2010
DOI: 10.1359/jbmr.090802
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Concentration of adipogenic and proinflammatory cytokines in the bone marrow supernatant fluid of osteoporotic women

Abstract: Osteoporosis is characterized by low bone mass, microarchitectural deterioration of bone tissue leading to increased bone fragility, and a resulting susceptibility to fractures. Distinctive environmental bone marrow conditions appear to support the development and maintenance of the unbalance between bone resorption and bone formation; these complex bone marrow circumstances would be reflected in the fluid surrounding bone marrow cells. The content of regulatory molecules in the extracellular fluid from the hu… Show more

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Cited by 73 publications
(57 citation statements)
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References 63 publications
(127 reference statements)
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“…In osteoporotic BM of postmenopausal women, the levels of leptin and adiponectin were significantly lower [107]. Besides, the affinity of leptin receptors on osteoporotic MSCs is also lower [108] indicating decreased leptin signal activity.…”
Section: Excessive Adipose Tissuementioning
confidence: 94%
“…In osteoporotic BM of postmenopausal women, the levels of leptin and adiponectin were significantly lower [107]. Besides, the affinity of leptin receptors on osteoporotic MSCs is also lower [108] indicating decreased leptin signal activity.…”
Section: Excessive Adipose Tissuementioning
confidence: 94%
“…Later, these cells have been proposed to have a role as an energy source, or as modulators of adjacent tissue by the production of paracrine, and autocrine factors (reviewed in Rosen et al, 2009). In fact, adipokines, steroids, and cytokines (Lee et al, 2002;Pino et al, 2010;Rosen et al, 2009;) can exert profound eff ects on neighboring marrow cells, sustaining or suppressing hematopoietic and osteogenic processes (Omatsu et al, 2010;Krings et al, 2012;Rosen et al, 2009;Rodríguez et al, 2008). Thus, the function of bone marrow adipose tissue may be similar to that of extra medullary fat.…”
Section: Relationship Between the Osteo-/ Adipogenesis Pro-cesses -Thmentioning
confidence: 99%
“…Since it may be expected that concentrations measured in the bone marrow fluid (BMF) more reliably refl ect the physiologically relevant levels in the interstitial compartment surrounding the bone cells than values found in blood, we isolated the extracellular bone marrow fl uid by directly spinning bone marrow samples for 20 min at 900xg. Considering the complex organization in such a regulatory milieu, we opted for evaluating some molecules recognized as markers of adipocyte, proinflammatory or osteoclastic/osteoblastic activity (Pino et al, 2010). The concentrations of cytokines or receptors measured in the bone marrow extracellular fluid from control and osteoporotic human donors are indicated in Table II.…”
Section: Studies On the Activity Of Bone Marrow Fluid Of Post-menopaumentioning
confidence: 99%
“…However, the negative correlation between HMW/total-ADIPO ratio and OPG showed in these women indicate that ADIPO could influence bone metabolism by altering osteoblast production of OPG, thereby affecting osteoclasts mediated bone resorption [82]. Other researchers observed an OPG increase in postmenopausal women with osteoporosis and LP, ADIPO as well as RANKL upregulation in postmenopausal women without osteoporosis [83].…”
Section: Prace Oryginalnementioning
confidence: 79%