-assembly has captured the imagination of scientists for decades, given its clear potential to polymer science, 2-4 solution self-assembly, [5][6][7] medical delivery, [8][9][10] etc. As an elegant bottom-up strategy for stepwise crafting of ordered nano-, micro-and macro-scaled super-molecular constructions, 11 hierarchical self-assembly can be directed by solvent selectivity, [12][13][14] electrostatic attraction, 15,16 crystallization, 17 or metal coordination.…”